Material Safety Data Sheet for 2-(2-Piperazin-1-Ylethoxy)Ethanol

Identification

Product Name: 2-(2-Piperazin-1-Ylethoxy)Ethanol
Synonyms: No widely recognized synonyms appear in public chemical registries
CAS Number: 39489-79-7
Recommended Use: Laboratory chemical, intermediate in organic synthesis, research and development
Manufacturer: Supplier information to be provided on demand according to company sourcing
Supplier Contact: Refer to shipping paperwork or certified supplier’s documents for details
Emergency Phone: Refer to relevant national Poison Control and chemical spill emergency lines

Hazard Identification

GHS Classification: Eye Irritation Category 2A, Skin Irritation Category 2, Acute Toxicity Oral Category 4
Signal Word: Warning
Hazard Statements: Causes moderate eye irritation, may cause skin or respiratory irritation, harmful if swallowed
Pictograms: Exclamation mark
Precautionary Statements: Avoid inhalation of dust, do not ingest, wash exposed skin thoroughly, wear appropriate personal protection
Possible Routes of Exposure: Inhalation, skin contact, ingestion, eye contact
Symptoms: Short-term exposure can lead to redness, tearing of the eyes, itching, burning sensations, mild gastrointestinal discomfort if swallowed

Composition / Information on Ingredients

Chemical Identity: 2-(2-Piperazin-1-Ylethoxy)Ethanol
Molecular Formula: C8H18N2O2
CAS Number: 39489-79-7
Concentration: ≥98% (as supplied in commercial or lab-grade lots)
Impurities: Minor process impurities, less than 2%, no other substances classified as hazardous to health present above cut-off values

First Aid Measures

Inhalation: Remove exposed individual to fresh air, keep at rest; seek medical attention if experiencing coughing or difficulty breathing
Skin Contact: Remove contaminated clothing immediately, flush exposed area with running water for at least 15 minutes, call medical help for persistent irritation
Eye Contact: Rinse immediately and continuously with plenty of water for at least 15 minutes, hold eyelids open, seek prompt medical attention
Ingestion: Rinse mouth, do not induce vomiting, offer water if the victim is conscious, consult a Poison Center or a physician without delay
Most Important Symptoms: Redness, burning sensation, nausea, drowsiness in high exposures
Medical Attention: Provide details of exposure and material to medical responders

Fire-Fighting Measures

Suitable Extinguishing Media: Dry chemical, CO2, foam, water spray
Hazards from Combustion: May emit carbon oxides, nitrogen oxides, irritating fumes when heated or combusted
Special Protective Equipment: Firefighters should wear full protective clothing, positive pressure self-contained breathing apparatus
Precautions for Firefighters: Approach fire from upwind to avoid hazardous decomposition fumes, use water spray to keep containers cool
Explosion Data: Not classified as an explosion hazard, but dust or fine mist could ignite under specific conditions

Accidental Release Measures

Personal Precautions: Wear gloves, eye protection, respiratory protection if airborne dust forms
Containment: Isolate spill area, keep unnecessary personnel away
Spill Procedures: Prevent further leakage or spillage, absorb with inert material (sand, earth), sweep or shovel material into suitable containers for proper disposal
Cleaning: Wash residue away with plenty of water, avoid direct contact
Environmental Precautions: Prevent from entering drains, waterways, or soil

Handling and Storage

Precautions for Safe Handling: Avoid direct skin and eye contact; handle in well-ventilated areas, wear lab coat or coveralls
Hygiene Measures: Do not eat, drink, or smoke when using this substance; wash hands and face after handling
Storage Conditions: Store in tightly closed containers, in a cool, dry, and well-ventilated place, protected from sunlight and incompatible substances
Incompatible Materials: Strong oxidizing agents, acids
Packaging: Use containers resistant to organic amines and sealed to prevent moisture ingress

Exposure Controls and Personal Protection

Occupational Exposure Limits: No established national or international exposure limits for this compound
Engineering Controls: Use fume hoods, local exhaust ventilation, and proper laboratory engineering controls
Respiratory Protection: Approved respirators for chemical handling if dust or vapors are generated
Skin Protection: Chemical-resistant gloves, lab coat, long sleeves
Eye Protection: Safety goggles or face shield
Other Protective Equipment: Suitable footwear and emergency eyewash/shower accessible

Physical and Chemical Properties

Appearance: Colorless to pale yellow liquid
Odor: Faint amine-like
Melting Point: Between 10°C and 16°C
Boiling Point: Approx. 250°C at atmospheric pressure
Flash Point: Estimated 176°C (closed cup)
Solubility in Water: Miscible
Vapor Pressure: Low, negligible at room temperature
Relative Density: Around 1.08 – 1.11 g/cm³ at 20°C
pH (dilute aqueous): Mildly basic
Viscosity: Moderate for an alkanolamine

Stability and Reactivity

Chemical Stability: Stable under typical storage and handling conditions
Reactivity: Not highly reactive with most common substances
Hazardous Reactions: May react with strong oxidizers or acids leading to heat generation
Decomposition Products: At high temperatures, can yield carbon oxides, nitrogen-containing gases
Conditions to Avoid: Excess heat, open flames, moisture contact during long-term storage

Toxicological Information

Likely Routes of Exposure: Inhalation, ingestion, dermal and ocular
Acute Toxicity: Data on related compounds suggest oral LD50 for rats around 1000–2000 mg/kg, indicating moderate toxicity
Skin Irritation: Causes moderate skin irritation in animal studies
Eye Irritation: Causes severe eye irritation in rabbit eye models
Respiratory Effects: Inhalation above recommended exposure limit may lead to irritation of upper respiratory tract
Chronic Effects: No long-term toxicity studies available; by analogy to similar amines, significant systemic effects not expected at low exposure levels
Sensitization: Not known to induce sensitization
Carcinogenicity/Mutagenicity/Reproductive Toxicity: Not classified as carcinogenic, mutagenic or reproductive hazard by IARC, NTP or EU CLP

Ecological Information

Ecotoxicity: Short-term aquatic toxicity estimated low to moderate with LC50 (fish 96h) likely in the range 10-100 mg/L
Persistence and Degradability: Expected to be readily biodegradable in environmental conditions based on structure
Bioaccumulation Potential: Not expected to bioaccumulate — low log Kow value
Mobility in Soil: High solubility points to likely availability for leaching to groundwater if released extensively
Other Ecological Effects: Avoid large releases to water bodies to prevent oxygen depletion, carry out controlled disposal

Disposal Considerations

Waste Treatment Methods: Collect and contain material, dispose through licensed chemical waste disposal contractor
Disposal of Packaging: Rinse thoroughly, dispose of as chemical waste
Product Disposal: Avoid disposal to landfill, incineration preferred by certified company
Precautions: Ensure compliance with local, regional and national regulations

Transport Information

UN Number: Not assigned for this compound in ADR, IATA, IMDG
Transport Hazard Class: Not regulated for land, sea or air transport in most jurisdictions Packaging Group: Not regulated Marine Pollutant: Not designated Special Precautions: Ensure containers are upright, closed and appropriately labelled during transport, avoid incompatible shipments

Regulatory Information

Inventory Status: Listed in select chemical inventories; check national databases for specific regulations
Workplace Classification: Subject to chemical control and worker health legislation in most countries Labeling Requirements: Chemical name, appropriate pictograms, signal word, hazard statements, and handling instructions per GHS guidelines
Restrictions: Observe sector-specific guidelines for use and disposal
SDS Availability: Up-to-date SDS must be accessible to all users in the workplace