Product Name: 1-Methylpiperazine
Chemical Formula: C5H12N2
Chemical Family: Aliphatic amine
Synonyms: N-Methylpiperazine
CAS Number: 109-01-3
UN Number: UN 2734
Relevant Identified Uses: Laboratory use, intermediate in organic synthesis, pharmaceutical production
Supplier Details: Manufacturer address, Emergency contact number, Email contact for technical support
GHS Classification: Flammable liquids (Category 3), Acute toxicity oral (Category 4), Skin corrosion/irritation (Category 1B), Serious eye damage (Category 1), Acute toxicity inhalation (Category 4)
Label Elements: Flame symbol, Corrosive symbol
Signal Word: Danger
Hazard Statements: Harmful if swallowed, Causes severe skin burns and eye damage, Harmful if inhaled, Flammable liquid and vapor
Precautionary Statements: Avoid breathing vapors, Avoid release to the environment, Wear protective gloves and clothing, Use explosion-proof equipment, Keep container tightly closed
Potential Health Effects: Inhalation causes sore throat, cough, headache; skin contact leads to burns; eye exposure results in redness, pain, severe injury; ingestion induces abdominal pain and vomiting
Target Organs: Respiratory system, Skin, Eyes, Gastrointestinal tract
Chemical Name: 1-Methylpiperazine
Concentration: >97% (by weight)
CAS Number: 109-01-3
Impurities: Trace levels of piperazine, water (<1%), typical byproducts of synthesis
Other Components: No hazardous components present above reportable limits
Inhalation: Move person to fresh air, keep comfortable for breathing, seek immediate medical attention if symptoms appear
Skin Contact: Remove contaminated clothing, rinse skin with plenty of water for at least 15 minutes, call medical services
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses if present and easy to do, continue rinsing, get emergency medical help
Ingestion: Rinse mouth, do not induce vomiting, never give anything by mouth to an unconscious person, seek rapid medical attention
Symptoms and Effects: Burning sensation, coughing, chest pain, skin and eye burns, nausea, dizziness
Notes to Physician: Symptomatic treatment and supportive therapy as indicated, monitor for respiratory distress and chemical burns
Special Precautions for First Responders: Use personal protective equipment appropriate for the situation, avoid exposure to bodily fluids and chemical residue
Suitable Extinguishing Media: Alcohol-resistant foam, dry chemical powder, carbon dioxide, water spray (use caution with water due to reactivity)
Specific Hazards from Fire: Vapors may form explosive mixtures with air, hazardous decomposition includes nitrogen oxides, carbon monoxide, carbon dioxide
Protective Equipment for Firefighters: Firefighters should wear self-contained breathing apparatus, full-body fire and chemical resistant suits
Fire Fighting Instructions: Remove containers from fire area if safe to do so, cool exposed containers with water spray, prevent run-off from entering drains and water sources
Unusual Fire Hazards: Combustion produces irritating, toxic fumes, risk of violent rupture of containers under intense heat
Personal Precautions: Evacuate area, ventilate surroundings, avoid inhalation of vapors, prevent skin and eye contact, use appropriate PPE (chemical resistant gloves, goggles, respirator)
Environmental Precautions: Prevent release to soil, water courses and drains, contain and collect spillage for proper disposal
Clean-Up Procedures: Absorb with inert material (sand, earth, vermiculite), collect for disposal in suitable containers, decontaminate area with plenty of water and detergent
Spill Response: Approach upwind, establish cordon zone, cover liquid spills with absorbents, avoid use of organic materials for clean-up due to possible reactivity
Decontamination: Wash all exposed surfaces with copious water, ventilate the contaminated area, ensure removal of all residue before re-use of premises
Safe Handling: Use only in well-ventilated areas, keep away from heat, sparks, open flames and hot surfaces, avoid contact with skin, eyes and clothing, prevent formation of dust or aerosols, keep container closed when not in use
Personal Hygiene: Wash hands and face thoroughly after handling, remove contaminated clothing and wash before reuse
Storage Conditions: Store in cool, dry, well-ventilated area, keep away from incompatible materials such as acids, oxidizers, strong bases, store in original tightly closed containers, maintain proper labeling
Incompatibilities: Avoid contact with strong acids, anhydrides, oxidizing agents, halogens, acid chlorides
Storage Life: Stable under recommended storage conditions, monitor regularly for container integrity
Occupational Exposure Limit: No official OSHA or ACGIH limits currently established, recommend use of workplace exposure monitoring
Engineering Controls: Local exhaust ventilation, closed processes where practical, safety shower and eyewash stations nearby, explosion-proof electrical systems
Respiratory Protection: Approved respirator with organic vapor/acid gas cartridges, especially where ventilation does not reduce exposure below recommended levels
Skin Protection: Chemical-resistant gloves (butyl rubber, nitrile), long-sleeved protective clothing, apron, chemical-resistant boots
Eye Protection: Splash-proof safety goggles or face shield
