Product Name: 1-(3-Chloropropyl)-4-Methylpiperazine
Chemical Formula: C8H17ClN2
CAS Number: 28122-14-1
Recommended Use: Laboratory, research, and intermediate chemical synthesis
Supplier: Details depend on the manufacturer. Ensure relevant address, emergency numbers, and contact information remain visible on all shipping documentation.
Synonyms: N-Methyl-N-(3-chloropropyl)piperazine
GHS Classification: Acute toxicity (oral, dermal), Skin irritation, Eye irritation, Specific target organ toxicity — single exposure
Hazard Symbols: Skull and crossbones, Exclamation mark
Pictograms: GHS06 (toxicity), GHS07 (irritant)
Signal Word: Danger
Hazard Statements: Harmful if swallowed, Causes skin and eye irritation, May cause respiratory irritation, May cause organ damage through prolonged or repeated exposure
Precautionary Statements: Wash hands thoroughly after handling, Avoid breathing dust/fume/gas/mist/vapors/spray, Use only outdoors or in a well-ventilated area, Wear protective gloves/protective clothing/eye protection/face protection, Do not eat, drink, or smoke while using this product
Chemical Name: 1-(3-Chloropropyl)-4-Methylpiperazine
Purity: Greater than 97%
Molecular Weight: 176.69 g/mol
Impurities: Related piperazine derivatives (less than 3%), residual solvents may be present in low ppm levels from synthesis
Occupational Exposure Limits: Not established for this specific compound, follow generic piperazine guidelines pending regulatory update
Inhalation: Remove victim to fresh air, support breathing as needed, provide oxygen if breathing becomes difficult, seek medical attention if symptoms persist
Skin Contact: Immediately wash with plenty of soap and water, remove contaminated clothing and shoes, seek medical help if irritation or other symptoms occur
Eye Contact: Rinse cautiously with water for at least 15 minutes, keep eyelids apart, remove contact lenses if present and easy to do, obtain medical attention
Ingestion: Rinse mouth, do not induce vomiting unless directed by medical personnel, give water or milk to dilute if conscious, immediately seek medical advice
Symptoms: Nausea, headache, dizziness, skin redness, eye watering, respiratory difficulties, severe cases may bring more acute toxicity signs
Suitable Extinguishing Media: Water spray, dry chemical, carbon dioxide, alcohol-resistant foam
Unsuitable Media: Direct water jets may spread fire
Hydrogen Chloride Gas: Thermal decomposition produces hazardous gasses, firefighters should use self-contained breathing apparatus and protective clothing
Fire Hazards: Flammable decomposition products, risk of explosion in a confined space from excessive heat
Advice: Move containers away from fire area, cool nearby containers with water spray if safe, avoid breathing smoke or fumes, evacuate area if fire grows beyond initial stage
Personal Precautions: Evacuate unprotected personnel from area, provide adequate ventilation, wear chemical-resistant gloves, goggles, and protective clothing
Containment: Prevent further leakage, absorb spill with inert material (vermiculite, sand), do not let product enter drains or watercourses
Clean Up Methods: Collect in closed, labeled containers for proper disposal, wash area with soap and excess water, ventilate site of spill
Environmental Precautions: Report releases to authorities as required, prevent undiluted product from entering soil, ditches, sewers, waterways
Safe Handling: Use with appropriate local exhaust ventilation, minimize dust and vapor formation, avoid breathing vapors or aerosols, do not handle until all safety precautions are understood
Hygiene Measures: Wash hands and face after handling, remove contaminated clothing before entering common areas
Storage Conditions: Store in tightly closed containers, keep in cool, dry, well-ventilated area, segregate from acids, oxidizers or incompatible chemicals
Incompatibilities: Reacts with strong oxidizing agents, acids, and strong bases, store away from food or feedstuffs
Engineering Controls: Use fume hood or chemical splash hood, maintain adequate general or local ventilation
Respiratory Protection: NIOSH-approved respirator for organic vapors if engineering controls are insufficient
Eye/Face Protection: Wear splash-proof safety goggles, use face shields for large volumes or splashes
Skin Protection: Wear chemical-resistant gloves (nitrile, neoprene), long sleeves, lab coat, and chemical apron
Exposure Limits: Not assigned for compound, use caution and standard limits for unknown toxicity piperazine derivatives
