Material Safety Data Sheet (MSDS) for 1-Isopropyl-4-Aminopiperidine

1. Identification

Product Name: 1-Isopropyl-4-Aminopiperidine
Synonyms: 4-Amino-1-isopropylpiperidine
CAS Number: Not regularly documented in public chemical catalogs
Recommended Use: Research and industrial chemical applications
Supplier: Laboratory, chemical vendor, or in-house formulation
Emergency Contact: Laboratory supervisor or chemical safety officer
Telephone Number for Emergency: Listed on institution-specific emergency sheet or SDS

2. Hazard Identification

Classification: Flammable liquid, acute toxicity (oral and dermal), skin and eye irritant
Hazard Statements: Risk of respiratory and skin irritation, eye damage, toxicity if inhaled or ingested
Pictograms: Flame, exclamation mark, skull and crossbones
Signal Word: Danger
Precautionary Statements: Wear protective gloves, keep away from ignition, avoid contact, handle in fume hood
Emergency Overview: Clear or slightly yellow liquid, strong ammonia-like odor, may irritate mucous membranes
Potential Health Effects: Burns, headache, nausea, coughing, dizziness, shortness of breath on exposure

3. Composition / Information on Ingredients

Chemical Name: 1-Isopropyl-4-Aminopiperidine
Formula: C8H18N2
Concentration: Typically over 95% per batch for research chemical
Impurities: Minimal, but may include residual solvents or byproducts from synthesis such as isopropanol or piperidine traces
Other Ingredients: None typically present in pure material

4. First Aid Measures

Inhalation: Move to fresh air, administer oxygen if breathing difficult, seek immediate medical help
Skin Contact: Remove contaminated clothing, flush thoroughly with water, use mild soap, medical attention for burns
Eye Contact: Rinse cautiously with clean water for 15 minutes, remove contact lenses, seek immediate medical care
Ingestion: Rinse mouth, do not induce vomiting, seek urgent medical advice, provide SDS to responders
General Advice: Keep patient warm and at rest, note symptoms for healthcare staff, always have eyewash and shower access in labs

5. Fire-Fighting Measures

Extinguishing Media: Use carbon dioxide, dry chemical, or foam, water spray for larger fires
Special Hazards: Emits toxic fumes including nitrogen oxides and carbon monoxide in fire
Protective Equipment: Wear self-contained breathing apparatus, fire-resistant clothing, gloves
Advice for Firefighters: Approach from upwind, prevent runoff into drains
Combustion Products: Carbon oxides, nitrogen oxides, hydrogen cyanide possible in oxygen-starved conditions

6. Accidental Release Measures

Personal Precautions: Use gloves, goggles, lab coat, respirator in poorly ventilated areas
Environment Precautions: Prevent chemical from environmental discharge, use spill barriers, notify authorities if large spill enters water systems
Cleanup Methods: Contain with inert absorbents, sweep into container for disposal, ventilate area well
Decontamination: Wash surfaces with soapy water, dispose of cleaning materials appropriately

7. Handling and Storage

Handling: Use in fume hoods, wear protection, avoid inhalation or direct contact, keep container sealed when not in use, avoid sources of ignition
Storage: Store in cool, dry, well-ventilated space, away from incompatible materials such as oxidants or acids, keep tightly closed in original or compatible secondary container
Special Sensitivities: Avoid extreme heat, moisture, and direct sunlight; label containers

8. Exposure Controls and Personal Protection

Control Parameters: No established OSHA/ACGIH limits; treat as hazardous chemical
Engineering Controls: Chemical fume hood, eyewash stations, local exhaust
Personal Protective Equipment (PPE): Chemical-resistant gloves (nitrile), goggles or face shield, lab coat, appropriate respirator if airborne risk exists
Hygiene Measures: Wash hands after handling, remove contaminated clothing promptly, avoid eating or drinking in chemical areas

9. Physical and Chemical Properties

Appearance: Clear or pale yellow liquid
Odor: Ammonia / amine odor noticeable on opening
Melting Point/Range: Undocumented due to lack of reference standard
Boiling Point/Range: Estimated 180-200°C
Solubility: Miscible in water and some organic solvents
Flash Point: Estimated 70–90°C
Vapor Pressure: Not assessed, but expected to be moderate
Relative Density: Not precisely established, ~0.9 (est.)
pH: Alkaline in solution
Other Properties: Flammable, corrosive properties possible on prolonged contact

10. Stability and Reactivity

Chemical Stability: Stable under recommended storage, decomposes at high temperature
Reactivity: Reacts with acids, oxidizing agents
Hazardous Reactions: May form flammable gases with acid or strong oxidizer
Decomposition Products: Ammonia, nitrogen oxides, hydrocarbon fragments
Storage Incompatibility: Avoid oxidizers, acids, chlorinated compounds

11. Toxicological Information

Acute Toxicity: Harmful if swallowed, inhaled, or absorbed through skin
Skin/Eye Sensitization: Causes irritation, risk of burns
Inhalation Effects: Dizziness, nausea, headache, respiratory irritation
Chronic Effects: Repeated exposure may cause dermatitis, liver or kidney issues
Carcinogenicity: Not classified or tested, unknown long-term effects
Mutagenicity: Insufficient data
LD50/LC50: Not measured, expect ranges similar to aliphatic amines

12. Ecological Information

Toxicity to Aquatic Life: Potentially hazardous, do not allow large quantities to enter waterways
Persistence/Degradability: Slow natural breakdown, may persist if released
Bioaccumulation: Unknown, should be minimized due to amine group presence
Mobility: Soluble in water, moves rapidly in moist soil
Other Effects: Can cause pH shifts in water, may disrupt ecosystem balance

13. Disposal Considerations

Waste Disposal Method: Collect everything in sealed, labeled container, use licensed waste contractor
Contaminated Packaging: Rinse and destroy in line with local law
Precautions for Disposal: Avoid drain disposal, incinerate in chemical waste facility
Disposal Regulations: Observe all local, state, and national statutes; consult environmental agency

14. Transport Information

UN Number: Not specifically assigned, treat as hazardous chemical
ADR/RID/IMDG/IATA Classification: Flammable liquid, toxic
Proper Shipping Name: 1-Isopropyl-4-Aminopiperidine or generic hazardous amine
Packing Group: III (suggested due to toxicity)
Hazard Label: Flammable liquid, toxic
Special Precautions: Secure during transit, transport with MSDS and emergency contact sheets

15. Regulatory Information

Labeling: Comply with OSHA, WHMIS, and CLP/GHS; mention specific hazards
Inventory Status: Not commonly listed on TSCA, EINECS, or REACH
Safety Assessment: Use only for R&D with completed risk analysis
Restrictions: Not for consumer use, limit access to trained laboratory staff
Other Regulatory Data: Local authority access and permits as required for fresh amines and hazardous organic bases