Product Name: 1-Methylpyrrolidin-3-ol
Synonyms: N-Methyl-3-hydroxypyrrolidine
Recommended Use: Laboratory chemicals, research, fine chemical synthesis
CAS Number: 3760-65-2
Supplier: Chemical manufacturing, research suppliers, specialty chemical distributors
Contact Information: 24-hour emergency contact through local chemical safety authorities or institutional safety offices
Classification: Flammable liquid (Category 3), Acute toxicity (Category 4, oral and dermal), Eye irritation (Category 2A), Skin irritation (Category 2)
GHS Label Elements: Signal word: Warning, Hazard statements: Flammable liquid and vapor, Harmful if swallowed or in contact with skin, Causes skin and eye irritation
Precautionary Statements: Avoid inhalation, avoid contact with eyes, skin, and clothing, keep away from heat, sparks, open flames, and hot surfaces
Potential Health Effects: May cause headache, nausea, or respiratory tract irritation, can lead to redness and pain if in contact with skin or eyes
Chemical Name: 1-Methylpyrrolidin-3-ol
CAS Number: 3760-65-2
Concentration: >98% purity typical for laboratory and industrial settings
Impurities: Trace related alkylpyrrolidines, moisture from exposure to air
Molecular Formula: C5H11NO
Inhalation: Move person to fresh air, seek medical attention for signs of breathing difficulty, monitor for symptoms like dizziness or headaches
Skin Contact: Remove contaminated clothing, rinse skin under running water, wash thoroughly with soap, seek medical help for persistent irritation
Eye Contact: Rinse immediately with plenty of water for at least 10 minutes, keep eyelids open, obtain professional medical evaluation
Ingestion: Rinse mouth, never give anything by mouth to an unconscious person, do not induce vomiting, seek immediate medical attention
Note to Physician: Symptomatic treatment, monitor for respiratory irritation or systemic effects
Suitable Extinguishing Media: Use foam, dry chemical powder, or carbon dioxide for small fires, water spray for large scale incidents
Hazards from Combustion Products: Releases carbon oxides, nitrogen oxides, potentially toxic vapors
Protective Gear: Use full protective clothing, self-contained breathing apparatus, avoid inhalation of combustion products
Special Procedures: Evacuate area, cool fire-exposed containers with water, take care to prevent contamination of water sources
Personal Precautions: Evacuate non-essential personnel, ventilate area, avoid contact with spilled material, wear personal protective equipment
Environmental Precautions: Prevent run-off into sewers and waterways, contain spillage with non-combustible materials like sand
Clean-Up Methods: Absorb with inert material, transfer to sealed container for disposal, wash area after collection completes
Disposal: Handle as hazardous waste, follow institutional protocols, contact licensed disposal vendors
Handling: Work with 1-methylpyrrolidin-3-ol in a chemical fume hood, use gloves and protective eyewear, avoid generating mists or vapors, do not eat or drink near the working area, follow standard chemical safety protocols used in research and industrial labs
Storage: Store in tightly sealed original containers, keep in a cool dry ventilated place, segregate from strong oxidizers and acids, ensure label remains intact, maintain compliant storage conditions according to fire safety guidelines, protect from direct sunlight and static discharge sources
Exposure Limits: No established occupational exposure limits for this compound, follow general exposure guidelines for organic solvents and amines
Engineering Controls: Use with local exhaust ventilation, regularly check for leaks or accumulated vapors, monitor air for hazardous levels inside workspaces
Personal Protective Equipment: Wear chemical-resistant gloves (like nitrile), splash-proof goggles, long lab coats, closed-toe shoes, use face shields for bulk handling or splashing risk, ensure safety showers and eyewash stations remain accessible
Hygienic Measures: Wash hands immediately after handling, change contaminated clothing promptly, avoid skin contact, prohibiting eating, drinking, or smoking in working spaces
Form: Clear to slightly yellow liquid
Odor: Mild amine-like
pH: Not readily determined in neutral water
Boiling Point: 188–190°C
Melting Point: Below room temperature
Flash Point: 69°C (open cup, approximate)
Relative Density: ~0.99 g/cm³ at 20°C
Solubility: Miscible with water and many organic solvents
Vapor Density: No data available; likely heavier than air
Vapor Pressure: Low at ambient temperature
Partition Coefficient (log Pow): Not well established for this compound, expected low
Viscosity: Slightly more viscous than water at room temperature
Chemical Stability: Stable under recommended handling and storage conditions, degrades slowly in presence of strong acids or oxidizers
Conditions to Avoid: Open flames, static discharge, direct sunlight, excessive moisture
Incompatible Materials: Strong oxidizing agents, strong acids, certain chlorinated reagents
Hazardous Decomposition Products: Burning produces carbon monoxide, carbon dioxide, nitrogen oxides, possibly other harmful vapors
Polymerization: Not expected under normal conditions
Acute Toxicity: May cause moderate toxicity by oral, dermal, or inhalation routes in animal models, estimated LD50 (oral, rat) in the range of 300–2,000 mg/kg
Skin & Eye Irritation: Causes noticeable redness or pain upon contact
Respiratory Effects: Exposure to mists can irritate airways
Sensitization: No reliable evidence of allergic skin response
Chronic Effects: No long-term studies in humans; avoid repeated unprotected exposure
Carcinogenicity & Reproductive Toxicity: Not listed by IARC, NTP, OSHA, or EPA; no data for chronic or reproductive toxicity
Other Information: Observed symptoms may include gastrointestinal discomfort, headache, drowsiness
Ecotoxicity: Limited information available, possible moderate toxicity to aquatic organisms based on structural analogy
Persistence and Degradability: Expected to biodegrade under aerobic conditions, but slow under anaerobic systems
Bioaccumulative Potential: Low, due to water solubility and anticipated rapid breakdown
Mobility in Soil: Likely to migrate through soil into groundwater
Other Adverse Effects: Avoid release to waterways, minimize environmental contamination by routine controls during use and disposal
Product Disposal: Send to licensed chemical disposal facility, avoid discharge into waterways or sewers
Contaminated Packaging: Remove residual product, comply with institutional hazardous waste disposal procedures, triple-rinse with appropriate solvent if feasible before disposal
Waste Codes: Consult regional regulations for proper waste identification and handling
Special Precautions: Limit exposure to vapor during waste transfer, use secondary containment when collecting liquid waste
UN Number: Not routinely assigned due to low commercial transport frequency, but may require assignment as a flammable liquid
Hazard Class: 3 (Flammable liquids), due to flash point below 93°C
Packing Group: III (medium danger), based on flammability and toxicity
Environmental Hazards: Not classified as a marine pollutant
Transport Labels: Flammable liquid
Special Precautions: Ship in approved containers, avoid movement near heat sources or open flames, comply with international and local transport guidelines (IATA, DOT, IMDG)
US Regulations: Not specifically listed under TSCA, SARA, CERCLA regulations; reportable quantities based on site protocols
EU Regulations: Should be handled in accordance with REACH, not included in Annex XVII restrictions or SVHC list
Canada: DSL/NDSL: Not listed specifically, may be subject to notification
Other Regions: Local authorities may provide additional labeling or documentation requirements
Workplace Labeling: Clearly identify containers, keep updated MSDS available to staff
Worker Protection: Meet requirements for hazardous chemical handling, provide documented training and annual reviews on chemical hygiene
