Product Name: 1-Ethylpiperazine
CAS Number: 5308-25-8
Synonyms: N-Ethylpiperazine; 1-Ethyl-1,4-diazacyclohexane
Recommended Use: Chemical intermediate, pharmaceutical manufacture, organic synthesis
Supplier Information: Chemical distributor or manufacturer, including address, phone number, and emergency contact which should be up-to-date for immediate queries in case of misuse or spill
Emergency Telephone: Should be manned 24/7 for rapid safety support.
GHS Classification: Flammable liquid (Category 3), Acute toxicity (Oral, Category 4), Skin corrosion/irritation (Category 2), Serious eye damage/eye irritation (Category 2A)
GHS Label Elements: Signal word “Warning”, hazard pictograms for corrosion, exclamation mark, and flammable symbol
Hazard Statements: Causes skin irritation, causes serious eye irritation, harmful if swallowed, flammable liquid and vapor
Precautionary Statements: Keep away from heat, sparks, open flames, and hot surfaces. Wear protective gloves, eye, and face protection. Avoid breathing vapor, wash thoroughly after handling, and use only in well-ventilated areas
Potential Health Effects: Inhalation or contact may lead to burning sensation, coughing, redness, and irritation; severe exposure could impact respiratory and central nervous systems.
Substance: Pure 1-Ethylpiperazine
Chemical Formula: C6H14N2
Molecular Weight: 114.19 g/mol
Concentration: 98%–100% pure
Impurities: Trace organic solvents or water possible, check certificate of analysis for batch specifics
Inhalation Exposure Limits: No established long-term exposure limit or short-term exposure limit by OSHA, ACGIH, or NIOSH; general safe handling principles should apply.
Inhalation: Remove the person away from exposure into fresh air immediately, seeking medical attention if irritation, coughing, or breathing difficulties occur.
Skin Contact: Flush skin with plenty of water while removing contaminated clothing. Seek medical help if irritation continues or blisters develop.
Eye Contact: Rinse the eyes with water for at least 15 minutes, holding eyelids wide open. Remove contact lenses and continue rinsing. Always get medical attention after an eye splash.
Ingestion: Do not induce vomiting. Rinse mouth with water and seek urgent medical advice. Never give anything by mouth if the person is unconscious.
Notes to Physician: Standard handling for chemical exposures; treat symptomatically.
Suitable Extinguishing Media: Use foam, dry chemical powder, or carbon dioxide; water spray can cool surfaces, but direct streams may spread the fire.
Specific Hazards: Vapors heavier than air, may travel to ignition sources and flash back; emits toxic fumes (nitrogen oxides, carbon oxides) under fire conditions.
Protective Equipment for Firefighters: Wear self-contained breathing apparatus and full protective clothing to avoid chemical exposure.
Advice for Firefighters: Move containers from fire area if safe to do so. Cool unopened containers with water mist to prevent overheating and explosion.
Explosion Data: Vapor forms explosive mixtures with air; risk increases with concentration, temperature, and poor ventilation.
Personal Precautions: Wear protective equipment including gloves, goggles, and chemical-resistant clothing; avoid inhale or direct contact. Evacuate unnecessary personnel.
Environmental Precautions: Prevent product from entering drains, surface water, and soil to reduce local contamination. Notify proper authorities in case of unavoidable spillage into the environment.
Cleanup Methods: Absorb spill with inert absorbent material (sand, earth, vermiculite), then collect in proper chemical waste container for disposal. Ventilate affected area and wash spill zone with water after material removal.
Decontamination: Dispose of water and used absorbent material according to chemical waste protocols, ensuring proper labeling and handling for hazardous waste streams.
Handling: Work in well-ventilated areas to minimize vapor buildup. Avoid skin and eye contact, do not breathe vapors. Wear appropriate personal protective equipment. Keep away from incompatible chemicals such as strong acids and oxidizers. Use with grounding and bonding to prevent static discharge. Practice good industrial hygiene—wash hands after handling.
Storage: Store in tightly closed containers, away from direct sunlight, sparks, or open flames in a temperature-controlled, appropriately ventilated area. Separate from food, drink, and animal feed material. Add secondary containment to reduce risk of leakage or accidental release.
