Chemical Name: 2,3-Dimethyl-5-Ethyl Pyrazine
Synonyms: 5-Ethyl-2,3-dimethylpyrazine
CAS Number: 18138-04-0
Recommended Use: Flavoring agent in food, aroma compound
Manufacturer Information: Contact details of supplier and emergency contact number must be on label
Product Code: As supplied by manufacturer
Emergency Phone: As distributed by supplier documentation
GHS Classification: Eye Irritant (Category 2A), Skin Irritant (Category 3)
Label Elements: Signal Word: Warning, Hazard Statement: Causes eye irritation, May cause skin irritation
Pictogram: Exclamation mark symbol for irritant chemicals
Hazards: Can trigger eye and skin discomfort on contact, possible respiratory irritation if mist or vapor is inhaled, not classified as carcinogen or mutagen, not a reproductive toxin
Precautionary Statements: Avoid breathing vapor or direct contact, wash exposed areas thoroughly after handling, use personal protective gear
Chemical: 2,3-Dimethyl-5-Ethyl Pyrazine
CAS No.: 18138-04-0
Concentration: Greater than 98% purity
Impurities: Trace amounts of structurally related pyrazines or manufacturing byproducts
Other Components: No major stabilizers or additives present
Inhalation: Move affected person into fresh air, keep at rest, seek medical attention if symptoms persist, avoid further exposure
Skin Contact: Rinse skin thoroughly with soap and water, remove contaminated clothing, seek medical help if irritation or rash develops
Eye Contact: Immediately flush eyes with large amounts of water for at least 15 minutes, hold eyelids open, seek physician’s care if irritation does not subside
Ingestion: Rinse mouth, do not induce vomiting, drink water, seek medical advice if you feel unwell or symptoms worsen
Flammability: Combustible liquid, avoid flames, sparks, and hot surfaces
Suitable Extinguishing Media: Use water spray, carbon dioxide, regular dry chemical or foam
Unsuitable Extinguishing Media: Strong water jet streams can spread fire
Specific Hazards: Vapors may form explosive mixtures with air, may emit toxic fumes of nitrogen oxides and carbon oxides during combustion
Protective Equipment: Firefighters should wear self-contained breathing apparatus and full protective clothing, keep containers cool with water spray
Personal Precautions: Evacuate area of unprotected persons, avoid breathing vapor, ventilate area, use protective gloves and eye protection
Environmental Precautions: Prevent entry into drains, surface water, soil; contain spillage with suitable absorbent material such as sand or vermiculite
Cleanup Methods: Scoop up with non-sparking tools, gather absorbed material in suitable containers for safe disposal
Decontamination: After cleanup, flush area with water to remove residue, prevent runoff from entering water systems
Handling: Use only in well-ventilated areas, avoid contact with skin, eyes, and clothing, avoid inhaling vapors, wear appropriate PPE, keep away from sources of ignition
Storage: Store in cool, dry, well-ventilated location, keep tightly closed in original container, segregate from incompatible materials (strong acids, oxidizers), avoid excessive temperatures and direct sunlight, ensure all containers are labeled correctly
Exposure Limits: No established occupational exposure limits, general dust and vapor TWA recommended
Engineering Controls: Provide exhaust ventilation or other engineering controls to keep airborne levels below recommended exposure limits
Personal Protective Equipment: Wear gloves made of nitrile or neoprene, chemical splash goggles, laboratory coat or apron, use NIOSH approved respirator for vapor or mist if exposure limits exceeded
Hygiene Measures: Wash thoroughly after handling, no eating, drinking, or smoking during use, change contaminated clothing before reuse
Appearance: Clear, pale yellow to amber liquid
Odor: Intense nutty, roasted aroma typical of pyrazine derivatives
Odor Threshold: Very low, detectable at trace concentrations
pH: Not applicable, non-aqueous liquid
Melting Point: Below room temperature, approximately -15°C
Boiling Point: 155-170°C (estimate, data limited)
Flash Point: 55-70°C (open cup)
Evaporation Rate: Moderate, similar to other pyrazines
Flammability: Combustible liquid, can form flammable vapor-air mixtures
Vapor Pressure: Low to moderate at room temperature
Vapor Density: Heavier than air
Solubility: Low in water, high in most organic solvents such as ethanol and diethyl ether
Partition Coefficient: Log Kow expected above 2
Auto-ignition Temperature: Data not available
Decomposition Temperature: Above 200°C
Chemical Stability: Stable under recommended storage conditions, sensitive to strong oxidizing agents
Reactivity: May react with strong acids or oxidants, incompatible with strong bases
Hazardous Reactions: No hazardous polymerization expected
Decomposition Products: Can generate carbon monoxide, carbon dioxide, nitrogen oxides when burned or decomposed at high temperatures
Conditions to Avoid: Flames, hot surfaces, direct sunlight, excess moisture
Acute Toxicity: LD50 (oral, rat): greater than 2000 mg/kg, low acute oral toxicity
Skin corrosion/irritation: Mild to moderate irritation possible on prolonged contact
Serious eye damage/irritation: Causes temporary discomfort, redness, tearing
Respiratory or skin sensitization: Not classified as a sensitizer, but repeat exposure may result in irritation
Germ cell mutagenicity: No data to indicate genetic damage in test systems
Carcinogenicity: Not listed as carcinogen by IARC, NTP, or OSHA
Reproductive Toxicity: No evidence in animal studies
Target Organ Effects: May cause central nervous system effects with overexposure to vapor (headache, dizziness)
Ecotoxicity: Expected to be moderately toxic to aquatic life based on structural similarity to other pyrazines
Persistence and Degradability: Not readily biodegradable, may persist in the environment for extended period
Bioaccumulation Potential: Potential for bioaccumulation in aquatic organisms cannot be ruled out
Mobility in Soil: Low due to limited water solubility
Other Adverse Effects: No known significant effects or critical hazards for greenhouse gas emissions or ozone depletion
Waste Disposal Methods: Collect waste in tightly sealed, clearly labeled containers, dispose of through a licensed chemical waste disposal contractor
Contaminated Packaging: Empty containers must be triple rinsed and disposed of as hazardous chemical waste
Precautions: Never dispose of by pouring into drains or natural water sources, avoid release to the environment
UN Number: Not assigned for this compound
UN Proper Shipping Name: Not regulated under ADR/RID, IMDG, or IATA for small quantities
Transport Hazard Class: Not classified as hazardous for transport, though large volume shipments may require combustible liquid declaration
Packing Group: Not applicable
Environmental Hazards: Not marine pollutant as defined by IMO
Special Precautions for User: Keep containers upright and secure during transport, segregate from food and animal feeds
U.S. Regulations: Not included in TSCA inventory as hazardous, not subject to SARA reporting thresholds
EU Regulations: Complies with REACH as a notified flavor ingredient, not classified as a dangerous substance under CLP regulations
Canada: Listed on DSL/NDSL as flavoring agent
Labeling Requirements: Workplace labeling with chemical name, warning statement, and emergency contact recommended
Other Regulatory Listings: Not flagged by California Proposition 65, not on major lists for air or water contaminant control
