Chemical Name: 1-N-Boc-Piperazine
Synonyms: tert-Butoxycarbonyl piperazine, N-tert-Butoxycarbonyl piperazine
CAS Number: 57260-71-6
Recommended Use: Used mainly in chemical synthesis as a protecting group, essential for lab research and pharmaceutical intermediate steps.
Supplier Details: Refer to your trading source or lab procurement contact.
Emergency Contact: Regional Poison Control Center or company safety office; keep information near any working station.
Classification: Not classified as hazardous by GHS, but handle with caution because dust or vapor may irritate eyes, skin, or airways.
Signal Word: None required under GHS criteria; keep alert to local regulatory changes.
Pictograms: Not required, but safe handling pictograms may assist lab safety.
Hazard Statements: May cause temporary discomfort if inhaled or gets in eyes; not known to cause chronic toxicity but untested for every route.
Precautionary Statements: Wear gloves, use eye protection, and limit dust formation to minimize accidental contact or inhalation issues.
Ingredient: 1-N-Boc-Piperazine
Concentration: Pure compound unless otherwise noted in supplier’s packaging.
Impurities: Minimal unless noted by batch certificate; avoid cross-contamination by storing separately from other piperazine compounds.
Molecular Formula: C9H18N2O2
Molecular Weight: 186.25 g/mol
Eye Contact: Rinse eyes gently with tap water for at least 10 minutes, holding eyelids wide; seek medical help if irritation continues.
Skin Contact: Remove contaminated clothing and rinse skin under running water; wash with soap; consult health personnel if rash or discomfort grows.
Inhalation: Move person to fresh air at once and keep at rest; seek medical advice if coughing or breath trouble continues.
Ingestion: Rinse mouth thoroughly; never give liquid to an unconscious person; get medical attention as a precaution, especially if discomfort occurs.
Advice to Physicians: Treat symptomatically as there is no known antidote; monitor breathing, skin health, and fluid intake.
Suitable Extinguishing Media: Use foam, CO2, dry chemical, or water fog for small fires; water spray may help cool containers but avoid direct water jet.
Specific Hazards: May form hazardous fumes if burned, such as nitrogen oxides or carbon monoxide; avoid inhalation of smoke.
Special Protective Actions: Wear self-contained breathing equipment and protective suit; keep away from area unless trained in fire response.
Advice for Firefighters: Control run-off to minimize environmental impact; ventilate area after fire, as chemical residues may still pose risk.
Personal Precautions: Wear gloves, lab coat, goggles; use particle mask if dust is expected; ventilate area before starting cleanup.
Containment: Avoid spreading dust; use absorbent material for any spilled liquid.
Cleanup: Scoop or sweep up solid and place in labelled waste container; wipe surfaces with wet cloth to eliminate residue.
Environmental Precautions: Prevent entry into drains or water sources; gather waste for safe disposal; report large spills to authorities as needed.
Handling: Use in chemical fume hood or well-ventilated area; avoid eating, drinking, or smoking in work area; keep away from strong acids and oxidizers.
Storage: Store in cool, dry, well-ventilated space; keep tightly sealed in original container; label all storage vessels properly to avoid confusion.
Incompatibilities: Keep separate from strong acids, strong bases, and oxidizing agents; avoid sources of ignition or direct sunlight over prolonged periods.
Safe Practices: Make regular checks for leaks, corrosion, or unwanted residues in and around the storage zone.
Engineering Controls: Run processes in fume hood; ensure local ventilation reduces dust or vapor exposure.
Personal Protective Equipment: Gloves (nitrile or latex preferred); chemical splash goggles; standard lab coat; dust mask if working with powder.
Occupational Exposure Limits: Not established, but minimize exposure as with other synthetic intermediates.
Environmental Controls: Prevent escape to environment; use closed transfer systems wherever possible.
Appearance: White crystalline or powdery solid.
Odor: Weak or absent, not distinctive.
Melting Point: About 90–92°C, based on supplier data.
Boiling Point: Not meaningful under atmospheric conditions as decomposition occurs.
Solubility: Slightly soluble in water, more soluble in common organic solvents (e.g. DMSO, methanol).
Density: About 1.0–1.1 g/cm3, depending on batch and form.
pH: Not relevant in normal use; neutral in most solvents.
Other Properties: Stable under standard conditions, non-volatile at room temperature.
Chemical Stability: Stable when dry and stored at room temperature; unstable with prolonged exposure to strong acids or bases.
Conditions to Avoid: High humidity, heat above 50°C, and contact with incompatible materials.
Incompatible Materials: Strong oxidizers, strong acids, strong bases.
Hazardous Decomposition: May give off carbon oxides, nitrogen oxides under fire or decomposition; avoid burning.
Routes of Exposure: Eye, skin, inhalation, ingestion.
Acute Effects: May cause mild to moderate irritation to eyes, airways, or skin during direct exposure.
Chronic Effects: No long-term studies completed; practice standard precautions to avoid repeated contact.
Sensitization: Low likelihood; monitor for rare skin reactions.
Carcinogenicity/Mutagenicity: Not listed by IARC, NTP, or OSHA as known carcinogen.
Toxicological Data: Limited human or animal toxicology data; handle as potentially harmful until more evidence is available.
Ecotoxicity: No detailed studies, but avoid release to environment because chemical synthesis intermediates often affect aquatic life.
Persistence/Degradability: Expected to degrade slowly in soil or water; remove using reliable containment and waste processing.
Bioaccumulation: Not expected to build up in organisms, but prudent handling reduces risks.
Soil Mobility: Likely low because of moderate water solubility; avoid contamination of large volumes of soil or water.
Disposal Methods: Place residues and waste material in labelled hazardous waste bags or drums; send to licensed chemical waste disposal plant.
Container Disposal: Rinse empty containers three times before disposal; crush or puncture to prevent reuse.
Special Precautions: Never pour down drain; incineration preferred if local regulations permit.
Legal Requirements: Follow local, national, and institutional waste disposal rules for laboratory chemicals and hazardous compound residues.
Proper Shipping Name: 1-N-Boc-Piperazine (or laboratory chemical, if no specific code applicable).
UN Number: Not assigned; shipped as non-regulated material under most mainstream transport codes.
Hazard Class: Not regulated as hazardous for transport, but avoid mixing with incompatible cargo.
Packing Group: Not required.
Transport Precautions: Keep container sealed, secured, and clearly labelled; avoid extreme heat or cold in transit.
TSCA: Listed or exempt; lab-use chemicals sometimes excluded from routine commercial notification.
EINECS/ELINCS: Present or notified depending on jurisdiction.
Workplace Regulations: Subject to OSHA or local occupational health standards; check local and national requirements.
REACH Status: Check supplier REACH registration, if relevant for EU markets.
Other Rules: Package and ship according to laboratory safety office policies, not as a consumer product.
