Product Name: 1,4-Dimethylpiperazine
Chemical Formula: C6H14N2
CAS Number: 106-58-1
Synonyms: N,N'-Dimethylpiperazine
Recommended Use: Intermediate in pharmaceutical, agrochemical, or chemical synthesis
Supplier: Chemical manufacturer or distributor details required
Emergency Contact Number: As provided by the chemical supplier
GHS Classification: Acute toxicity (oral, dermal, inhalation), skin and eye irritation, possible specific target organ toxicity
Signal Word: Warning
Hazard Statements: Harmful if swallowed, causes skin and serious eye irritation, may cause respiratory irritation
Pictograms: Exclamation mark
Precautionary Statements: Avoid breathing vapors, wear protective gloves and eye/face protection, wash hands thoroughly after handling, use only outdoors or in a well-ventilated area, if on skin wash with plenty of soap and water
Chemical Name: 1,4-Dimethylpiperazine
Concentration: Pure substance, 98-100%
Other Components: Trace impurities below 1%
Impurities Affecting Hazard: None known at significant concentration
Inhalation: Move to fresh air, keep person at rest, provide artificial respiration if not breathing, seek immediate medical attention
Skin Contact: Remove contaminated clothing, rinse skin with plenty of water for at least 15 minutes, call poison center or physician
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses if present, continue rinsing, seek medical advice
Ingestion: Rinse mouth with water, do not induce vomiting, give nothing by mouth if unconscious, call for medical assistance
Most Important Symptoms/Effects: Burning sensation, coughing, headache, redness or swelling of exposed skin and eyes
Suitable Extinguishing Media: Dry chemical, CO2, alcohol-resistant foam, or water spray
Unsuitable Extinguishing Media: Direct water jet if risk of contaminated runoff
Hazardous Combustion Products: Nitrogen oxides, carbon monoxide, carbon dioxide, irritating vapors
Firefighting Precautions: Use self-contained breathing apparatus, wear full protective clothing, keep containers cool by dousing with water
Special Hazards: Vapors heavier than air, risk of explosion in confined areas, toxic fumes possible during fire
Personal Precautions: Evacuate non-essential personnel, ventilate area, use personal protective equipment, avoid contact with skin and eyes, no smoking
Environmental Precautions: Prevent entry to drains, waterways, or soil, notify authorities of large spills
Containment Methods: Stop leak only if it can be done safely, contain spillage with absorbent material such as sand or inert ground material
Cleanup Procedures: Collect absorbed material in suitable containers for disposal, ventilate area, wash affected zones with water and detergent, dispose in accordance with local regulations
Safe Handling: Use only with adequate ventilation and proper containment systems, avoid breathing dust or vapor, avoid contact with skin, eyes, or clothing, wear suitable protective equipment, practice good hygiene
Storage Conditions: Store in tightly closed original containers, keep in a cool, dry, well-ventilated place away from sources of heat and ignition, keep separate from strong acids and oxidizers, store away from direct sunlight
Incompatible Materials: Strong oxidizing agents, acids and acid chlorides, may react with other reactive chemicals
Specific End Uses: Reserved for industrial, laboratory, or research contexts with controlled procedures
Occupational Exposure Limits: No established limits by OSHA, NIOSH, or ACGIH; minimize exposure
Engineering Controls: Use fume hoods or local exhaust ventilation, provide eyewash stations and safety showers
Personal Protection: Chemical splash goggles for eye protection, gloves resistant to chemicals such as nitrile, lab coat or coveralls, chemical-resistant boots, avoid ingestion or inhalation
Respiratory Protection: Use approved respirator if engineering controls are inadequate or airborne concentrations exceed recommended exposure levels
Appearance: Colorless to yellowish liquid
Odor: Amine-like, fishy odor
Odor Threshold: Not available
pH: Alkaline (aqueous solution)
Melting Point/Freezing Point: -6°C (21°F)
Boiling Point / Range: 140-142°C (284-288°F)
Flash Point: 32°C (90°F)
Evaporation Rate: Not determined
Flammability: Flammable liquid
Vapor Pressure: 3.5 mmHg at 20°C
Vapor Density: 3.4 (air = 1)
Relative Density: Approximately 0.85 g/cm³ at 20°C
Solubility in Water: Miscible
Partition Coefficient (n-octanol/water): Not available
Auto-ignition Temperature: 340°C (644°F)
Decomposition Temperature: Not established
Viscosity: Not specified
Chemical Stability: Stable under normal conditions and recommended storage practices
Reactivity: Highly reactive with strong oxidizing agents, can react with acids producing heat and hazardous vapors
Hazardous Reactions: Can form toxic gases in case of fire or reaction with incompatible chemicals
Decomposition Products: Nitrogen oxides, carbon oxides, volatile organic compounds
Conditions to Avoid: Excessive heat, open flames, static electricity, sources of ignition, contact with acids or oxidizers
Polymerization: Does not polymerize
Likely Routes of Exposure: Inhalation, skin and eye contact, ingestion
Acute Toxicity: Estimated oral LD50 in rats: 250 mg/kg, estimated dermal LD50 in rabbits: > 250 mg/kg
Skin Corrosion/Irritation: Causes moderate to severe irritation
Serious Eye Damage/Irritation: Causes severe eye irritation, risk of irreversible injury
Respiratory or Skin Sensitization: Not classified as sensitizer but may cause allergic reactions in some individuals
Carcinogenicity: Not listed by IARC, NTP, or OSHA as a carcinogen
Reproductive Toxicity: No conclusive human or animal data
Mutagenicity: No data indicating mutagenic potential
Target Organ Effects: Can affect respiratory system, central nervous system at high exposure
Ecotoxicity: Harmful to aquatic organisms in high concentrations, may cause long-term adverse effects in the aquatic environment
Persistence and Degradability: Readily biodegradable, but byproducts may persist
Bioaccumulation Potential: Unlikely to bioaccumulate due to low octanol-water partition coefficient
Soil Mobility: Moderate mobility, easily migrates with water
Other Adverse Effects: May contribute to chemical oxygen demand (COD) in waste streams
Disposal Methods: Incinerate in approved facility, follow all federal, state, and local environmental regulations
Waste Packaging: Contain residues and washings in approved chemical waste containers, do not dispose of in the environment
Sewage Disposal: Avoid discharge into drains or sewers
Contaminated Packaging: Empty containers should be rinsed and disposed of as hazardous waste
UN Number: UN 2734
Proper Shipping Name: Amines, liquid, corrosive, flammable, n.o.s. (contains 1,4-Dimethylpiperazine)
Transport Hazard Class: 3 (Flammable liquids), 8 (Corrosive substances)
Packing Group: II
Label Required: Flammable liquid, corrosive
Marine Pollutant: Not classified as marine pollutant based on available data
Special Precautions: Handle and transport in accordance with DOT, IMDG, and IATA regulations
OSHA: Hazardous chemical as defined by OSHA Hazard Communication Standard
TSCA: Listed on the Toxic Substances Control Act Inventory
SARA Title III: Not subject to reporting requirements under Sections 302, 304, or 313
State Regulations: Listed on some state’s right-to-know chemical inventories
REACH/CLP (EU): Registered, classified and labeled according to EU regulations
Other International Inventories: Listed in Canada (DSL), Australia (AICS), Japan (ENCS), and South Korea (KECI)
