Product Name: 2,5(Or6)-Dimethyl Pyrazine
Chemical Formula: C6H8N2
CAS Number: 123-32-0
EC Number: 204-613-6
Use: Flavoring agent, chemical intermediate, laboratory reagent
Supplier Details: Manufacturer and distributor contact details, including address and emergency telephone number, should appear on the product label or safety documentation supplied with the shipment
Synonyms: 2,5-Dimethylpyrazine, 2,6-Dimethylpyrazine
GHS Classification: Eye irritant Category 2A, Skin irritant Category 3
Symbol: Exclamation mark
Signal Word: Warning
Hazard Statements: Causes skin and eye irritation, may cause respiratory tract irritation
Precautionary Statements: Avoid inhalation of vapor, dust, or mist, wear protective gloves, clothing, and eye protection
Potential Health Effects: Short contact may redden or irritate eyes and skin, longer exposures or inhalation may cause headache, mild dizziness, or nausea
Environmental Hazards: Can impact aquatic organisms, avoid release into environment
Chemical Name: 2,5(Or6)-Dimethyl Pyrazine
Formula: C6H8N2
Concentration: ≥ 98% (as pure substance)
Impurities: No significant impurities expected in standard grades for laboratory or industrial use
Other Ingredients: None reported
Eye Contact: Immediately flush eyes with plenty of clean, running water for 15 minutes, holding eyelids open, remove contact lenses; seek medical help if redness or pain persists
Skin Contact: Wash exposed skin areas with soap and water, remove any contaminated clothing, wash before reuse; persistent irritation means you should get medical advice
Inhalation: Move away from exposure to fresh air, keep at rest; if breathing trouble develops seek immediate medical attention
Ingestion: Rinse mouth, never give fluids to a drowsy person, call physician or poison control for advice; do not induce vomiting unless directed
General Advice: Ensure responders use protective equipment
Suitable Extinguishing Media: Dry chemical, carbon dioxide, foam, water spray for larger fires
Unsuitable Media: Direct water jet may spread burning material
Special Hazards: Decomposition releases irritating or toxic smoke including nitrogen oxides, carbon monoxide, carbon dioxide
Special Protective Equipment for Firefighters: Self-contained breathing apparatus and full gear required
Advice for Firefighters: Move containers from fire if safe to do so, use water spray to keep containers cool
Personal Precautions: Evacuate area if released in large quantity, ventilate space, avoid breathing dust or vapor, wear suitable PPE including gloves and goggles
Environmental Precautions: Do not wash into drains, soil, or waterways; contain release with inert absorbent
Methods for Clean-up: Pick up spilled material with absorbent, place in sealed container for disposal, clean area with detergent and water
Other Precautions: Remove sources of ignition, use spark-proof tools for clean-up
Handling: Work in ventilated area, keep container closed, avoid creating dust or breathing vapor, use PPE, wash hands after handling
Storage Conditions: Store in tightly sealed original containers in a cool, dry area; avoid extreme heat, moisture, sunlight, incompatible substances such as strong oxidizers
Incompatible Materials: Strong acids, oxidizing agents
Specific End Use: Use strictly for designated laboratory or industrial applications, do not use for food or personal care unless food grade is certified and permitted
Exposure Limits: No occupational exposure limits established by OSHA, NIOSH, or ACGIH
Engineering Controls: Use fume hood or local exhaust; maintain adequate ventilation
Personal Protective Equipment: Chemical-resistant gloves (such as nitrile), safety glasses with side shields, laboratory coat, use respiratory protection if ventilation inadequate
Hygiene Measures: Do not eat, drink or smoke during use; wash hands thoroughly after handling
Appearance: Colorless to pale yellow liquid or solid
Odor: Distinct, nutty or roasted note
Odor Threshold: Not established
Melting Point/Range: 35–40°C
Boiling Point/Range: 170–175°C
Flash Point: 62°C (closed cup)
Evaporation Rate: Not determined
Flammability: Combustible at elevated temperature
Vapor Pressure: 0.52 mmHg at 25°C
Solubility: Slightly soluble in water, soluble in ethanol and organic solvents
Density: 1.06 g/cm³
pH: Not applicable as pure liquid/solid
Partition Coefficient (log Kow): 0.4–0.7
Viscosity: Not determined
Chemical Stability: Stable under recommended storage conditions
Thermal Decomposition: May produce toxic nitrogen oxides, carbon oxides
Hazardous Reactions: Reacts with strong oxidizing agents producing fire or explosion risk
Conditions to Avoid: Extreme heat, open flames, hot surfaces
Incompatibility: Strong acids, oxidizers
Hazardous Polymerization: Not expected to occur
Acute Toxicity: Oral LD50 (rat): 800 mg/kg
Skin Corrosion/Irritation: Mild skin irritation documented in animal studies
Serious Eye Damage/Irritation: Transient eye irritation possible
Respiratory or Skin Sensitization: Not sensitizing in standard animal tests
STOT – Single Exposure: May cause respiratory tract irritation
STOT – Repeated Exposure: No significant effects in repeated dose animal studies
Carcinogenicity: Not listed by IARC, NTP, OSHA
Germ Cell Mutagenicity: No data available
Reproductive Toxicity: No data available
Ecotoxicity: Harmful to aquatic organisms, fish LC50 (96h): 17–24 mg/L (Pimephales promelas)
Persistence and Degradability: Readily biodegradable under aerobic conditions
Bioaccumulative Potential: Low, log Kow indicates little bioaccumulation risk
Mobility in Soil: Moderate, may leach into groundwater in large spills
Other Adverse Effects: Large releases can affect water quality locally
Disposal Methods: Dispose by incineration or controlled landfill at licensed facility
Container Disposal: Triple rinse empty containers and puncture before disposal; do not reuse for food or drink
Waste Codes: Follow local, regional or national hazardous waste codes where applicable
Precautions: Prevent chemical from reaching surface waters, public sewers, or soil
UN Number: Not regulated per UN recommendations
Transport Hazard Class: Not classified as hazardous for transport by air, road, sea, or rail
Packing Group: Not assigned
Special Precautions: Prevent container rupture by keeping sealed and upright, transport in spill-proof packaging
Labeling Requirements: Apply standard labeling for industrial chemicals
Safety, Health and Environmental Regulations: Not listed as a controlled substance, included on TSCA inventory (US), REACH registered (EU), Canada DSL
Hazard Symbols: Irritant (Xi), in some jurisdictions
Other Information: Review any workplace or country-specific local regulations that apply, including occupational exposure limits and allowed food use status
Restrictions: Only food grade lots approved for food use; all other grades limited to industrial or laboratory use
