Material Safety Data Sheet – 2,3-Dimethyl Pyrazine

1. Identification

Product Name: 2,3-Dimethyl Pyrazine Chemical Formula: C6H8N2 Synonyms: Pyrazine, 2,3-dimethyl-; 2,3-DMP CAS Number: 5910-89-4 Intended Use: Often used in flavorings, fragrance blends, chemical research Manufacturer: Contact details of supplier, including address and emergency telephone number Recommended Restrictions: For professional and laboratory use; not intended for food or drug production

2. Hazard Identification

GHS Classification: Irritant (eye and skin), harmful if swallowed Signal Word: Warning Pictogram: Exclamation mark Hazard Statements: Causes mild to moderate eye irritation; may cause skin discomfort; ingestion may upset digestive tract Precautionary Statements: Wash exposed skin thoroughly after handling; avoid breathing vapors; wear protective gear; if in eyes, rinse with water Potential Health Effects: Short-term inhalation causes throat irritation; prolonged skin contact leads to dryness and possible rash Routes of Exposure: Inhalation, skin or eye contact, ingestion

3. Composition / Information on Ingredients

Chemical Name: 2,3-Dimethyl Pyrazine Concentration: >98% Impurities: Trace organic solvents (less than 1%) Other Ingredients: None reported Molecular Weight: 108.14 g/mol EC Number: 227-747-3

4. First Aid Measures

General Advice: Remove from exposure; seek medical attention if symptoms persist Inhalation: Move affected person to fresh air, loosen restrictive clothing, support breathing as needed Skin Contact: Wash exposed skin with soap and plenty of water, take off contaminated clothing and wash before reuse Eye Contact: Rinse cautiously with water for at least 15 minutes; lift eyelids occasionally to remove any particles Ingestion: Rinse mouth; drink water if conscious; do not induce vomiting; call a doctor or poison control Note for Doctors: Treat symptomatically; note risk of irritation or sensitization

5. Fire-Fighting Measures

Suitable Extinguishing Media: Use water spray, alcohol-resistant foam, carbon dioxide, or dry chemical Unsafe Extinguishing Media: Avoid water jets that might spread substance Specific Hazards: Combustible; emits toxic fumes of nitrogen oxides or carbon oxides under fire conditions Fire-fighting Instructions: Wear a self-contained breathing apparatus, full protective gear, use water spray to cool surfaces Explosion Hazard: Dust-air mixtures can form explosive concentrations Hazardous Combustion Products: Nitrogen oxides, carbon monoxide, carbon dioxide

6. Accidental Release Measures

Personal Precautions: Restrict unnecessary contact; ventilate area; avoid breathing dust or vapors Protective Equipment: Chemical-resistant gloves, goggles, lab coat, dust mask if needed Environmental Precautions: Keep runoff from entering drains, soil, or waterways Cleanup Method: Sweep up carefully; minimize dust generation; collect residue in container for disposal following regulation Decontamination: Wash spill area with water and mild detergent; dispose of water as hazardous waste Reporting: Notify local authorities if significant quantity released outside controlled environment

7. Handling and Storage

Handling: Use in a well-ventilated space; avoid direct contact with skin and eyes; prevent ingestion and inhalation Hygiene Practices: Wash hands and face before meals; avoid eating or drinking near chemical use Storage Conditions: Store in tightly sealed container, away from light and moisture, in a cool, dry location Incompatible Materials: Strong oxidizing agents, acids, or bases may trigger hazardous reactions Special Packaging: Use containers made of compatible materials; keep containers upright

8. Exposure Controls and Personal Protection

Occupational Exposure Limit: No established OSHA or ACGIH limit for this chemical Engineering Controls: Employ local exhaust ventilation; eye wash station and safety shower near work area Personal Protection – Eye: Safety glasses with side shields or chemical goggles Personal Protection – Skin: Chemical-resistant gloves (nitrile or neoprene); lab coat or apron Personal Protection – Respiratory: NIOSH-approved respirator if dust or vapor risk exists Other Precautions: Take off contaminated clothing and wash before reuse; maintain good house-keeping

9. Physical and Chemical Properties

Appearance: Colorless to pale yellow liquid Odor: Roasted, nutty smell; characteristic pyrazine aroma pH: Not applicable (neutral in solution) Melting Point: -2 °C Boiling Point: 171–173 °C Flash Point: 56 °C (closed cup) Density: 1.03 g/cm³ at 25°C Water Solubility: Slightly soluble Vapor Pressure: 0.6 mm Hg at 25°C Partition Coefficient (n-octanol/water): log Kow 0.42 Viscosity: Similar to water; not measured in detail Auto-Ignition Temperature: Not easily ignited below 400 °C Evaporation Rate: Moderate Upper/Lower Flammability Limits: Not available

10. Stability and Reactivity

Chemical Stability: Stable under normal storage and handling Reactivity: Low risk of dangerous reaction with most substances Hazardous Reactions: Contact with strong oxidizers forms heat, possible toxic gases Thermal Decomposition: Gives off nitrogen and carbon oxides if overheated Incompatible Substances: Avoid mixing with peroxides or acids Polymerization: No risk of hazardous polymerization

11. Toxicological Information

Acute Toxicity: Oral LD50 (rat) estimated at >1000 mg/kg; mild toxicity Skin Corrosion/Irritation: May cause redness, dryness, slight irritation Serious Eye Damage/Irritation: Causes watery, irritated eyes; reversible Respiratory Sensitization: Not classified as a respiratory sensitizer Skin Sensitization: Not likely to trigger allergic reactions Chronic Effects: Repeated exposure linked to mild skin effects Carcinogenicity: Not classified as carcinogen by IARC, NTP, or OSHA Mutagenicity: No genotoxicity observed in standard laboratory tests Reproductive Toxicity: No evidence for harm to fertility or fetuses Target Organ Effects: None known beyond transient irritation

12. Ecological Information

Ecotoxicity: Data on fish, algae, and aquatic invertebrates suggest low acute toxicity Persistence / Degradability: Breaks down slowly in natural environments; not persistent under most conditions Bioaccumulative Potential: Not prone to accumulate in food chain; low log Kow Mobility in Soil: Mobile in soil, mildly soluble in water; potential runoff if spilled PBT/vPvB Assessment: Not classified as persistent, bioaccumulative, or toxic Other Adverse Effects: Limited impact expected in standard wastewater treatment

13. Disposal Considerations

Waste Disposal Methods: Collect spilled material in properly labeled, sealed containers; minimize dust generation Disposal Regulation: Follow federal, state, and local rules for organic chemical waste Contaminated Packaging: Dispose of in accordance with local requirements; triple rinse containers Incineration: Preferred method under controlled conditions at licensed facility Prohibited Disposal Methods: Do not discharge into sewers, surface water, or public landfills

14. Transport Information

UN Number: Not regulated for most land, sea, or air transport classes Proper Shipping Name: Chemical, NOS (not otherwise specified) Hazard Class: Non-hazardous for transport under ADR, IMDG, IATA Packing Group: Not classified Special Precautions: Use leak-proof containers, secure package to prevent movement Environmental Hazards: Not a marine pollutant Transport in Bulk: Avoid bulk transport without regulatory permission

15. Regulatory Information

TSCA (USA): Listed DSL/NDSL (Canada): Listed EINECS (EU): 227-747-3 Hazard Category (US): Immediate (Acute) Health Hazard Right-to-Know Listings: Not on California Proposition 65 Labelling Requirements: Comply with GHS and local regulations; display hazard and precaution phrases Other Regulation: Not controlled under major chemical conventions; maintain safe inventory logs