Work Practice Controls: Do not eat, drink, or smoke while using this material, maintain strict housekeeping in chemical handling areas
Physical State: Liquid or solid, colorless to pale yellow depending on purity
Odor: Slight, amine-like
Odor Threshold: Not established for this compound
pH: Neutral to slightly basic based on solution of the compound
Melting Point: 8 °C (approximate, varies by grade)
Boiling Point: 247–250 °C at atmospheric pressure
Flash Point: Greater than 110 °C (closed cup)
Evaporation Rate: Not measured for this specific material
Flammability: May be combustible at high temperatures
Vapor Pressure: Low at room temperature
Vapor Density: Not established, likely heavier than air
Solubility: Soluble in water and alcohols
Partition Coefficient: Not available
Decomposition Temperature: Begins to decompose above 250 °C
Viscosity: Not measured
Appearance: Oily liquid, may crystallize at low temperatures
Chemical Stability: Stable under recommended storage conditions, light-sensitive over long term
Reactivity: Avoid contact with oxidizing agents, acids, acid chlorides
Hazardous Decomposition Products: Hydrogen chloride, carbon monoxide, nitrogen oxides, amines
Polymerization: Not expected to occur under normal conditions
Conditions to Avoid: Strong heating, open flames, high humidity, unsealed containers
Acute Toxicity (estimated): LD50 (oral, rat): Data restricted, piperazine derivatives generally show moderate acute toxicity
Chronic Toxicity: Long-term exposure may impact liver, kidney, or central nervous system functions
Routes of Exposure: Inhalation, skin and eye contact, ingestion
Irritation and Sensitization: Causes moderate to severe skin and eye irritation, may trigger respiratory discomfort
Carcinogenicity: Not listed by IARC, NTP, OSHA; data for piperazine analogs indicate no clear evidence of carcinogenic potential
Reproductive Effects: No data available for this specific compound, piperazine core generally lacks known teratogenic risk at non-lethal doses
Additional Information: Some individuals may be more sensitive; workplace monitoring recommended for repeated use
Ecotoxicity: No measured data on aquatic or terrestrial toxicity; piperazine derivatives have shown low to moderate toxicity to fish and daphnia in related studies
Persistence and Degradability: May be persistent in environment without efficient wastewater treatment, biodegradation not rapid
Bioaccumulation Potential: Low to moderate based on octanol-water partition estimations, exact data unavailable
Mobility in Soil: Expected to be mobile, soluble in water
Other Adverse Effects: Release into waterways may affect aquatic life and microbial populations; regulatory authorities must be notified of larger spills
Disposal Methods: Incinerate in a chemical incinerator equipped with afterburner and scrubber, landfill as permitted by local, state, and federal laws
Container Disposal: Rinse thoroughly, triple rinsing containers before recycling or disposal
Special Precautions: Avoid discharge to the environment, treat as hazardous waste, segregate from general trash
Waste Codes: Not specifically assigned, classify as hazardous per local regulations for amine organics with halogen substitution
UN Number: Not regulated for transport under most global guidelines, check country-specific requirements
Transport Hazard Class: Not classified; some authorities may require special handling as toxic or corrosive material
Packing Group: Not assigned
Labels Required: Use “Toxic” and “Corrosive” handling labels where applicable
Special Transport Precautions: Secure tightly closed containers, segregate from foodstuffs and incompatible chemicals, provide emergency contact number with shipment
Marine Pollutant: Not determined, evaluate based on shipment size and jurisdiction
Regulatory Status: Not listed on U.S. TSCA inventory, subject to control as a new chemical substance in many countries
SARA Title III: Not considered hazardous under Sections 302, 311/312, 313
REACH Registration: Required for importation into the EU over threshold volumes
OSHA Classification: Considered hazardous due to acute toxicity and corrosivity
International Regulations: Subject to chemical safety assessment in most jurisdictions, export and import may require permits, chemical is not on major lists of banned substances
Workplace Labelling: Provide clear hazard communication, ensure safety data is available to all workers, keep labels intact and up to date
