Product Name: 2,3,5,6-Tetramethyl Pyrazine
Chemical Formula: C8H12N2
Molecular Weight: 136.19 g/mol
CAS Number: 1124-11-4
Synonyms: Tetramethylpyrazine, TMP
Recommended Use: Flavoring agent in food, chemical intermediate, laboratory research.
Supplier Details: Manufacturer and supplier contact information appears on original packaging, typically including emergency telephone number for immediate inquiries.
GHS Classification: Eye irritation (Category 2A), Skin irritation (Category 2), Specific target organ toxicity (single exposure, Category 3)
Label Elements: Signal word "Warning", pictogram for exclamation mark
Hazard Statements: May cause skin irritation, eye irritation, and respiratory discomfort
Precautionary Statements: Avoid breathing dust, ensure proper ventilation, wear appropriate gloves and eye protection, wash skin thoroughly after handling
Other Risks: At elevated concentrations, vapors or dust may irritate mucous membranes.
Chemical Name: 2,3,5,6-Tetramethyl Pyrazine
Chemical Formula: C8H12N2
Concentration: Typically >99% pure
Impurities: Trace impurities according to supplier’s certificate of analysis, often negligible
Additives: Product supplied without stabilizers or solvents.
Inhalation: Remove affected individual to fresh air, support breathing as needed, seek medical attention for any delayed symptoms
Skin Contact: Wash area with soap and water, remove contaminated clothing, consult physician if irritation continues
Eye Contact: Rinse carefully with water for at least 15 minutes, keep eyelids open, remove contact lenses, seek medical advice if redness or pain persists
Ingestion: Rinse mouth with water, avoid inducing vomiting, call for medical support if feeling unwell
Note to Physician: No known specific antidote, provide symptomatic and supportive care.
Suitable Extinguishing Media: Use water spray, carbon dioxide, foam, or dry chemical
Unsuitable Media: Do not use direct water jet as it may spread material
Hazardous Combustion Products: May produce nitrogen oxides, carbon monoxide, carbon dioxide under intense heat
Protective Equipment: Firefighters use self-contained breathing apparatus with protective clothing
Special Procedures: Cool fire-exposed containers with water spray to prevent bursting, avoid inhalation of decomposition fumes.
Personal Precautions: Equip with gloves, eye protection, and masks, avoid dust formation, ventilate area
Spill Cleanup: Sweep up spilled material into suitable container for disposal, avoid generating airborne dust, wipe surfaces with damp cloth after removal
Environmental Precautions: Prevent material from entering water systems or sewer, contain any large spills with absorbent barriers
Methods for Containment: Use inert absorbent materials, put collected waste in sealed, labeled containers for proper disposal.
Handling: Do not eat, drink, or smoke during use, keep work area clean, wash hands after handling, minimize dust generation
Storage: Store in tightly closed containers, place in a cool, dry, well-ventilated area, keep away from incompatible substances like strong oxidizers or acids, label all storage vessels clearly
Special Requirements: Keep away from sources of ignition, follow basic chemical hygiene protocols at all times.
Engineering Controls: Adequate ventilation or fume hood use suggested in enclosed environments
Respiratory Protection: Use dust mask or respirator with appropriate filters if dust or vapor risk exists
Skin Protection: Wear chemical-resistant gloves, lab coats or overalls
Eye Protection: Safety goggles recommended to avoid eye exposure
Hand Protection: Durable gloves made of nitrile or neoprene
Exposure Limits: No established occupational exposure limits specific for 2,3,5,6-Tetramethyl Pyrazine, maintain levels as low as reasonably practical.
Appearance: White to off-white crystalline solid
Odor: Nutty, roasted scent typical of pyrazines
Melting Point: 87-89°C
Boiling Point: 209°C at 760 mmHg
Solubility: Slightly soluble in water, readily soluble in alcohols and most organic solvents
Vapor Pressure: Very low at room temperature
Density: 1.08 g/cm³
Flash Point: 92°C (closed cup)
Self-Ignition Temperature: Not self-igniting under normal conditions
pH: Not applicable (neutral molecule in solid state).
Stability: Stable under recommended storage conditions
Reactivity: No dangerous reactions known under normal use
Hazardous Reactions: Intense heat or contact with strong oxidizing agents may cause hazardous decomposition
Decomposition Products: Yields carbon oxides and nitrogen oxides during combustion
Conditions to Avoid: Excess heat, sources of ignition, moisture
Incompatible Materials: Strong acids, strong oxidizers may cause violent reactions or degradation of the compound.
Acute Toxicity: Data on oral, dermal, or inhalation toxicity in humans limited, but low acute toxicity observed in animal testing
Skin Corrosion/Irritation: May cause irritation on direct or prolonged contact
Serious Eye Damage/Irritation: Eye contact may produce noticeable discomfort, redness, or tearing
Respiratory Sensitization: Dusts or aerosols can transiently irritate upper respiratory tract
Chronic Exposure: No long-term study data in humans; animal studies show little evidence of chronic harm at low exposure
Carcinogenicity: Not classed as carcinogen by IARC, NTP, or OSHA
Other Health Effects: No recognized risk of mutagenicity or reproductive toxicity.
Aquatic Toxicity: Low; not expected to be acutely toxic to aquatic fauna at typical concentrations
Environmental Mobility: Limited solubility and low vapor pressure reduce potential mobility in soil and water
Persistence and Degradability: Expected to degrade in environment via natural microbial processes
Bioaccumulation: Not expected to accumulate in aquatic organisms
Other Impact: Avoid uncontrolled release to water systems or drains, as local concentrations may exceed ecological thresholds temporarily.
Disposal Method: Collect waste in closed, labeled containers, send for incineration or chemical disposal as hazardous organic waste
Restrictions: Avoid disposal into drains or surface water
Packaging Disposal: Rinse empty containers with water, dispose of according to local regulations governing hazardous materials
Precautions: Prevent formation of dust clouds during transfer, ensure waste contractors recognize chemical identity and hazard classification.
UN Number: Not regulated as hazardous for ground, air, or sea transport
Proper Shipping Name: 2,3,5,6-Tetramethyl Pyrazine
Hazard Class: Not a classified hazard for transport according to DOT, IATA, or IMDG
Packing Group: Not assigned
Transport Precautions: Keep container sealed, protected from crushing, vibration, moisture, and sources of contamination during transit
Labeling: Standard chemical labeling per consignment and regulatory requirements; no mandatory hazardous labels for typical shipments.
International Inventory Status: Listed on TSCA (USA), EINECS (EU), DSL/NDSL (Canada), ENCS (Japan), other national inventories
SARA Title III: Not subject to Section 302, 304, or 313 reporting
OSHA Status: Not regulated as hazardous chemical under OSHA standard
REACH Status: Registered substance; not flagged as a Substance of Very High Concern
California Prop 65: Not listed
Other Regulatory Notes: Use in food regulated by relevant food safety bodies (e.g. FDA, EFSA) due to presence as a flavor additive; consult local, state, and national regulations on workplace safety and chemical handling.
