Product Name: 2,2,6,6-Tetramethyl-4-Oxopiperidinooxy
Chemical Name: 2,2,6,6-Tetramethyl-4-piperidone-N-oxyl
Synonyms: TEMPO, 2,2,6,6-Tetramethylpiperidin-1-oxyl-4-one
CAS Number: 3317-18-0
Recommended Use: Laboratory reagent, oxidation catalyst
Supplier and Contact Details: Manufacturer information, emergency contact number, address provided on packaging
Hazard Class: Acute toxicity (oral, dermal, inhalation), eye irritation, environmental hazard
GHS Label Elements: Pictogram – exclamation mark, aquatic hazard
Signal Word: Warning
Hazard Statements: Harmful if swallowed, causes eye irritation, harmful to aquatic organisms with long-lasting effects
Precautionary Statements: Avoid breathing dust or vapors, wash hands thoroughly, use only outdoors or in a well-ventilated area, avoid release to the environment
Other Information: Contact with water or humidity may cause slow decomposition, storage in tightly closed container advised
Chemical Identity: 2,2,6,6-Tetramethyl-4-Oxopiperidinooxy
Ingredient: 2,2,6,6-Tetramethyl-4-piperidone-N-oxyl
Concentration: 98–100% (pure substance)
Impurities: Trace organic byproducts, typically less than 1%
Mixtures: Not applicable for pure substance
Inhalation: Move to fresh air, keep individual at rest, seek medical attention if symptoms appear, provide oxygen if breathing becomes difficult
Skin Contact: Remove contaminated clothing, rinse skin thoroughly with water and soap, seek medical advice if irritation develops
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses if present and easy to do, continue rinsing, seek medical attention for persistent discomfort
Ingestion: Rinse mouth, do not induce vomiting, drink water if conscious, seek immediate medical advice
Most Important Symptoms: Irritation to eyes, respiratory tract discomfort, possible mild skin irritation
Suitable Extinguishing Media: Water spray, foam, dry chemical powder, carbon dioxide
Unsuitable Media: Strong water jets
Specific Hazards from Fire: May release toxic fumes including nitrogen oxides, carbon monoxide, carbon dioxide
Protective Equipment for Firefighters: Self-contained breathing apparatus, full protective clothing
Special Firefighting Instructions: Clear area, stay upwind, avoid inhalation of fumes, prevent run-off from entering drains or watercourses
Personal Precautions: Evacuate unnecessary personnel, avoid dust formation, ventilate area, wear personal protection such as gloves and eye protection
Environmental Precautions: Prevent product from reaching drains, surface water, or soil, contain spill with inert material
Clean-Up Methods: Pick up with shovel or vacuum, place in a suitable closed container for disposal, decontaminate area with ample water and detergent
Reference to Other Sections: Refer to handling, storage, and disposal instructions
Handling: Use with adequate ventilation, avoid dust and skin contact, open containers carefully, keep away from food and drink
Storage Conditions: Store in cool, dry, well-ventilated area away from direct sunlight, oxidizing agents, and incompatible substances, keep container tightly sealed
Specific Requirements: Use corrosion-resistant, labeled containers, secure area against unauthorized access
Incompatibilities: Strong acids, bases, and oxidizers may react dangerously
Control Parameters: No established occupational exposure limits
Engineering Controls: Enclosed process, local exhaust ventilation, safety showers, emergency eyewash stations
Personal Protective Equipment: Nitrile gloves, chemical splash goggles, protective lab coat, dust mask or respirator for high dust levels
Hygiene Measures: Wash hands and exposed skin after handling, do not eat, drink, or smoke during use
Monitoring: Regularly monitor air quality if large amounts are handled
Appearance: Red to orange crystalline solid or powder
Odor: Mild, slightly pungent
Odor Threshold: Not determined
pH Value: Not applicable (solid substance)
Melting Point/Range: Approximately 36–38°C
Boiling Point/Range: Not available, decomposes
Flash Point: Not flammable under normal conditions
Evaporation Rate: Not applicable
Flammability: Not classified as highly flammable
Explosion Limits: No data available
Vapor Pressure: Low, estimated negligible at room temperature
Vapor Density: Not available
Relative Density: About 1.1–1.2 g/cm³
Water Solubility: Slightly soluble
Partition Coefficient: Log Pow ~0.03 (low potential for bioaccumulation)
Auto-Ignition Temperature: Not available
Decomposition Temperature: Over 60°C, releases hazardous vapors
Viscosity: Not relevant
Chemical Stability: Stable at ambient temperatures if kept dry, decomposes under heat, moisture accelerates breakdown
Reactivity: Reacts with strong acids, bases, and oxidizing agents
Incompatible Materials: Reactive metals, reducing agents, strong oxidizers
Hazardous Decomposition Products: Nitrogen oxides, carbon monoxide, small amounts of other organics possible on burning
Polymerization: Not known to occur
Acute Toxicity: Oral LD50 (rat) estimated 500–2000 mg/kg Body Weight
Routes of Exposure: Inhalation, ingestion, skin, and eye contact
Skin Corrosion/Irritation: Mild irritation possible with repeated contact
Serious Eye Damage/Irritation: Causes eye irritation
Respiratory Sensitization: No data for respiratory sensitization; dust may irritate respiratory tract
Germ Cell Mutagenicity: No significant findings in available studies
Carcinogenicity: Substance not classified as carcinogen by IARC, NTP, or OSHA
Reproductive Toxicity: No evidence of reproductive toxicity in current literature
Specific Target Organ Toxicity: No target organ effects identified in limited studies
Other Effects: Possible oxidative stress in in vitro systems, significance in humans unknown
Aquatic Toxicity: Harmful to aquatic life, chronic toxicity data suggest risk for aquatic organisms
Persistence and Degradability: Moderately persistent, slow biodegradation
Bioaccumulation Potential: Low, based on Log Pow and observed environmental behaviors
Mobility in Soil: Very limited, substance binds to soil particles
Other Adverse Effects: May form degradation products in water and soil
Waste Treatment Methods: Disposal through qualified chemical waste contractor, observe local and national regulations
Contaminated Packaging: Dispose in accordance with local regulations, ensure all packaging is rinsed and labeled
Special Precautions: Do not dispose of in household garbage or sewage system, collect spilled materials for incineration
Recycling Information: Not generally recycled due to specific hazards
UN Number: Not regulated as dangerous under major transport codes (ADR/RID, IMDG, IATA)
UN Proper Shipping Name: Not subject to transport regulations as a hazardous material
Transport Hazard Class: Not classified
Packing Group: Not assigned for transport
Environmental Hazards: Take precautions to prevent environmental release during transport
Transport in Bulk: Not applicable for this chemical
OSHA Hazard Communication: Classified as hazardous chemical according to OSHA Hazard Communication Standard
TSCA Inventory: Listed or otherwise compliant under TSCA regulations
REACH Status: Exempt or preregistered for laboratory use, check supplier for details
Canadian WHMIS Classification: D2B (Toxic Material Causing Other Toxic Effects)
SARA Title III / Section 313: Not listed as a reportable substance
California Proposition 65: Not listed
Other National/Local Regulations: Subject to regulations on chemical storage and disposal, environmental protection law
