Product Name: 1-Bis(4-Fluorophenyl)Methylpiperazine
Chemical Formula: C17H18F2N2
Synonyms: 1-[(4-Fluorophenyl)(4-fluorophenyl)methyl]piperazine
Manufacturer: Chemical supplier or laboratory distributor information required
Recommended Uses: Research applications
Contact Information: Emergency phone number for local regulatory body or poison control center; address for material provider
Classification: Acute toxicity (oral, dermal, inhalation); skin and eye irritant; suspected reproductive toxicant
Signal Word: Warning
Hazard Statements: Harmful if swallowed, causes skin irritation, causes serious eye irritation, may cause respiratory irritation
Precautionary Statements: Avoid contact with skin, eyes, and clothing; wear protective equipment; avoid inhaling dust or vapors; wash hands thoroughly after handling; do not eat, drink, or smoke during use
Potential Health Effects: Shortness of breath, skin redness, itching, burning of eyes, abdominal pain, nausea, central nervous system depression
Chemical Name: 1-[Bis(4-Fluorophenyl)Methyl]Piperazine
CAS Number: 66490-71-7
Concentration: 100% (pure substance)
Impurities and Stabilizing Additives: No significant impurities expected if handled according to supplier recommendations. Minor residues on equipment surfaces may occur with frequent transfer or weighing.
Inhalation: Move person outdoors to fresh air. If breathing seems difficult or stops, use artificial respiration and seek immediate medical attention. Monitor for wheezing, coughing, or dizziness.
Skin Contact: Remove any contaminated clothing. Wash skin thoroughly under running water using non-abrasive soap. Watch for irritation or blistering. Seek medical attention for persistent discomfort.
Eye Contact: Rinse eyes with plenty of cool running water for several minutes, lifting eyelids regularly. Remove contact lenses if present and easy to do. Seek ophthalmological advice if irritation remains.
Ingestion: Rinse mouth thoroughly, drink water as tolerated. Do not induce vomiting unless directed by medical personnel. Never give anything by mouth to an unconscious person. Contact a physician or poison center immediately.
Note for Emergency Providers: Symptomatic treatment and supportive measures; monitor respiratory, cardiovascular, and neurological status.
Suitable Extinguishing Media: Dry chemical powder, carbon dioxide, foam, or water spray
Specific Hazards from Combustion: Releases toxic fumes including hydrogen fluoride, nitrogen oxides, and carbon oxides when burning.
Special Protective Equipment: Firefighters should wear self-contained breathing apparatus and chemical protective clothing.
Precautions for Firefighters: Stay away from smoke; contain run-off to avoid environmental contamination. Cool exposed containers and surrounding area with water mist.
Personal Precautions: Evacuate spill area. Use personal protective equipment including gloves, goggles, and a lab coat. Prevent dust formation and avoid inhalation.
Environmental Precautions: Stop spillage from entering drains, surface water, or soil. Use sand, earth, or other inert material to contain liquid or powder leaks.
Clean-Up Methods: Sweep up material carefully, avoiding dust clouds. Place waste in clearly labeled chemical waste container. Clean contaminated area with water and mild detergent. Ensure adequate ventilation in the cleanup area.
Emergency Procedures: Restrict access to affected area until clean-up is complete. Consult local hazardous waste guidelines.
Handling: Work only in well-ventilated areas or fume hoods. Use gloves and goggles to avoid exposure. Handle containers gently to prevent breakage. Avoid release of dust and do not breathe vapors.
Hygiene Practices: Wash hands and forearms thoroughly after working with this compound. Remove contaminated clothing before leaving lab environment.
Storage Conditions: Keep container tightly closed in a cool, dry, and well-ventilated area. Store away from incompatible chemicals including oxidizers, strong acids, or bases. Minimize exposure to direct sunlight and moisture.
Packing: Use airtight, chemical-resistant containers with clear hazard labeling. Secure storage away from food, beverages, and animal feed.
Exposure Limits: No established occupational exposure limits for this compound; minimize all exposure.
Engineering Controls: Employ fume hoods or local exhaust to capture vapors or dust at point of release.
