Product Name: 2-Acetyl-3,5(Or6)-Dimethyl Pyrazine
Chemical Family: Pyrazine derivatives
Synonyms: Raspberry ketone pyrazine, 2-Acetyl-3,6-dimethyl pyrazine
CAS Number: 24544-04-5
EC Number: 246-367-1
Recommended Use: Used as a flavoring agent, ingredient in food, fragrances, and occasionally in scientific research.
Manufacturer/Distributor: Name, address, and emergency contact phone number appear in this section for all suppliers and users.
GHS Classification: Not classified as a hazardous substance under GHS for normal use.
Signal Word: None required under most classification systems.
Hazard Statements: May cause mild irritation to eyes, skin, and respiratory tract in sensitive individuals.
Precautionary Statements: Avoid inhalation, avoid contact with skin and eyes, wash hands after handling.
Potential Health Effects: Prolonged exposure could result in mild respiratory discomfort or minor skin sensitivity; does not typically cause serious health concerns in humans.
Environmental Impact: Large spills can introduce organic load into water or soil, but rapid breakdown reduces long-term risk.
Chemical Identity: 2-Acetyl-3,5(Or6)-Dimethyl Pyrazine
Molecular Formula: C8H10N2O
CAS Number: 24544-04-5
Content: Minimum 98% purity
Impurities: Possible trace-level pyrazine isomers and small amounts of residual solvents depending on synthesis method.
Mixtures: Commercial samples may contain small amounts of related flavor compounds, but product is typically supplied as a single-ingredient material.
Inhalation: Move to fresh air, rest, seek medical attention if symptoms persist.
Skin Contact: Wash thoroughly with mild soap and water, remove contaminated clothing if large area is affected.
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses if present and easy to do, continue rinsing.
Ingestion: Rinse mouth with clean water, seek medical advice if any discomfort develops.
Symptoms of Exposure: Mild irritation, transient coughing, minimal risk from accidental exposure under normal handling.
Flammability: Combustible solid, not highly flammable but will burn if exposed to sufficient heat or flame.
Suitable Extinguishing Media: Foam, dry chemical, CO₂, water spray.
Unsuitable Media: Avoid using a direct water stream for large fires as splattering can occur.
Hazardous Combustion Products: Carbon monoxide, carbon dioxide, nitrogen oxides, traces of pyrazine vapors.
Special Protective Equipment: Firefighters wear self-contained breathing apparatus, full protective clothing against chemical exposure.
Firefighting Instructions: Keep containers cool by spraying with water, move product away if safe to do so, avoid inhaling smoke.
Personal Precautions: Ensure adequate ventilation, avoid breathing dust or vapors, wear gloves and goggles.
Environmental Precautions: Prevent discharge to drains, surface and groundwater, use absorbent materials to contain spill.
Methods for Cleanup: Sweep or vacuum up solid powder carefully, dispose of in approved chemical waste container, wash area with water.
Emergency Procedures: Isolate area, restrict access, ventilate enclosed spaces.
Handling: Avoid contact with eyes, skin, and clothing, minimize dust production, keep container tightly closed.
Storage: Store in a cool, dry, well-ventilated location, away from incompatible substances such as strong acids, bases, and oxidizing agents.
Container Materials: Use only containers compatible with organic flavors; original packaging or HDPE suggested.
Incompatibilities: Do not store with strong oxidizers, avoid sources of ignition, moisture can degrade product quality.
Storage Temperature: Store at room temperature (15–25°C), avoid extreme heat or freezing.
Shelf Life: Stable for several years in proper storage, reduced stability if exposed to air or moisture.
Occupational Exposure Limits: No established limits for this compound, but minimize exposure as best practice.
Engineering Controls: Use local exhaust ventilation if handling large amounts or dust is present.
Personal Protective Equipment: Wear safety goggles, chemical resistant gloves, dust mask or particulate respirator for powder.
