Product Name: 1-Cbz-Piperazine
Chemical Name: 1-(Benzyloxycarbonyl)piperazine
CAS Number: 147083-12-9
Synonyms: N-Cbz-piperazine
Recommended Use: Intermediate for pharmaceuticals and organic synthesis
Supplier: Name, address, contact info, emergency contact number of the manufacturer or distributor
Emergency Phone Number: Provided by distributor, reachable 24/7
Classification: Not listed as hazardous under GHS classification, may cause respiratory or skin irritation in powder form
Signal Word: Warning
Hazard Statements: May form combustible dust concentrations in air; can cause mild irritation to skin and eyes; inhalation of powder may result in coughing or sore throat
Pictograms: Exclamation mark if irritation threshold is met
Precautionary Statements: Avoid breathing dust; wash hands after handling; use in well-ventilated areas; wear personal protective equipment
Routes of Exposure: Inhalation, skin, eye contact
Chemical Name: 1-(Benzyloxycarbonyl)piperazine
CAS: 147083-12-9
Purity: Above 95% (standard technical grade)
Impurities: Trace organic synthesis byproducts under 1% (not classified as hazardous)
Other Components: Not applicable (single substance product)
General Advice: Move affected person away from exposure source. Seek medical attention if symptoms develop.
Inhalation: Remove to fresh air. Monitor breathing. Seek medical help if cough or discomfort persists.
Skin Contact: Remove contaminated clothing. Wash skin thoroughly with soap and water. Seek medical advice for irritation.
Eye Contact: Rinse cautiously with water for minutes, lifting eyelids occasionally. Remove contact lenses if present.
Ingestion: Rinse mouth. Do not induce vomiting. Monitor for nausea or abdominal pain. Get medical assistance.
Suitable Extinguishing Media: Water spray, dry chemical, foam, or carbon dioxide
Unsuitable Media: Strong streams of water may spread powder or dust
Specific Hazards: Combustion may generate hazardous gases such as carbon monoxide, carbon dioxide, nitrogen oxides
Protective Equipment: Firefighters should use self-contained breathing apparatus and full protective gear
Special Procedures: Cool containers with water if exposed to flames. Control run-off to prevent environmental impact.
Personal Precautions: Wear chemical-resistant gloves, safety goggles, and lab coat. Avoid contact with skin, eyes, and clothing. Avoid inhaling dust.
Environmental Precautions: Prevent run-off from entering drains, sewers, or open water. Collect spills immediately.
Methods for Clean-Up: Sweep or scoop up spillage, use non-sparking tools. Place material in closed container for disposal. Ventilate area.
Other Considerations: Dispose of waste according to local regulations. Wash spill site after material removal.
Precautions for Safe Handling: Use appropriate ventilation. Avoid dust formation. Minimize prolonged or repeated contact. Do not eat, drink, or smoke in work area.
Conditions for Safe Storage: Store in tightly closed, properly labeled containers away from direct sunlight, heat sources, and incompatible materials such as strong acids or oxidizers. Keep storage area cool, dry, and well-ventilated.
Specific End Uses: Only for research, laboratory, or industrial use as designated on the label.
Control Parameters: No occupational exposure limits set by OSHA, ACGIH, or NIOSH
Engineering Controls: Handle in chemical fume hood if possible. Use local exhaust ventilation to reduce airborne concentration.
Personal Protective Equipment:
Appearance: White to off-white solid, crystalline powder
Odor: Odorless or faint organic scent
pH: Not applicable (solid form)
Melting Point: 58–62 °C
Boiling Point: Decomposition before boiling
Flash Point: Data not available
Evaporation Rate: Not determined
Flammability: Dust may be combustible in air
Vapor Pressure: Negligible at room temperature
Specific Gravity: Not established
Solubility: Slightly soluble in water; soluble in organic solvents like methanol or DMSO
Partition Coefficient: Data not available
Viscosity: Not applicable
Other Information: Tends to form dust if handled improperly
Chemical Stability: Stable at room temperature in closed containers under recommended storage conditions
Reactivity: Not reactive under standard laboratory conditions
Conditions to Avoid: Excessive heat, open flame, source of ignition, strong oxidizing agents
Incompatible Materials: Strong acids, oxidizers, strong bases may cause reaction
Hazardous Decomposition Products: Combustion releases carbon monoxide, carbon dioxide, nitrogen oxides
Polymerization: Not expected to occur
Acute Toxicity: Data for LD50 or LC50 not available; similar compounds known to have low oral, dermal toxicity
Skin Corrosion/Irritation: May cause mild irritation after prolonged contact
Serious Eye Damage/Irritation: May cause temporary discomfort or redness
Respiratory Sensitization: No data; dust may irritate airways
Germ Cell Mutagenicity: Not classified as mutagenic by available studies
Carcinogenicity: Not listed as a carcinogen under IARC, NTP, ACGIH, or OSHA
Reproductive Toxicity: No evidence found in available animal studies
Specific Target Organ Toxicity: Not expected at small scale lab exposure
Aspiration Hazard: No known hazard
Ecotoxicity: No studies specifically on this compound; structural analogs show low aquatic toxicity at lab concentrations
Persistence and Degradability: Likely to degrade slowly in environment; not persistent in typical wastewater conditions
Bioaccumulative Potential: Low potential based on molecular structure
Mobility in Soil: Not expected to migrate rapidly in soils
Other Adverse Effects: Not considered hazardous to ozone layer or other environmental compartments at typical research scale
Waste Treatment Methods: Collect and place in labeled chemical waste container
Disposal of Product: Burn in a chemical incinerator equipped with afterburner and scrubber if allowed by local regulations
Disposal of Packaging: Dispose of empty containers in accordance with local, regional, and national regulations. Avoid discharge into the environment.
Contaminated Packaging: Triple rinse and offer for recycling or reconditioning if feasible
Special Precautions: Consult waste disposal company for guidance under hazardous chemical waste rules
UN Number: Not regulated as a dangerous good for ground, air, or maritime transport
Transport Hazard Class: Not classified
Packing Group: Not assigned
Marine Pollutant: Not classified
Proper Shipping Name: 1-(Benzyloxycarbonyl)piperazine or laboratory chemical
Transport Precautions: Securely seal packaging. Keep away from incompatible materials. Follow standard chemical transport guidelines.
USA OSHA Status: Considered non-hazardous under OSHA Hazard Communication Standard
TSCA Status: Exempt or listed if imported/manufactured in the US
SARA Title III Sections 311/312: Not a hazardous chemical
California Proposition 65: Not listed
Canadian WHMIS Classification: Not subject to WHMIS requirements; check local jurisdiction
Europe REACH: Not registered under Annex XVII; safety data available to downstream users
Other International Inventories: Confirmed or notified to main regulatory agencies in South Korea, Japan, Australia
