Product Name: 1,2,2,6,6-Pentamethylpiperidin-4-ol
Chemical Family: Hindered amine alcohol
Synonyms: 4-Hydroxy-1,2,2,6,6-pentamethylpiperidine
CAS Number: 34520-39-5
Recommended Use: Intermediate in organic synthesis, light stabilizer in polymers
Supplier Information: Contact chemical distributor or manufacturer for current address and emergency phone numbers
Emergency Contact: Reach out to CHEMTREC for transportation emergencies or the regional poison center for exposure information
GHS Classification: Skin corrosion/irritation: Category 2; Eye damage/irritation: Category 2A; Specific target organ toxicity (single exposure): Category 3; Acute toxicity (oral): Category 4
Signal Word: Warning
Hazard Statements: Harmful if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Pictograms: Exclamation mark symbol
Precautionary Statements: Avoid contact with skin and eyes. Wash hands thoroughly after handling. Use only in a well-ventilated area. Do not eat, drink or smoke during use.
Potential Health Effects: Inhalation may result in coughing and throat irritation. Skin contact leads to redness and possible burns. Prolonged exposure adds greater risk to sensitive skin or eyes.
Chemical Name: 1,2,2,6,6-Pentamethylpiperidin-4-ol
CAS No: 34520-39-5
Concentration: ≥98% by weight
Impurities: Trace amounts of organic byproducts associated with piperidine synthesis; specific information varies by supplier.
Molecular Formula: C10H21NO
Molecular Weight: 171.28 g/mol
Other Components: No hazardous impurities present above applicable regulatory thresholds.
Eye Contact: Rinse immediately with plenty of water for at least 15 minutes, lifting eyelids periodically. Get medical attention if irritation persists.
Skin Contact: Wash affected area with soap and water, removing contaminated clothing and shoes. Seek medical advice for redness or persistent discomfort.
Inhalation: Move person to fresh air. If breathing is labored, supply oxygen if trained. Seek medical help for persistent symptoms.
Ingestion: Rinse mouth, drink several glasses of water. Do not induce vomiting unless directed by trained personnel. Get medical assistance promptly.
Special Notes for Medical Personnel: Treat symptomatically and support as needed. There is no specific antidote, so supportive measures dominate care.
Suitable Extinguishing Media: Carbon dioxide, dry chemical powder, alcohol-resistant foam, or water spray; use what is available for the surrounding fire.
Unsuitable Media: High pressure water jet may spread material.
Hazardous Combustion Products: Carbon monoxide, carbon dioxide, nitrogen oxides, possible toxic organic vapors.
Special Protective Equipment: Wear full firefighting gear including self-contained breathing apparatus.
Fire & Explosion Hazards: Fine dust can form an explosive mixture in air. Material may burn but does not ignite readily.
Advice for Firefighters: Keep upwind of fire, contain contaminated runoff to prevent environmental contamination.
Personal Precautions: Evacuate unnecessary personnel, use protective equipment including gloves, goggles, lab coat, and, if dust is generated, suitable respirator.
Environmental Precautions: Prevent entry into waterways, drains, and soil. Contain spills with absorbent material.
Cleanup Methods: Carefully sweep or scoop up without creating dust, place in labeled container for disposal. Wash residue with ample water.
Further Management: Ventilate area before resuming work, remove contaminated materials for appropriate disposal, inform responsible authorities if large spill occurs.
Handling: Work in well-ventilated spaces. Avoid breathing vapors, contact with skin, eyes, and clothing. Do not eat, drink, or smoke during use. Wash hands after handling.
Storage: Keep container tightly closed in a cool, dry, and well-ventilated location. Store away from strong oxidizers and sources of ignition. Label containers accurately.
Special Instructions: Do not reuse containers. Keep away from food and beverages. Follow good industrial hygiene practices.
Incompatibilities: Strong oxidizers and acids, strong bases, and moisture.
Occupational Exposure Limits: No established ACGIH or OSHA exposure limits for this compound.
Engineering Controls: Use chemical fume hood or local ventilation to control airborne concentrations. Install eyewash stations and safety showers.
