Product Name: 1-Acetyl-4-(4-Hydroxyphenyl)Piperazine
Chemical Formula: C12H16N2O2
CAS Number: 67848-71-9
Synonyms: N-Acetyl-4-(4-hydroxyphenyl)piperazine
Company Identification: Chemical Supplier’s Address, Emergency Hotline, Telephone
Recommended Use: Research, chemical synthesis, pharmaceutical intermediate
Restrictions on Use: Not intended for household use or food processing
Emergency Telephone: Manufacturer’s provided number
GHS Classification: Eye irritation (Category 2A), Skin irritation (Category 2), Acute toxicity (Oral) (Category 4)
Pictograms: Exclamation mark
Signal Word: Warning
Hazard Statements: May cause skin and eye irritation. Harmful if swallowed. Irritating to respiratory tract if dust is inhaled.
Precautionary Statements: Avoid breathing dust. Wash hands thoroughly after handling. Wear protective gloves and eye protection.
Potential Health Effects: Eyes—redness, watering, itching; Skin—dryness, cracking, redness; Inhalation—throat and nasal irritation, coughing; Ingestion—gastric discomfort, nausea.
Other Hazards: No classified mutagenicity or carcinogenicity based on available data.
Chemical Name: 1-Acetyl-4-(4-Hydroxyphenyl)Piperazine
Chemical Formula: C12H16N2O2
CAS Number: 67848-71-9
Concentration: >98% (main constituent)
Impurities: Minor unidentified process-related byproducts, less than 2% total
Additives: None
Inhalation: Remove person to fresh air, comfort in a half-upright position. Seek medical attention if symptoms persist.
Skin Contact: Wash thoroughly with soap and water for at least 15 minutes. Take off contaminated clothing. If irritation develops, get medical advice.
Eye Contact: Rinse immediately with plenty of water for at least 15 minutes, lifting upper and lower eyelids occasionally. Remove contact lenses if present. Seek medical care.
Ingestion: Rinse mouth thoroughly. Do not induce vomiting. Never attempt oral feeding in an unconscious individual. Seek immediate medical help.
Notes for Physician: Provide symptomatic and supportive care. Consider observation due to the chemical’s irritant potential.
Suitable Extinguishing Media: Water spray, dry chemical, foam, or carbon dioxide for small fires.
Unsuitable Extinguishing Media: Straight water streams may disperse powders.
Special Hazards: In case of fire, hazardous decomposition may produce carbon oxides, nitrogen oxides, and other toxic fumes.
Protective Equipment: Firefighters should wear full protective clothing, including self-contained breathing apparatus.
Fire Precautions: Avoid inhaling combustion gases. Prevent runoff from entering drains or surface waters.
Thermal Decomposition: Heat may induce breakdown, releasing hazardous gases.
Personal Precautions: Wear chemical-resistant gloves, safety goggles, lab coat, and suitable respiratory protection. Prevent contact with eyes, skin, and clothing.
Environmental Precautions: Prevent entry into waterways, drains, basements, or confined spaces. Notify authorities if material enters environment in significant quantities.
Cleanup Methods: Sweep up and place in suitable sealed container for proper disposal. Use an approved vacuum or wet method to minimize dust generation. Wash spill site thoroughly after material pickup.
Precautionary Statements: Avoid raising dust. Observe occupational hygiene controls during cleanup.
Handling: Use in well-ventilated workspaces. Avoid formation of dust and aerosol. Wear suitable protective clothing and equipment. Keep containers tightly closed. Avoid direct physical contact with the material.
Storage: Keep material in tightly sealed original container, away from heat, ignition sources, and incompatible chemicals. Store in a cool, dry, well-ventilated area. Segregate from food, drinks, and feedstuffs. Protect from light and moisture.
Incompatibilities: Strong oxidizers, strong acids and bases, reactive metal powders.
Specific End Uses: For laboratory research or industrial application; not for direct use in consumer products.
Engineering Controls: Ensure workplace air quality with local exhaust, fume hoods, or enclosures. Maintain eye-wash and safety shower in immediate work area.
Personal Protective Equipment: Eyes/Face—chemical safety goggles, face shield if risk of splashing; Hands—chemical-resistant gloves (nitrile or equivalent); Body—lab coat or coverall; Respiratory—approved dust mask or respirator if exposure to dust or fumes.