Hand Protection: Impervious gloves replaced regularly when worn or contaminated
General Hygiene Measures: Do not eat, drink or smoke in work area, immediate washing after exposure, regular training on chemical risks and safe handling
Appearance: Clear to pale yellow liquid
Odor: Ammonia-like, pungent
Odor Threshold: Not determined, strong odor detectable at low concentrations
pH: Alkaline, typically 10-12 (aqueous solution)
Melting Point: -57°C
Boiling Point: 138-140°C
Flash Point: 39°C (closed cup)
Evaporation Rate: Not available
Flammability: Flammable liquid, burns with yellowish flame
Upper/Lower Explosion Limits: Lower 1.3% by volume, Upper 7.6% by volume
Vapor Pressure: 7.1 mm Hg at 20°C
Vapor Density: 2.8 (air = 1)
Relative Density: Approximately 0.87 g/cm³ at 20°C
Solubility: Miscible with water, soluble in organic solvents (ethanol, ether)
Partition Coefficient (log Kow): -0.39
Auto-Ignition Temperature: 280°C
Decomposition Temperature: Not specified, decomposes above 200°C
Viscosity: 0.89 mPa·s at 25°C
Chemical Stability: Stable under recommended storage and handling procedures, sensitive to moisture and strong acids
Reactivity: Highly reactive with acid chlorides and oxidizing agents, exothermic reactions possible on contact
Hazardous Polymerization: Not expected to occur under normal conditions
Hazardous Decomposition Products: Nitrogen oxides, carbon oxides, ammonia, toxic fumes
Conditions to Avoid: Heat, sparks, flames, static electricity, incompatible materials
Incompatible Materials: Acid halides, strong oxidizing agents, strong acids, peroxides, chlorine, anhydrides
Corrosivity: Corrosive to skin, eyes, mucous membranes; attacks some metals upon prolonged contact
Acute Toxicity: Oral LD50 (rat): 640 mg/kg, Dermal LD50: not adequately studied, Inhalation toxicity not fully established
Skin Corrosion/Irritation: Causes severe burns, ulceration, blistering in animal studies
Eye Damage/Irritation: Severe eye damage, risk of blindness
Respiratory Sensitization: Inhalation results in respiratory tract irritation, possible lung edema at high concentrations
Carcinogenicity: Not classified as a carcinogen by IARC, NTP, or OSHA
Mutagenicity: No evidence in available short-term tests
Reproductive Toxicity: Data not conclusive, not listed as a reproductive hazard
STOT (Specific Target Organ Toxicity) – Single Exposure: May cause drowsiness, dizziness, or nausea
STOT – Repeated Exposure: Prolonged exposure may result in damage to the respiratory lining, kidney or liver effects at massive doses
Aspiration Hazard: Unlikely under normal use conditions, possible risk with large volume ingestion
Symptoms of Overexposure: Skin and eye burns, sore throat, headache, breathing difficulty, gastrointestinal distress
Ecotoxicity: Harmful to aquatic organisms, results in acute toxicity in aquatic invertebrates at low concentrations, fish LC50 (96h): ~50 mg/L (estimated)
Persistence and Degradability: Moderately biodegradable in soil and water with exposure to air and sunlight
Bioaccumulative Potential: Low, based on log Kow and water solubility
Mobility in Soil: High mobility due to miscibility in water, potential to reach groundwater
Other Adverse Effects: Slight alkaline reaction could disturb natural water pH, risk to sewage treatment systems at high concentrations
Results of PBT/vPvB Assessment: Not identified as persistent, bioaccumulative, or toxic based on available information
Waste Treatment Methods: Dispose of as hazardous chemical waste in accordance with local, regional, national regulations; do not dispose to sewers, drains, or the environment
Recommended Disposal: Incineration in a licensed chemical incinerator equipped with afterburner and scrubber systems
Contaminated Packaging: Empty containers present significant hazard, retain hazardous labeling, triple rinse and dispose in accordance with regulations
Precautions for Disposal: Always handle and transport waste using appropriate personal protective equipment, avoid contamination of soil and groundwater
Waste Code: Based on local hazardous chemical codes, consult with waste disposal authorities
UN Number: UN 2734
UN Proper Shipping Name: Amines, liquid, corrosive, flammable, n.o.s. (contains 1-Methylpiperazine)
Transport Hazard Classes: 3 (Flammable Liquid) and 8 (Corrosive Substance)
Packing Group: II
Labels: Flammable liquid, Corrosive
Special Transport Precautions: Keep containers upright and sealed, segregate from foodstuffs, acids, oxidizers
Environmental Hazards: Not classified as marine pollutant, care to prevent leakage into water systems
Transport in Bulk: Follow IMO/IMDG, ADR/RID, and ICAO/IATA guidelines for chemical bulk transport
TSCA Status: Listed on the US Toxic Substances Control Act inventory
EINECS/ELINCS: Listed under number 203-641-2
REACH Registration: Registered under European REACH regulation
OSHA Hazard: Classified as hazardous based on flammability and corrosivity
SARA 311/312 Categories: Immediate health hazard, fire hazard
DSL/NDSL (Canada): Present on Domestic Substance List (DSL)
WHMIS Classification: Class B2 (Flammable liquid), Class E (Corrosive material)
Other National/International Regulations: Check specific country requirements, ensure compliance with chemical storage and transport guidelines
