Product Name: 1,1'-Thiocarbonylbis(Imidazole)
Chemical Formula: C7H6N4S
CAS Number: 6160-65-2
Synonyms: TCBI, Imidazol-1-yl Thiocarbonate
Recommended Use: Organic synthesis, peptide coupling reagent
Supplier Details: Manufacturer or distributor contact information as found on commercial packaging
Emergency Contact: Refer to local Poison Control Center or emergency service number provided
GHS Classification: Harmful if swallowed, skin sensitizer, causes eye and skin irritation
Hazard Symbols: Exclamation mark
Signal Word: Warning
Hazard Statements: May cause respiratory tract, eye, or skin irritation; harmful on contact; may cause allergic skin reaction; may be harmful if inhaled
Precautionary Statements: Avoid ingestion, skin contact, and inhalation; use only in well-ventilated areas; wear protective gear including gloves, goggles, and lab coats
Pictogram: Follow GHS pictograms for skin and eye irritant
Other Hazards: Dust or powder may cause discomfort; possible respiratory risk if fine particles disperse in air
Chemical Identity: 1,1'-Thiocarbonylbis(Imidazole)
CAS Number: 6160-65-2
Concentration: 98% or greater (pure form as supplied for lab or industrial use)
Impurities: Trace imidazole derivatives from manufacturing process, content typically less than 2%
Hazard Components: Main hazard comes from parent compound, impurities not classified as especially hazardous
Eye Contact: Rinse eyes cautiously with water, remove contact lenses if present, continue rinsing for at least 15 minutes, seek medical attention
Skin Contact: Wash with plenty of soap and water, remove contaminated clothing, seek medical attention for irritation or allergic reaction
Inhalation: Move to fresh air, keep at rest, provide artificial respiration if breathing stops, seek immediate medical care if symptoms like coughing or throat irritation persist
Ingestion: Rinse mouth with water, do not induce vomiting, get medical help promptly
Notes for Physician: Treat symptomatically, monitor allergic and respiratory responses closely
Suitable Extinguishing Media: Use dry chemical powder, carbon dioxide, or alcohol-resistant foam; avoid use of water jet
Specific Hazards: Thermal decomposition may release toxic gases such as carbon oxides, nitrogen oxides, and sulfur oxides
Protective Equipment for Firefighters: Self-contained breathing apparatus and full protective clothing
Special Procedures: Cool exposed containers with water spray; prevent runoff from fire control from entering drains or waterways
Personal Precautions: Evacuate unnecessary personnel, ventilate area, avoid breathing dust, wear protective clothing, gloves, and goggles
Environmental Precautions: Prevent spillage from entering drains, surface or groundwater
Containment Methods: Sweep up without generating dust, collect in suitable, sealed containers for disposal
Cleanup Procedures: Wash spill site thoroughly after cleanup, decontaminate equipment and clothing used during handling
Handling: Use within a properly ventilated area; avoid formation of dust; do not get in eyes, on skin, or on clothing; wash hands after handling; provide easy access to eyewash stations and safety showers
Storage Conditions: Store in a cool, dry, well-ventilated area away from incompatible substances such as strong oxidizers and strong acids
Packaging: Store in tightly sealed original containers; ensure label information remains intact and legible
Special Considerations: Keep out of reach of untrained individuals; inspect containers regularly for signs of degradation or leaks
Engineering Controls: Use local exhaust or general ventilation to minimize airborne concentrations
Personal Protective Equipment: Chemical-resistant gloves (nitrile or neoprene), safety goggles, lab coat, closed-toe shoes
Respiratory Protection: Use approved respirators if dust or vapors exceed recommended exposure limits; for large-scale operations, implement respiratory protection program
Occupational Exposure Limits: No specific exposure limits set by OSHA, ACGIH, or other regulatory bodies; use good laboratory practice to minimize exposure
Hygiene Practices: Wash hands and exposed skin thoroughly after handling; do not eat, drink, or smoke around this chemical
Appearance: White or off-white crystalline solid or powder
Odor: Odorless or slight characteristic odor
Molecular Weight: 178.22 g/mol
Melting Point: 143 - 146°C
Boiling Point: Decomposes before boiling
Solubility: Slightly soluble in water, soluble in common organic solvents like DMSO, DMF, acetonitrile
Vapor Pressure: Not significant at room temperature
Density: Approximately 1.38 g/cm³
pH (solution): Not classified as acidic or basic in weak aqueous solution
Other Data: Not explosive, non-flammable under normal conditions
Chemical Stability: Stable under recommended storage and handling conditions
Possible Hazardous Reactions: May react with strong oxidizers, acids, or bases; decomposition may generate imidazole derivatives and toxic sulfur, nitrogen, or carbon oxides
Conditions to Avoid: Excess moisture, high heat, open flames, sources of ignition
Incompatible Materials: Strong oxidizing agents, strong acids, strong bases
Hazardous Decomposition Products: Carbon oxides (CO, CO₂), nitrogen oxides (NOₓ), sulfur oxides (SOₓ), imidazole fumes
Routes of Exposure: Inhalation, ingestion, skin and eye contact
Acute Effects: Causes eye and skin irritation, possible allergic skin reaction, respiratory tract irritation
Chronic Effects: Prolonged or repeated exposure may cause dermatitis or sensitization
LD50 (Oral, Rat): 610 mg/kg (literature estimate)
Symptoms: Burning sensation, redness, pain at site of contact, possible cough or wheezing if inhaled
Carcinogenic Potential: Not listed as carcinogen by NTP, IARC, or OSHA
Other Data: No evidence of mutagenicity or reproductive toxicity from short-term laboratory data
Aquatic Toxicity: Data limited, not expected to be acutely toxic at low concentrations based on chemical structure
Persistence and Degradability: May undergo hydrolysis or photolytic decomposition in nature; expected to persist in soil or water for an extended period
Bioaccumulation Potential: Low potential for bioaccumulation
Mobility in Soil: Likely low, binds to organic matter
Other Harmful Effects: Spilled product could cause localized damage to aquatic environments if significant quantities released
Disposal Methods: Dispose as hazardous chemical waste in accordance with local, regional, and national regulations; treat as organic lab waste
Packaging Disposal: Triple-rinse empty containers before disposal, never reuse for food or drink
Precautions: Incinerate or landfill only in approved facilities equipped for hazardous waste
Do Not: Do not dispose in regular trash, sewers, or general landfill
UN Number: Not regulated under normal shipping conditions
Proper Shipping Name: Not classified as a hazardous material for transport
Transport Hazard Class: Not applicable
Packing Group: Not applicable
Labels Required: None required for small laboratory quantities; follow all regulations for bulk shipment
Special Precautions: Protect containers from crushing or rough handling; avoid extreme temperatures during transit
Inventory Status: Listed on TSCA (US), EINECS/ELINCS (Europe), and similar inventories
OSHA Hazard Classification: Irritant, sensitizer
SARA Title III (Sections 311/312): Considered as hazardous based on acute health and chronic health effects
California Proposition 65: Not listed
REACH Status: Subject to registration obligations as an industrial chemical in the EU
Other Local, State, Federal Regulations: Comply with all applicable regulations concerning safe use, storage, disposal, and transport
