Chemical Name: 1-Methylimidazole
Synonyms: N-Methylimidazole, 1-Methyl-1H-imidazole
CAS Number: 616-47-7
Molecular Formula: C4H6N2
Recommended Use: Intermediate for pharmaceuticals, resin manufacturing, research reagent
Manufacturer and Supplier Details: Listed on container or safety documents, always double-check supply chain records for authenticity
Emergency Contact: Found on label or supporting documentation, includes numbers for chemical emergency response or poison control
GHS Classification: Acute toxicity (Oral, Category 4), Skin Irritation (Category 2), Eye Irritation (Category 2A)
Signal Word: Warning
Hazard Statements: Harmful if swallowed, causes skin irritation, causes serious eye irritation
Pictograms: Exclamation mark
Precautionary Statements: Do not handle without protective gear, avoid breathing vapors, wash hands thoroughly after use, contaminated work clothing should not leave workplace
Symptoms of Exposure: Burning sensation, redness, possible nausea, drowsiness, or headaches from inhalation
Potential Health Effects: Eyes, skin, and respiratory tract can take a beating if exposed directly or in high enough concentration
Substance: 1-Methylimidazole
CAS Number: 616-47-7
Concentration: Pure (over 99%)
Impurities: Less than 1%, varies by supplier; route for trace unknowns via supplier SDS
Additives: None listed in typical lab-grade samples
Inhalation: Remove individual to fresh air right away, keep warm and still, use artificial respiration if breathing gets choked up, call a physician ASAP
Skin Contact: Wash the skin with generous water and soap, strip off contaminated clothing, see a doctor if soreness or irritation holds on
Eye Contact: Hold eyelids open, rinse with lots of water for at least 15 minutes, get medical help even if it seems mild
Ingestion: Rinse mouth, avoid making the person vomit unless a doctor advises, medical attention straight away
Most Important Symptoms: Red eyes, burn or pain on the skin, sore throat, dizziness, possibly stomach upset after swallowing
Suitable Extinguishers: CO2, dry chemical powder, alcohol-resistant foam, water spray works in most firefighting settings
Special Hazards: Combustion gives nasty stuff like nitrogen oxides, carbon monoxide, can dance up some thick smoke
Specific Protective Equipment: Firefighters should grab a self-contained breathing apparatus and full gear since smoke and heat rise fast
Further Advice: Remove surrounding containers from risk if safe, cool drum surfaces with water if they get hot
Personal Precautions: Strong ventilation, use gloves and goggles, don’t touch spilled stuff with bare hands, avoid breathing dust or vapor
Spill Clean-up Methods: Shut off sources of ignition, mop up with absorbent material (vermiculite, sand), shovel residue into chemical waste containers, wash area with lots of water
Environmental Measures: Keep out of drains and waterways, check local spill response regulations, take steps to block chemical moving into soil
Evacuation Procedures: Clear out unnecessary people until clean-up finishes safely
Handling: Wear recommended PPE, keep away from sparks or open flame, use under fume hood if fumes climb, always wash hands after handling work
Storage Conditions: Store sealed containers in cool, ventilated space, keep container upright and tightly closed, separate from foodstuffs or incompatible chemicals (such as strong oxidizers)
Advice for Mixing: Mix only with equipment intended for small-scale lab or industrial use, never in open air
Exposure Limits: No strict OSHA, ACGIH or NIOSH numbers for 1-Methylimidazole but treat as hazardous in local risk assessments
Personal Protective Equipment (PPE): Chemical splash goggles, nitrile or butyl gloves, lab coat or full-body chemical-resistant apron, emergency eye wash stations nearby
Engineering Controls: Chemical fume hood vital, maintain proper ventilation at all times
Respiratory Protection: NIOSH-approved mask if airborne concentration climbs or work involves large volumes
Hygiene Measures: No drinking, eating, or smoking where chemical gets used, wash up before breaks or after handling
Appearance: Colorless to pale yellow liquid
Odor: Mild, amine-like
pH: Around 10 when mixed in water
Melting Point: -60 °C
Boiling Point: 199 °C
Flash Point: 78 °C (closed cup)
Flammability: Flammable liquid
Vapor Pressure: 0.5 hPa at 25 °C
Solubility: Readily mixes with water and alcohol
Density: About 1.03 g/cm³ at 25 °C
Molecular Weight: 82.11 g/mol
Partition Coefficient (n-octanol/water): 0.23
Stability: Stable at most storage temperatures and usual handling if sealed and away from light and air
Reactivity: Avoid contact with strong oxidizing agents
Hazardous Decomposition Products: Emits nitrogen oxides, carbon monoxide, and carbon dioxide under fire or heat
Polymerization: Not prone to dangerous polymerization under normal lab or storage conditions
Conditions to Avoid: Flames, sparks, direct heat, and strong oxidizers
Likely Routes of Exposure: Skin, eyes, mouth, and inhalation from vapor
Acute Toxicity: LD50 (oral, rat) reported as about 970 mg/kg
Potential Health Effects: Short-term skin or eye contact can burn or irritate, if breathed in it can lead to headaches, nausea, or dizziness
Skin Sensitization: Not expected but long exposures can dry or redden skin
Chronic Effects: Not fully studied for long-term problems; repeated high exposures can stress liver and kidneys, according to job safety boards
Carcinogenicity: Not classified as a carcinogen by IARC, NTP, or OSHA
Other Effects: Eyes and upper airway can remain sore long after exposure in sensitive folks
Ecotoxicity: Harmful to aquatic organisms and bugs, especially in high concentrations
Persistence and Degradability: Breaks down slowly in water and air, requires proper treatment in chemical disposal
Bioaccumulation Potential: Low, though best to prevent release into the environment
Mobility in Soil: Moves through soil if spilled, risk to groundwater if released unchecked
Further Information: No broad industrial use in open water settings allowed; follow site-specific guidance for accidental releases
Disposal Methods: Incineration in permitted chemical waste burners best, small quantities—if diluted—may go as hazardous waste per local code
Container Disposal: Rinse, triple-wash, puncture or crush then hand to licensed hazardous waste processor
Precautions: Don’t pour down drain, burn outside of controlled incinerator or throw with mixed trash; document every batch, log weight and transfer
UN Number: 2810
Proper Shipping Name: Toxic Liquid, Organic, N.O.S. (1-Methylimidazole)
Transport Hazard Class: 6.1 (Toxic Substance)
Packing Group: III
Environmental Hazards: Marked “Dangerous for the Environment” on large shipments
Handling Precautions: Keep upright, sealed, mark labels clear, carriers must be briefed
Regulatory Labels: GHS, IATA, IMDG required; stow with caution on trucks and ships, keep away from food and feed cargo
Labeling: Follows OSHA Hazard Communication Standard (29 CFR 1910.1200), GHS, and local right-to-know statutes
Inventory Status: Listed on TSCA, EINECS, and related national chemical lists
SARA 311/312 Hazards: Immediate (Acute) Health Hazard
RCRA Waste Code: Not specifically cited; always treat as hazardous unless local rules say otherwise
Other Local Information: European Annex VI Table 3.1 gives hazard codes, local and state compliance teams may require added reporting, update documentation for every new batch in storage or transit