Personal Protective Equipment: Chemical-resistant gloves (nitrile or neoprene), lab coat, safety goggles, and, if risk of inhalation, a particulate respirator (P3 or N95).
Environmental Controls: Use spill containment trays and glovebox handling for sensitive activities. Dispose of contaminated materials in marked chemical waste bins.
Physical State: Solid (powder or crystalline, depending on preparation)
Color: White to off-white
Odor: Faint aromatic odor, not easily detected at low concentrations
Molecular Weight: 286.34 g/mol
Melting Point: Information limited; estimated near 155-165°C
Boiling Point: Not readily available; likely decomposes prior to boiling
Solubility: Slightly soluble in water; soluble in organic solvents such as ethanol, chloroform, and DMSO
Vapor Pressure: Very low at room temperature
pH (solution): Data not available
Partition Coefficient: Log P expected in the 2–4 range (moderate lipophilicity)
Chemical Stability: Stable under recommended handling and storage conditions; sensitive to high temperatures and strong acids or bases
Hazardous Reactions: May react with oxidizing agents, strong acids, or bases
Decomposition Products: May include toxic gases such as hydrogen fluoride, carbon monoxide, carbon dioxide, nitrogen oxides upon thermal decomposition
Conditions to Avoid: Moisture, sunlight, elevated temperatures, open flame, and incompatible chemicals
Acute Effects: Harmful if swallowed, inhaled, or absorbed through skin; symptoms may include headache, dizziness, nausea, respiratory and central nervous system effects
Chronic Effects: Repeated or prolonged exposure might lead to organ damage or reproductive toxicity. Data is currently scarce; effects should be considered potentially cumulative.
Routes of Exposure: Skin contact, eye contact, inhalation, ingestion
Sensitization: Potential for skin and respiratory sensitization observed in related piperazine compounds
Carcinogenicity: Not classified as carcinogen by IARC, NTP, or OSHA. Long-term data is limited.
Mutagenicity: No sufficient data; handle as potential mutagen.
Reproductive Toxicity: Some piperazine derivatives associated with developmental risks; take extra precautions for pregnant people.
Aquatic Toxicity: Not thoroughly evaluated; fluorinated aromatic chemicals often persist and can accumulate in aquatic organisms
Persistence and Degradability: Expected to degrade slowly; fluorine atoms resist typical microbial and photolytic breakdown
Bioaccumulation: Moderate potential for bioaccumulation in aquatic systems, particularly in benthic organisms
Mobility in Soil: Likely to bind to organic-rich soils, but may migrate in water systems
Other Adverse Effects: Toxic to aquatic life with long lasting effects; prevent spillage to the environment
Waste Treatment Methods: Collect solid or liquid waste in labeled hazardous waste containers. Never pour down the drain. Use a licensed chemical disposal contractor familiar with regulated organic chemicals.
Disposal of Contaminated Packaging: Rinse well, then dispose of containers as hazardous waste according to municipal or national regulations.
Special Precautions: Do not reuse empty containers. Avoid environmental release by incinerating wastes in approved facilities. Comply with local and federal waste laws.
UN Number: Not allocated; transport as chemical, n.o.s. if required
Proper Shipping Name: Laboratory chemical, organic solid, hazardous
Hazard Class: 6.1 (Toxic substances) for many jurisdictions
Packing Group: III (if classified as a low-toxicity solid); verify local regulations
Environmental Hazards: Substance may present hazard to aquatic environment during transit
Special Provisions: Secure packaging, clear hazard labeling, restrict movement in passenger compartments; emergency contact information on transport documents.
US TSCA Status: Check with chemical supplier for specific registry status
European Regulations: May require REACH registration; consult ECHA for updates
Canada DSL/NDSL: Supplier confirmation necessary for Canadian use
Labeling Requirements: Use GHS symbols and standardized hazard statements
Restrictions on Use: For research or laboratory applications only; not for food, drug, or household purposes
SARA/Title III Hazards: Not listed, but treat as toxic for reporting thresholds
Other Regulatory Status: Ensure compliance with all applicable federal, state, and local workplace and environmental regulations.