Occupational Exposure Limits: No established limits for this compound; handle as a potentially hazardous substance, using standard good laboratory practices.
Hygiene Practices: Avoid eating, drinking, and smoking in areas of use. Wash hands thoroughly before breaks and at end of shifts. Remove contaminated clothing and wash before reuse.
Environmental Exposure Controls: Collect all contaminated waste for disposal. Prevent uncontrolled release into water bodies or public sewers.
Appearance: White to off-white crystalline powder
Odor: Odorless or mild chemical odor
Odor Threshold: Not determined
pH: Neutral to slightly alkaline in water
Melting Point/Freezing Point: Approx. 102 – 106 °C
Boiling Point/Range: Decomposes above 250 °C
Flash Point: Not available
Evaporation Rate: Not applicable (solid material)
Flammability: Not highly flammable, combustible at elevated temperatures
Upper/Lower Flammability or Explosive Limits: Data not available
Vapor Pressure: Negligible at ambient temperature
Vapor Density: Not applicable
Specific Gravity: Approx. 1.23 g/cm³
Solubility in Water: Low to moderate; slightly soluble
Partition Coefficient (n-octanol/water): Not established
Auto-Ignition Temperature: Not data available
Decomposition Temperature: Above 250 °C
Viscosity: Not available (solid material)
Chemical Stability: Stable under ambient storage and handling conditions.
Reactivity: Not classified as reactive in normal use.
Conditions to Avoid: Contact with incompatible materials, sources of ignition, excessive heat, and prolonged sunlight.
Incompatible Materials: Strong oxidizers, strong acids and alkalis, reducing agents.
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, nitrogen oxides, and possibly toxic pyrolysis products.
Polymerization: No hazardous polymerization reported.
Acute Toxicity (Oral): Estimates suggest possible moderate toxicity; not fully characterized, handle with care.
Inhalation Exposure: Dust may irritate airways and mucous membranes.
Skin Contact: Possible mild to moderate irritation on prolonged or repeated contact.
Eye Contact: May induce irritation, redness, and discomfort.
Chronic Exposure: Data insufficient for chronic effects or organ toxicity. No evidence of carcinogenicity, mutagenicity, or reproductive toxicity based on limited studies.
Sensitization: Not identified as sensitizer; avoid extended skin contact.
Routes of Entry: Ingestion, inhalation, skin and eye contact.
Symptoms of Overexposure: Gastrointestinal distress, drowsiness, or headache reported with overexposure.
Medical Conditions Aggravated by Exposure: Individuals with existing skin, eye, or respiratory conditions may experience aggravated symptoms.
Aquatic Toxicity: No detailed data available; best practice assumes moderate toxicity to aquatic life due to similar organic compounds.
Persistence and Degradability: Possible moderate persistence; partial breakdown in environment; biodegradation rate not determined.
Bioaccumulative Potential: No significant bioaccumulation expected due to physical and chemical properties.
Soil Mobility: Expected low mobility in soil; potential for retention, slow leaching.
Other Adverse Effects: No significant ozone depletion, photochemical or global warming effects. All chemical waste should be minimized and contained.
Waste Treatment Methods: Collect all waste and disposals in sealed, labeled containers. Avoid release to drains or environment.
Disposal of Product: Treat as hazardous organic waste; send to licensed chemical disposal facility in accordance with local, regional, national, and international regulations.
Disposal of Contaminated Packaging: Triple rinse and render unusable before disposal as hazardous waste.
Special Precautions: Consult regulatory authorities for proper disposal. Never discharge directly into waterways.
UN Number: Not assigned for small-scale quantities.
UN Proper Shipping Name: Not regulated for land, air, or sea transport under current guidelines.
Transport Hazard Class: Not classified
Packing Group: Not assigned
Environmental Hazards: Not classified as dangerous for transport environment.
Special Transport Precautions: Secure packaging to prevent physical damage and leaks. Mark as laboratory chemical. Carry transport documentation.
International Chemicals Inventory Status: Not listed on most international chemical inventories; suitable only for research or industrial applications.
Safety, Health, and Environmental Regulations/Legislation Specific: Subject to control under chemical safety regulations (e.g., OSHA, TSCA, REACH). Confirm status for local jurisdiction.
Labeling Requirements: Label containers in accordance with OSHA Hazard Communication Standard or equivalent.
Other Regulations: Ensure training for those handling, label all containers, keep safety data sheet accessible.