Hygiene Measures: Wash hands thoroughly after handling, do not eat, drink, or smoke during use, launder clothing frequently.
Environmental Controls: Prevent large-scale release to environment, maintain containment procedures for liquid or powder.
Appearance: Off-white to pale yellow powder or crystalline solid
Odor: Nutty, roast, slightly sweet pyrazine aroma
Odor Threshold: Low, strong aroma detectable at low concentration
Molecular Weight: 150.18 g/mol
Melting Point: 61–66°C
Boiling Point: 270–273°C (approximate, decomposes)
Solubility: Slightly soluble in water, freely soluble in alcohol and most organic solvents
pH: Data not applicable (non-aqueous solid)
Flash Point: >120°C (closed cup, estimated)
Partition Coefficient (log Kow): Not determined, likely moderate due to aromatic structure
Vapor Pressure: Extremely low at ambient temperature
Density: Approximately 1.1 g/cm³
Chemical Stability: Stable under normal ambient conditions, avoid prolonged exposure to heat and moisture.
Reactive Hazard: Not prone to hazardous polymerization, generally does not react with common materials.
Incompatible Materials: Strong acids, bases, and oxidizers can lead to degradation or combustion.
Decomposition Products: Thermal decomposition releases CO, CO₂, nitrogen oxides, possibly pyrazine fragments.
Conditions to Avoid: Direct sunlight, extreme heat, sources of ignition, contact with moisture.
Acute Toxicity: Estimated low toxicity by oral, dermal, or inhalation routes; typical flavor sample exposure not expected to cause harm.
Chronic Effects: Long-term exposure data limited; not associated with major organ toxicity or carcinogenicity by regulatory agencies.
Irritation: Mild eye or skin irritation possible if exposed repeatedly or in concentrated form.
Sensitization: Not expected to cause allergic skin reactions, but rare cases of sensitivity may occur.
Mutagenicity/Carcinogenicity: No relevant evidence from available studies; not listed as a known carcinogen or mutagen.
Other Information: Safety as a food flavor ingredient supported by regulatory reviews.
Ecotoxicity: Low toxicity to aquatic organisms expected; not considered an environmental threat at small scale.
Persistence/Degradability: Readily biodegradable in soil and water; breakdown occurs through microbial action.
Bioaccumulation: Low potential due to rapid degradation and moderate water solubility.
Mobility in Soil: Likely moderate, will not persist or accumulate significantly in terrestrial environments.
Environmental Fate: Used in small quantities for food flavors, minimal risk when used according to standard practices.
Waste Treatment Methods: Dispose of product through authorized chemical waste channels or municipal landfill approved for non-hazardous organic chemicals.
Container Disposal: Rinse empty containers thoroughly, recycle or dispose in compliance with local regulations.
Avoid Disposal Methods: Do not dump into sewers or open water; product may impact biological treatment processes if released undiluted.
Regulatory Information: Classified as non-hazardous for disposal, no special labeling needed under most hazardous waste rules.
UN Number: Not classified as dangerous goods for transport.
Proper Shipping Name: Flavoring substance, solid, non-hazardous.
Transport Hazard Class: None
Packing Group: None
Environmental Hazards: Not environmentally hazardous for air, sea, or road freight.
Special Precautions: Standard care with containment and labeling to avoid leaks or spillage.
Transport Regulations: Follow company and legal requirements for organic solids in interstate and international commerce.
Labeling Requirements: Not subject to mandatory hazard labeling under GHS or EU CLP for typical usage.
Food Additive Regulation: Approved for use as a flavoring agent under FDA 21 CFR 172.515, FEMA GRAS number 3285.
TSCA Status: Listed in the US Toxic Substances Control Act inventory.
REACH Compliance: Registered under Annex V for food use in Europe.
Other Regulations: Listed in inventories for Canada (DSL), Australia (AICS), and Japan (ENCS); not subject to specific workplace or environmental restrictions under normal handling, but local and customer-specific requirements may apply.
