Product Name: 1-Methyl-3-Phenyl-1-Piperazine
Synonyms: N-Methyl-3-phenylpiperazine
Chemical Formula: C11H16N2
Molecular Weight: 176.26 g/mol
CAS Number: 5271-27-2
Recommended Use: Laboratory reagent, chemical synthesis intermediate
Supplier: Laboratory supplier or chemical distributor contact details on product label
Emergency Contact: Local poison control center or emergency service, supplier emergency phone number on label
GHS Classification: Acute Toxicity (Oral, Dermal, Inhalation) – Category 4, Eye Irritation – Category 2A, Skin Irritation – Category 2
GHS Label: Exclamation mark symbol
Signal Word: Warning
Hazard Statements: Harmful if swallowed, in contact with skin, or if inhaled. Causes skin irritation. Causes serious eye irritation.
Precautionary Statements: Avoid breathing dust, vapors, or mist. Wash skin and hands thoroughly after handling. Wear protective cloves, clothing, eye and face protection.
Other Hazards: Potentially harmful to aquatic life with long lasting effects. May cause central nervous system effects if overexposed.
Chemical Name: 1-Methyl-3-Phenyl-1-Piperazine
CAS Number: 5271-27-2
Concentration: ≥ 98%
Impurities: Residual solvents & trace by-products from manufacturing, < 2%
Inhalation: Move affected person to fresh air. If breathing becomes difficult, oxygen may be given by trained personnel. Seek medical attention if symptoms persist.
Skin Contact: Remove contaminated clothing. Wash skin thoroughly with soap and water for at least fifteen minutes. If irritation continues, consult a healthcare provider.
Eye Contact: Rinse eyes with clean water for at least twenty minutes. Remove contact lenses if present and easy to do. Seek medical help right away.
Ingestion: Rinse mouth with water. Do not induce vomiting unless directed by medical personnel. Get medical assistance if you feel unwell.
Most Important Symptoms: Redness, burning, pain in eyes or skin, cough, nausea, headache, confusion, drowsiness.
Note to Physician: Provide symptomatic and supportive treatment. Observe for possible delayed effects on central nervous system.
Suitable Extinguishing Media: Water spray, dry chemical powder, carbon dioxide, foam.
Specific Hazards: May produce toxic fumes of nitrogen oxides and carbon oxides under fire conditions. Combustible at high temperatures.
Protection for Firefighters: Use full protective gear and self-contained breathing apparatus.
Additional Advice: Move containers from fire area if you can do it without risk. Prevent discharge of fire control runoff into the environment.
Personal Precautions: Ventilate area. Use personal protective equipment, including gloves, goggles, and suitable clothing.
Environmental Precautions: Prevent entry of chemical into drains, water courses, or soil.
Methods for Cleanup: Absorb small spills with inert material (sand, earth, vermiculite). Sweep or scoop up material and transfer to a suitable container for disposal. Wash spill site after material pickup is complete.
Other Information: Remove all ignition sources if safe to do so. Avoid inhaling dust or vapors.
Handling: Work in a fume hood or well-ventilated area. Avoid direct contact with skin, eyes, and clothing. Do not eat, drink, or smoke while handling chemical. Wash hands after usage.
Storage: Store in tightly closed, clearly labeled containers. Keep container in a dry, cool, and well-ventilated area away from heat, ignition sources, and incompatible substances such as strong oxidizers and acids. Protect from moisture. Store away from food and beverages.
Exposure Limits: No occupational exposure limit established specifically for this compound. Limit workplace airborne concentrations to lowest possible.
Engineering Controls: Use with local exhaust ventilation, chemical fume hood preferred.
Personal Protections: Wear safety goggles or face shield, chemical-resistant gloves, long-sleeved clothing or lab coat, and use respiratory protection if ventilation is inadequate.
Hygiene: Clean hands thoroughly after handling, before eating or drinking. Do not bring contaminated clothing outside work area; launder before reuse.
Appearance: Colorless to pale yellow oily liquid or solid at room temperature
Odor: Mild, amine-like
Melting Point: 11–13°C
Boiling Point: 280–285°C
Flash Point: Approx. 130°C
Solubility: Soluble in water and most organic solvents (methanol, ethanol, chloroform)
Vapor Pressure: Low at room temperature
Density: 1.03–1.07 g/cm³
pH: 8–9 (aqueous solution)
Partition Coefficient (log Kow): No data available
Auto-ignition Temperature: Not established
Upper/Lower Flammability Limit: Data not available
Chemical Stability: Stable under recommended storage conditions
Reactivity: Reacts with oxidizing agents and strong acids
Possibility of Hazardous Reactions: Can form hazardous decomposition products when heated or exposed to fire
Hazardous Decomposition Products: Nitrogen oxides, carbon monoxide, carbon dioxide
Conditions to Avoid: Avoid excessive heat, open flames, strong oxidizers, and moisture
Incompatible Materials: Strong acids, strong oxidizing agents, acyl chlorides, anhydrides
Acute Toxicity: Oral LD50 (rat): approximately 400 mg/kg. Harmful if swallowed, inhaled, or absorbed through skin.
Skin Corrosion/Irritation: Causes skin irritation, may be absorbed through skin causing systemic effects.
Serious Eye Damage/Irritation: Causes irritation with pain and redness.
Respiratory Effects: Inhalation can result in coughing, drowsiness, headaches, and possible central nervous system depression.
Chronic Effects: Prolonged or repeated exposure may affect liver, kidney, or nervous system.
Sensitization: No data available on sensitization.
Carcinogenicity, Mutagenicity, Reproductive Toxicity: No adequate data in humans or animals. Not listed as a carcinogen.
Other Data: Effects can be delayed, central nervous system symptoms can appear hours after exposure.
Ecotoxicity: Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
Persistence and Degradability: Biodegradability not well studied, likely to persist in soil and water.
Bioaccumulation Potential: Not expected to bioaccumulate significantly, specific studies unavailable.
Mobility in Soil: High solubility in water suggests mobility in soil and groundwater possible.
Other Adverse Effects: Discharge to the environment should be avoided, even small quantities can be hazardous to aquatic life.
Waste Treatment Methods: Treat as hazardous waste, collect in clearly labeled container.
Disposal of Product: Dispose by incineration at a licensed chemical waste disposal facility following local, regional, and national regulations.
Disposal of Contaminated Packaging: Empty containers retain residues and should be treated as hazardous. Dispose of as unused material.
Environmental Precautions: Do not allow product or residues to enter drains or water courses.
UN Number: Not assigned
Proper Shipping Name: Not regulated under most national/international transport guidelines. For bulk or commercial shipments, consult relevant authority.
Transport Hazard Class: Not classified
Packing Group: Not assigned
Environmental Hazards: Dangerous to aquatic life; should not be transported with foodstuffs or animal feeds.
Special Precautions: Secure containers and prevent leakage. Carry copy of MSDS during shipment.
Safety, Health and Environmental Regulations: Not specifically listed by OSHA, TSCA, REACH, or other major regulatory lists as of latest update.
Inventory Status: Check compliance with country-specific chemical inventories.
Labeling Requirements: Hazard statements and risk phrases required on labels in accordance with GHS.
Other Regulations: Observe all national and local environmental protection regulations. Consult workplace H&S authority for further guidance on handling and risk assessment.