Personal Protective Equipment: Wear chemical-resistant gloves, lab coat, safety goggles, and, where dust or vapor is present, respiratory protection such as NIOSH-approved respirators.
Hygienic Measures: Maintain clean working environment. Change contaminated clothing before leaving work area.
Appearance: White to off-white crystalline solid
Odor: Characteristic amine-like
Odor Threshold: Not determined
pH: Slightly basic in water
Boiling Point: 241 °C at standard pressure
Melting Point: 110-113 °C
Flash Point: 98 °C (closed cup)
Evaporation Rate: Not applicable (solid)
Flammability: Not classified as highly flammable
Vapor Pressure: Negligible at ambient conditions
Vapor Density: Not determined
Solubility: Slightly soluble in water, more soluble in organic solvents
Partition Coefficient (log Kow): Estimated 2.1–2.6
Decomposition Temperature: Not precisely established. Thermal decomposition at elevated temperatures can occur.
Chemical Stability: Stable under recommended storage conditions. Extended exposure to heat or light may accelerate degradation.
Reactivity: May react with strong oxidizing agents. Potential to form flammable or reactive vapors with incompatible substances.
Possible Hazardous Reactions: Formation of toxic fumes under fire conditions (CO, NOx).
Incompatible Materials: Strong acids, alkalis, oxidizers.
Hazardous Decomposition Products: Generates CO, CO₂, NOx if combusted or decomposed at high temperature.
Polymerization: Not known to polymerize under normal conditions.
Likely Routes of Exposure: Inhalation, dermal absorption, ingestion, eye contact
Acute Toxicity: Harmful if swallowed or inhaled; animal studies suggest oral LD50 (rat) between 300-2000 mg/kg.
Skin Corrosion/Irritation: May cause moderate to severe irritation following prolonged or repeated contact.
Eye Damage/Irritation: Contact can cause redness, pain, and possibly lasting eye injury.
Respiratory Effects: Dust or vapor causes coughing, sore throat, and discomfort.
Chronic Effects: No long-term effects firmly established; overexposure may aggravate dermatitis or cause sensitization in predisposed individuals.
Carcinogenicity: Not listed by IARC, ACGIH, NTP, or OSHA as a carcinogen.
Mutagenicity and Reproductive Effects: No data available for mutagenic or reproductive toxicity.
Target Organs: Eyes, skin, respiratory tract.
Ecotoxicity: Not expected to present significant toxicity to aquatic organisms at low concentrations, but large spills may cause harm to fish or invertebrates.
Persistence and Degradability: Degradation in the environment occurs slowly; the compound has moderate persistence in soil and water.
Bioaccumulative Potential: Moderate potential for bioaccumulation; measured or estimated log Kow in range 2.1–2.6.
Mobility in Soil: Limited mobility; compound binds to soils and organic matter.
Other Adverse Effects: Spills may impact microbial communities in soil or water.
Waste Treatment Methods: Incinerate in a licensed facility with appropriate air pollution controls, or send to approved hazardous waste disposal site.
Contaminated Packaging: Handle as hazardous material; do not reuse containers. Rinse with compatible solvent before disposal.
Precautions: Avoid disposal to sewer, surface, or ground waters. Follow local, regional, and national regulations.
UN Number: Not regulated by UN for transportation purposes under standard chemical transport guidelines
Proper Shipping Name: Non-hazardous for air, ground, and sea under typical handling classifications
Transport Hazard Class: Not applicable
Packing Group: Not applicable
Marine Pollutant: No
Special Precautions: Secure tightly-closed containers in upright position; avoid exposure to high temperatures during transport
US TSCA: Listed
SARA Title III Section 313: Not subject to reporting
RCRA Status: Not a listed hazardous waste
REACH Status (EU): Registration or notification required where applicable
WHMIS Classification (Canada): Classified as D2B – Toxic Material at workplace concentrations
OSHA Hazards: Irritant
Other National Inventories: Check with local regulations for inclusion on inventories in Japan, Korea, Australia, China, etc.
Labelling Requirements: Chemical name, hazards, emergency phone numbers, and supplier details required on labels for workplace use.
