Chemical Name: 2-(4-Fluorophenyl)Thiophene
Synonyms: 4-Fluorophenylthiophene, 2-Thiophenyl-4-fluorobenzene
CAS Number: 123456-78-9
Molecular Formula: C10H7FS
Molecular Weight: 178.23 g/mol
Product Use: Organic synthesis, pharmaceutical development, material science research
Manufacturer Information: LabChem Solutions, 123 Research Avenue, Cambridge, MA, 02139
Contact Number: +1 800-555-1234
Email: info@labchemsol.com
GHS Classification: Acute Toxicity (Oral, Dermal), Skin Irritant, Eye Irritant, Environmental Hazard
Hazard Statements: Harmful if swallowed, may cause skin and eye irritation, suspected central nervous system effects, toxic to aquatic life
Pictograms: Exclamation mark, Environment Hazard Symbol
Signal Word: Warning
Precautionary Statements: Keep away from food and drink areas, avoid breathing dust or fume, wear protective gloves and eyewear, avoid release into the environment
Chemical Name: 2-(4-Fluorophenyl)Thiophene
Concentration: ≥98% by weight
Impurities: Possible traces of unreacted thiophene or fluorobenzene derivatives (≤2%)
CAS Number for main component: 123456-78-9
Inhalation: Move person to fresh air immediately, allow rest in a position comfortable for breathing, seek medical attention if symptoms persist such as headache, drowsiness, or cough
Skin Contact: Remove contaminated clothing, rinse skin with soap and plenty of water for several minutes, use cool water to avoid worsening irritation, seek medical advice if redness or discomfort continues
Eye Contact: Rinse cautiously with water for at least twenty minutes, keep eyelids open and move eyes in all directions, remove contact lenses if present and easy to do, consult with ophthalmologist for persistent pain or vision changes
Ingestion: Rinse mouth thoroughly, do not induce vomiting, drink several small glasses of water or milk, seek urgent medical help
Suitable Extinguishing Media: Carbon dioxide, dry chemical powder, alcohol-resistant foam, avoid large streams of water due to risk of chemical runoff
Specific Hazards: Combustion may produce toxic fumes (sulfur oxides, hydrogen fluoride, carbon monoxide, carbon dioxide)
Advice for Fire-Fighters: Wear full protective suit and self-contained breathing apparatus, stay upwind and avoid inhaling vapors, cool exposed containers with water spray
Explosion Data: Dust generation could present explosion hazard, keep operational areas clean and free of dusty deposits
Personal Protection: Restrict access to trained personnel, put on gloves (nitrile or neoprene), chemical splash goggles, disposable coveralls and a particle mask if powder is present
Spill Containment: Remove sources of ignition, ventilate area, avoid dust formation, stop leak if possible without risk, do not allow to enter drains
Clean-up Methods: Scoop up solid material using disposable, non-sparking tools, place in a secure, labeled waste container, wash site of spill with plenty of water and detergent, ventilate and monitor for vapor residues
Disposal: Dispose collected material in accordance with local, state, and federal environmental regulations
Handling: Work under fume hood, prevent dust and vapor formation, avoid prolonged exposure, keep containers tightly closed, use only with adequate ventilation, wash hands and face thoroughly after handling
Storage: Store in a cool, dry, well-ventilated area away from heat and sources of ignition, keep container upright and tightly sealed, segregate from strong oxidizers, acids, and food items, keep away from direct sunlight and incompatible materials
Exposure Limits: No established OSHA, ACGIH, or NIOSH exposure limits, handle as a potentially hazardous substance
Engineering Controls: Use chemical fume hood, mechanical exhaust recommended for closed areas, maintain local ventilation
Personal Protective Equipment (PPE): Splash-resistant goggles, disposable nitrile gloves, lab coat or full chemical resistant coveralls, face mask, and closed-toe shoes
Hygiene Measures: Avoid eating, drinking, or smoking in work area, wash hands thoroughly after handling, remove contaminated clothing immediately
Appearance: Pale yellow to off-white crystalline powder
Odor: Mild aromatic odor, similar to thiophene
Odor Threshold: Not determined
pH: Not applicable (organic solid)
Melting Point: Approx. 55–59°C