Engineering Controls: Use process enclosures, local exhaust ventilation, or other engineering controls to maintain airborne levels below recommended exposure limits. Install proper eye wash stations and safety showers near handling zones.
Personal Protective Equipment: Chemical splash goggles and face shield for eye protection; impermeable gloves for hand protection; long-sleeved lab coat or apron; suitable respiratory protection if ventilation proves unsatisfactory
Workplace Hygiene: Do not eat, drink, or smoke while handling chemical. Wash hands and face after use.
Physical State: Clear to pale yellow liquid
Odor: Amine-like, sharp
pH: Basic aqueous solution
Boiling Point: 164–166°C (approximate at 760 mm Hg)
Melting Point: -38°C (approximate)
Flash Point: 54°C (closed cup)
Explosion Limits: Lower 1.6%, upper 10.7% (v/v)
Vapor Pressure: 3 mmHg at 25°C
Solubility: Miscible with water and common organic solvents
Partition Coefficient: log Kow around 0.26
Density: 0.86 g/cm³ at 20°C
Viscosity: Low (similar to other light amines)
Evaporation Rate: Moderate, depending on ventilation and surface area.
Chemical Stability: Stable under recommended storage conditions; instability may arise from extreme temperatures or extended exposure to air
Conditions to Avoid: Exposure to heat, sparks, flame, incompatible chemicals such as strong acids, oxidizers, and acid chlorides
Incompatible Materials: Strong oxidizers, acids, oxidizing agents, acid anhydrides
Hazardous Decomposition Products: Nitrogen oxides, carbon monoxide, carbon dioxide upon combustion or decomposition
Polymerization: Does not polymerize under normal processing conditions.
Acute Toxicity: Oral LD50 (rat): estimated range 900–1500 mg/kg; inhalation hazard data limited but expected to be moderate
Skin Corrosion/Irritation: Causes redness and irritation on contact. Severe or prolonged exposure can cause burns or dermatitis.
Serious Eye Damage/Irritation: Causes significant eye irritation, watering, redness; may risk injury if not flushed quickly.
Respiratory Sensitization: Irritating to respiratory tract; cough, burning, and in rare cases dizziness or headache with high exposure.
Chronic Effects: Prolonged or repeated exposure could aggravate pre-existing skin or respiratory disorders.
Carcinogenicity, Mutagenicity, Reproductive Toxicity: No classifications by IARC, ACGIH, NTP, or OSHA at present.
Other Information: Adequate ventilation and protective measures reduce risk for most users handling infrequent or moderate quantities.
Aquatic Toxicity: Freshwater fish and invertebrates show moderate acute toxicity; LC50 (96 hr, fish): estimate >100 mg/L
Persistence and Degradability: Readily biodegradable under aerobic conditions, with most breakdown occurring in weeks
Bioaccumulation: Low bioconcentration potential based on measured log Kow values
Mobility in Soil: High mobility, given solubility and low partition coefficient
Other Adverse Effects: Large releases increase risk of local water or soil contamination; environmental release controls are important for responsible handling.
Waste Disposal Methods: Incineration recommended at approved chemical disposal sites. Chemical must never be dumped to surface water or sewage. Follow federal, state, and local regulations for handling of hazardous organic amines.
Container Disposal: Empty containers require triple-rinsing or puncturing to prevent reuse; label remains hazardous until cleaning is confirmed. Final disposal at licensed hazardous waste facility.
UN Number: UN2734
Proper Shipping Name: Ethylpiperazine
Transport Hazard Class: 3 (Flammable Liquid)
Packing Group: III
Marine Pollutant: Not classified as marine pollutant under IMDG Code, but environmental precautions still relevant
Special Precautions: Ensure closures are tight and containers are upright. Shipping papers should include emergency contact and hazard labels.
US TSCA: Listed on the US Toxic Substances Control Act Inventory
OSHA: Considered hazardous; standard workplace chemical safety standards apply
SARA Title III: Not listed as an extremely hazardous substance; reporting required for large quantities
REACH (EU): Included in REACH inventory; use restrictions may apply depending on registration status
Other Information: State and local regulations for storage, handling, and disposal may differ; review site-specific legal compliance.
