Product Name: 1-Benzoylpiperazine Hydrochloride
Synonyms: N-Benzoylpiperazine Hydrochloride
Chemical Family: Piperazine derivatives
Molecular Formula: C11H14N2O·HCl
Molecular Weight: 242.7 g/mol
Chemical Abstracts Service (CAS) Number: 5321-48-2
Recommended Use: Laboratory chemical, chemical synthesis
Supplier Details: Contact information of the manufacturer or distributor, including emergency telephone number
Emergency Overview: White or off-white crystalline powder with no distinct odor
GHS Classification: Acute toxicity (Oral) Category 4; Eye irritation Category 2A; Skin irritation Category 2
Signal Word: Warning
Hazard Statements: Harmful if swallowed; Causes skin and eye irritation
Pictograms: Exclamation mark
Precautionary Statements: Avoid breathing dust; Wash thoroughly after handling; Wear protective gloves, clothing, and eye protection; Do not eat, drink, or smoke when using this product
Potential Health Effects: Eye contact causes redness and irritation; skin exposure leads to itching and discomfort; ingestion can produce nausea, headache, drowsiness
Chronic Effects: No long-term studies identified, but repeated contact may intensify irritation
Environmental Hazards: Toxicity to aquatic life not fully evaluated, precaution suggested for spills to prevent runoff
Chemical Name: 1-Benzoylpiperazine Hydrochloride
CAS Number: 5321-48-2
Concentration: ≥98% by weight
Impurities: Trace amounts of unreacted starting materials possible
Additives: None known
Formulation: Solid, no known diluents
Eye Contact: Rinse with plenty of water for at least 15 minutes, lifting eyelids occasionally; remove contact lenses if present and easy
Skin Contact: Wash area with soap and water, remove contaminated clothing and shoes
Inhalation: Remove to fresh air; keep person warm and at rest; seek medical attention if symptoms occur
Ingestion: Rinse mouth; get medical help immediately; do not induce vomiting unless instructed by medical personnel
Most Important Symptoms and Effects: Burning eyes, respiratory discomfort, skin redness
Notes to Physician: Symptomatic and supportive care, monitor for signs of systemic toxicity
Flammability: Product does not burn easily, but dust can form explosive mixtures in air
Suitable Extinguishing Media: Water spray, alcohol-resistant foam, dry chemical, carbon dioxide
Unsuitable Extinguishing Media: Avoid direct water stream as it may spread the fire or disperse powder
Specific Hazards in Fire: Hydrogen chloride, nitrogen oxides, carbon monoxide can be released upon thermal decomposition
Protective Equipment: Firefighters wear self-contained breathing apparatus, full protective gear
Special Precautions: Use water spray to cool containers near fire, prevent extinguishing runoff from entering drains or watercourses
Personal Precautions: Minimize dust creation; ensure adequate ventilation; wear personal protective equipment including gloves, goggles, and dust mask
Environmental Precautions: Prevent product from entering drains, waterways or soil; contain spillage with non-combustible absorbent material
Spill Cleanup Methods: Sweep up without generating dust; place in suitable, labeled container for disposal; ventilate area
Decontamination: Wash area with copious amounts of water; avoid direct contact with substance during cleanup
Safe Handling: Handle in a chemical fume hood to reduce airborne exposure; avoid formation of dust; avoid contact with eyes, skin, and clothing
Hygiene Practices: Wash hands and face before breaks and after handling; do not eat, drink, or smoke in work areas
Storage Conditions: Store tightly closed in original container; keep in a cool, dry, and well-ventilated area away from sunlight
Incompatible Materials: Strong oxidizing agents, acids, bases
Specific Requirements: Keep separate from food and feedstuffs; avoid rough handling and impact to container
Occupational Exposure Limits: No established limits; minimize workplace exposure using engineering controls
Engineering Controls: Use local exhaust ventilation and process enclosure where dust can be generated
Personal Protective Equipment: Certified gloves (nitrile or neoprene), lab coat, chemical safety goggles, dust mask or NIOSH-certified respirator for high concentrations
Hand Protection: Chemical-resistant gloves recommended
Eye Protection: Safety goggles or face shield
Skin Protection: Impervious clothing, closed footwear
Appearance: White or off-white powder or crystalline solid
Odor: Odorless
pH (1% solution): 3.5–4.5
Melting Point: 164–169°C
Boiling Point: Decomposes
Solubility: Soluble in water, slightly soluble in alcohol
Flash Point: Not applicable
Explosive Limits: Data not available
Vapor Pressure: Negligible at room temperature
Density: Data not available; expected to be around 1.15–1.25 g/cm³
Partition Coefficient (n-octanol/water): Not determined
Chemical Stability: Stable under recommended storage conditions
Reactivity: Inert under normal conditions
Hazardous Reactions: Reacts with strong oxidizers; may release fumes of hydrochloric acid and nitrogen oxides if decomposed by heat
Conditions to Avoid: Excessive heat, moisture, direct sunlight, strong acids or bases
Hazardous Decomposition Products: Hydrogen chloride, carbon monoxide, carbon dioxide, nitrogen oxides
Likely Routes of Exposure: Inhalation, ingestion, skin and eye contact
Acute Toxicity: Harmful if swallowed; estimated LD50 in laboratory animals is in the range of several hundred mg/kg
Skin Contact: May cause local redness, itching, discomfort; not expected to cause serious dermal injury
Eye Contact: May cause irritation, redness, watering
Inhalation: Nausea, dizziness, headache if significant dust is inhaled
Chronic Toxicity: Evidence of chronic impact not established; long-term exposure not recommended
Carcinogenicity/Mutagenicity: Not classified as a carcinogen; mutagenicity not thoroughly investigated
Other Data: Central nervous system effects possible with large exposures
Ecotoxicity: Data unavailable; caution suggested, avoid release to environment
Persistence and Degradability: Not rapidly biodegradable; persists in soil and water
Bioaccumulation: Potential for bioaccumulation not evaluated
Mobility in Soil: Moderate mobility expected
Other Adverse Effects: No data on ozone layer depletion or other specific hazards
Waste Disposal Methods: Dispose in accordance with local, state, and federal regulations; incineration preferred for large quantities
Container Disposal: Triple rinse and offer for recycling or dispose as hazardous waste
Precautions: Do not allow product or waste to enter drains, watercourses, or soil; collect and seal in labeled, leak-proof containers for transport
UN Number: Not classified as dangerous for transport under UN regulations
Transport Hazard Classes: Not regulated
Packing Group: Not applicable
Transport Label: Non-hazardous chemical
Special Precautions for Transport: Protect from moisture and physical damage, ship in original packaging or equivalent sealed container
Environmental Hazards During Transport: Avoid spillage to reduce impact on aquatic and terrestrial life
International Inventories: Item not specifically listed on major chemical inventories
Label Requirements under GHS: Exclamation mark symbol, hazard statements for acute toxicity and irritation
EPA TSCA Status: Not listed
REACH: Registration and evaluation requirements apply in the EU for production/import above threshold amounts
Other Regulations: Not scheduled under controlled substances acts
Workplace Controls: Subject to standard chemical workplace health and safety regulations
Safety Assessment: Users ensure compliance with local and national chemical safety rules and industrial hygiene standards