Boiling Point: Approx. 275–285°C at normal pressure
Flash Point: Estimated 115°C (closed cup)
Evaporation Rate: Very low, negligible under normal conditions
Flammability (Solid, Gas): Combustible solid
Upper/Lower Flammable Limits: Not established
Vapor Pressure: Very low at 20°C
Vapor Density: Not applicable
Specific Gravity: 1.18–1.22 (25°C)
Solubility: Insoluble in water, soluble in organic solvents such as dichloromethane, acetone, and ethanol
Partition Coefficient (log Pow): Estimated 3.5–4.2
Auto-ignition Temperature: Not determined
Decomposition Temperature: >200°C
Viscosity: Not applicable
Chemical Stability: Stable at ambient temperature and recommended storage conditions
Reactivity: Does not react rapidly under normal use but incompatible with oxidizing agents, strong acids, and strong bases
Hazardous Reactions: Risk of exothermic reaction with oxidizers, thermal decomposition produces hazardous gases (HF, SOx, phenolic compounds)
Conditions to Avoid: Open flames, high heat, static discharge, moisture, direct sunlight
Incompatible Materials: Chlorinating agents, nitric acid, peroxides, alkali metals
Hazardous Decomposition Products: Sulfur dioxide, hydrogen fluoride, carbon monoxide, unidentified organic fragments
Routes of Exposure: Inhalation, ingestion, skin and eye contact
Acute Effects: Swallowing may cause stomach discomfort, possible nausea and vomiting; skin contact may produce redness or slight burning; inhalation of dust could irritate nose and lungs, dizziness or headache possible; splashes to eyes can lead to watering, redness, pain
Chronic Effects: No comprehensive long-term studies but similar compounds suggest risk of liver and nervous system effects with prolonged exposure
Carcinogenicity: No known classification by IARC, NTP, or OSHA
Mutagenicity: Limited data, suspected low risk
Reproductive Toxicity: Insufficient data; not expected at typical laboratory handling levels
LD50 (Oral, Rat): Estimated 800–1300 mg/kg based on data from structurally similar compounds
Symptoms of Overexposure: Throat and eye burning, coughing, drowsiness, skin rash in sensitive individuals
Ecotoxicity: Harmful to aquatic life, persists in the environment, data from analogues suggest bioaccumulation potential in fish and invertebrates
Mobility in Soil: Low water solubility indicates low mobility, may adsorb to soil or sediment particles
Persistence and Degradability: Decomposes slowly in air, higher persistence in water and soil
Bioaccumulation: Possible accumulation in organisms due to lipophilicity (log Pow above 3)
Other Adverse Effects: Not classified as ozone depleting, avoid uncontrolled release to waterways
Disposal Methods: Collect into tightly closed, clearly labeled hazardous waste containers, do not mix with incompatible or unknown substances, send for incineration in approved chemical disposal facility
Packaging Disposal: Rinse glassware and triple-rinse containers, add rinsate to hazardous waste stream, dispose of packaging by licensed waste handler
Special Precautions: Never dispose to sewer, surface water, or general trash; keep out of landfill unless authorized
UN Number: Not regulated under most international transport codes for laboratory quantities, escalate to hazardous materials status for bulk or commercial packaging
Proper Shipping Name: Laboratory chemical, not otherwise specified
Transport Hazard Class: Not assigned
Packing Group: Not applicable (except for bulk shipments)
Environmental Hazards: Not a marine pollutant in small batches; warn carrier if shipping large volumes
Special Precautions: Avoid temperature extremes, protect drums and flasks from physical damage, segregate from incompatible substances
TSCA (US): Substance listed for research and development use
DSL/NDSL (Canada): May require notification, confirm with supplier or regulatory authority
EU REACH: Research and development exemptions may apply, registration waived for intermediate use below one ton per year
OSHA: Handle in line with chemical hygiene standards for laboratory agents
SARA Title III: No reportable quantities for this CAS
California Prop 65: Not listed as of last update
Other Regulations: Local use subject to lab-specific standard operating procedures and risk assessment requirements; lab supervisors set storage and handling guidelines
