Product Name: 2,6-Pipecolinoxylidide Hydrochloride
Chemical Formula: C15H24ClN3O
CAS Number: 6108-05-0
Synonyms: 2,6-xylidine, 2,6-dimethylaniline derivative hydrochloride
Use: Local anesthetic in pharmaceutical manufacturing
Manufacturer Contact: Refer to packaging or supplier documentation
Emergency Telephone Number: Refer to local poison control or emergency response provider
GHS Classification: Acute toxicity (oral, dermal, inhalation), skin and eye irritant
Hazard Pictograms: Skull and crossbones, exclamation mark
Signal Word: Danger
Hazard Statements: Toxic if swallowed, inhaled, or in contact with skin; causes skin and eye irritation; may cause respiratory irritation
Precautionary Statements: Avoid all unnecessary exposure, prevent ingestion, inhalation, and skin contact, work under fume hood or in well-ventilated area, use personal protective equipment
Chemical Name: 2,6-Pipecolinoxylidide Hydrochloride
Purity: >98%
Impurities: Minor organic compounds (<1%)
Stabilizers/Additives: None identified
Other Ingredients: None
Molecular Weight: 281.82 g/mol
Inhalation: Move person to fresh air; seek medical attention if symptoms such as coughing, shortness of breath, or dizziness appear
Skin Contact: Remove contaminated clothing; wash skin thoroughly with soap and water for at least 15 minutes; seek medical attention for irritation or allergic reaction
Eye Contact: Flush eyes with large amounts of water for at least 15 minutes, lifting eyelids to remove substance; seek immediate medical attention
Ingestion: Rinse mouth; do not induce vomiting; seek immediate medical attention
Symptoms: Drowsiness, convulsions, numbness, respiratory distress; follow doctor’s instructions for treatment
Suitable Extinguishing Media: Water spray, carbon dioxide, dry chemical powder, foam
Specific Hazards: May emit toxic fumes of nitrogen oxides, hydrochloric acid, carbon monoxide
Protective Equipment for Firefighters: Self-contained breathing apparatus, full protective gear
Firefighting Procedures: Use water spray to cool containers exposed to fire, avoid inhaling fumes, evacuate area if necessary
Unusual Fire and Explosion Hazards: Dust may form explosive mixtures with air; containers may rupture if heated
Personal Precautions: Wear chemical-resistant gloves, eye protection, respirator if dust present, lab coat
Environmental Precautions: Prevent entry to waterways, drains, or soil, inform authorities if significant spill threatens environment
Cleanup Methods: Scoop up solid; use inert absorbent for solutions; clean area with detergent and water; minimize dust formation
Waste Disposal: Place collected material in labeled container for disposal per local regulations
Decontamination: Wash hands after clean-up, ventilate area thoroughly, check for residual contamination
Safe Handling: Avoid contact with eyes, skin, clothing; prevent inhalation of dust; handle in chemical fume hood; use spark-proof tools
Storage Conditions: Store in tightly closed container in dry, cool, well-ventilated place away from incompatible substances such as strong oxidizing agents and acids
Special Storage Requirements: Protect from light and moisture, label storage area as “Toxic Chemical”, restrict access to trained personnel
Incompatible Materials: Strong acids, oxidizers, bases; reactives that could cause hazardous decomposition
Handling Practices: Conduct regular inspections for leaks or damage, maintain material inventory for traceability
Occupational Exposure Limits: No specific OSHA, ACGIH, NIOSH limits; minimize exposure by engineering controls
Engineering Controls: Local exhaust ventilation, fume hood, HEPA filtration if dust is generated
Personal Protective Equipment: Chemically resistant gloves (nitrile or neoprene), splash-proof safety glasses or goggles, lab coat or protective overall, NIOSH approved respirator for particulates
Hygiene Measures: Wash hands and face after handling, do not eat/drink/smoke during work, change contaminated clothing immediately
Environmental Controls: Use secondary containment for storage, monitor air and water discharges for compliance
Appearance: White to off-white crystalline powder
Odor: Faint amine odor
Odor Threshold: Not determined
pH (in water): 4.0–5.0
Melting Point: 165–170°C
Boiling Point: Not determined (decomposes before boiling)
Flash Point: Not applicable (solid)
Flammability: May be combustible at high temperatures
Vapor Pressure: Negligible at room temperature
Solubility: Readily soluble in water, alcohol
Density: 1.10–1.20 g/cm³
Partition Coefficient (n-octanol/water): Not available
Viscosity: Not relevant (solid)
Evaporation Rate: Not applicable
Decomposition Temperature: Above 170°C (may emit toxic vapors)
Chemical Stability: Stable under standard laboratory and storage conditions
Conditions to Avoid: High temperature, moisture, exposure to light
Incompatible Materials: Oxidizing agents, strong acids, strong bases
Hazardous Decomposition Products: May release carbon monoxide, carbon dioxide, nitrogen oxides, hydrochloric acid gas
Polymerization: Not expected to occur
Reactivity Profile: Tends to remain inert with most chemicals if kept dry and cool
Likely Routes of Exposure: Inhalation, ingestion, dermal, eye contact
Acute Toxicity: Harmful if swallowed, inhaled, or absorbed through skin; LD50 (oral, rat): 230–400 mg/kg (select data)
Corrosive/Irritant Effects: Causes eye and skin irritation
Sensitization: Prolonged or repeated contact may cause allergic reactions
Chronic Effects: Prolonged exposure may cause nervous system effects—tremors, drowsiness, convulsions
Carcinogenicity: Not classified as carcinogenic by IARC, OSHA, NTP
Reproductive Toxicity: Not expected based on available data; handle as potentially toxic
Other Effects: Possible methemoglobinemia, cyanosis, hypotension if large quantities absorbed
Medical Conditions Aggravated: Respiratory, liver, kidney, nervous system disorders
Ecotoxicity: Moderately toxic to aquatic organisms; may cause adverse effects in aquatic environments if released
Persistence/Degradability: Not readily biodegradable; may persist in soil and water
Bioaccumulation: Low potential based on structure and solubility
Mobility in Soil: May migrate through soil if spilled; soluble in water
Other Adverse Effects: No known significant effects at low concentrations, but avoid all unnecessary release
Discharge Notes: Prevent entry to sewers, surface water, or groundwater
Disposal Methods: Treat as hazardous chemical waste; use licensed chemical disposal company
Contaminated Packaging: Dispose in accordance with local, regional, national, and international regulations; do not reuse containers
Incineration: Incinerate in chemical incinerator equipped with afterburner and scrubber
Recycling: Not suitable
Precautions for Disposal: Avoid dispersal of dust into air; prevent release to environment
Regulatory Waste Codes: Consult local regulations for applicable waste codes
UN Number: UN 2811
UN Proper Shipping Name: Toxic solid, organic, n.o.s. (2,6-Pipecolinoxylidide Hydrochloride)
Transport Hazard Class: 6.1 (Toxic substances)
Packing Group: III
Marine Pollutant: No
Special Precautions: Keep container tightly closed, store away from incompatible substances during transport, protect from rough handling and physical damage
Transport Labels: Toxic substance, Class 6.1
TSCA Status: Not listed on United States TSCA inventory
EU Regulations: Subject to REACH; handle as toxic chemical per Annex II guidelines
OSHA Hazard Communication: Classified as hazardous per 29 CFR 1910.1200
SARA 311/312 Hazards: Immediate (acute), delayed (chronic) health hazard
California Proposition 65: Not listed
Japan, Canada, Australia Inventory: Not listed
Other Regulatory Notes: Ensure workplace chemical safety plans reference specific local regulations
