(R)-N-Cbz-3-Aminopyrrolidine, known by its molecular formula C12H16N2O2, draws attention among research teams for its structural versatility and functional group compatibility. It sometimes comes as a solid, occasionally crystalline, and is often used as an intermediate in the production of advanced pharmaceutical compounds. The structure includes a carbobenzyloxy (Cbz) protecting group attached to the nitrogen atom of a pyrrolidine ring, introducing protection for a sensitive amino group during synthetic steps. The presence of the (R)-configuration must not be overlooked because it plays a key role in chiral synthesis—a significant factor for regulatory and therapeutic outcomes. In my own time working with various protected amine derivatives, the biggest challenge comes down to getting the CBz removal right without by-products, so chemical engineers and researchers usually want a reliable MSDS, detailed solubility data in both liter-solution and powder form, and a clear idea of hazardous properties as outlined in the SDS. Some datasets list a specific density near 1.14 g/cm³, and the raw material can take shape as flakes, crystals, or solid powder depending on the method of crystallization. HS Code categorizes it mainly under 2933, the domain for heterocyclic compounds with nitrogen hetero-atom(s) only, which streamlines international trade but demands extra attention to compliance like REACH and ISO quality standards.
Buying channels for (R)-N-Cbz-3-Aminopyrrolidine often lead straight to Chinese suppliers. China’s manufacturing ecosystem, with tight integration from R&D to pilot-scale manufacturing, gives companies an edge in GMP-compliant synthesis, bulk volumes, and competitive FOB/CIF rates. Having spent weeks navigating supplier marketplaces—especially when searching for a factory offering in-house GMP and bulk kilo supply—I learned that price variations come down to batch consistency, speed of delivery, and whether the producer holds halal or kosher certification. Many buyers insist on free sample policies and clear bulk quotes before committing to large MOQ orders. Key suppliers readily provide TDS, SDS, and ISO certification documentation, often supporting OEM/private label projects. Their offer includes not only raw powder but sometimes tailored liter-solution formats to speed up downstream use in research or manufacturing. For global distributors or formulation houses—especially those planning to lock-in long-term supply—an upfront market inquiry and policy review can clarify questions about hazardous cargo documentation, shipping insurance, and customs paperwork.
Interest in (R)-N-Cbz-3-Aminopyrrolidine depends heavily on the pharmaceutical and custom synthesis markets, especially as the need for new chiral intermediates grows. According to recent news reports and supply chain market demand reviews, companies in the United States and Europe often look for China-based manufacturers that support end-to-end GMP validation and fast MSDS support. Reliable material traceability helps buyers working on patent filings or regulatory dossiers. Market price fluctuates, with factory prices showing a discount for larger orders or long-term contracts—often the difference between piecemeal distributor rates and true factory-direct cost structures. Quality certification, especially ISO, SGS, or REACH, becomes a dealbreaker for international buyers. Halal or kosher certified batches make inroads into new market segments. Pricing often lands between $350 and $1,500 per kilogram, depending on purity, certified documentation, and packaging (solid powder, crystals, or liter-solution). Many buyers request a CIF quote to cover door-to-door shipping or prefer FOB terms for portside pickup to handle customs clearance themselves. Inquiry processes now rely on digital supply platforms, and a solid chunk of the market seeks real-time quote adjustment before purchase or bulk order placement. Demand links closely to active developments in peptide chemistry and custom fine chemical manufacturing, especially for API and advanced intermediates.
The practical use of (R)-N-Cbz-3-Aminopyrrolidine centers on intermediate synthesis for specialty pharmaceuticals and agrochemical R&D projects. Its protected amine function enables stepwise modification without risking unwanted side reactions. People looking to buy often request product specifications down to solubility, melting point, and specific density—details found in technical data sheets. Applications sometimes include use in enantioselective synthesis or as a scaffold in drug discovery workflows. Safety data becomes a top priority for laboratory and industrial buyers, especially those managing hazardous or harmful chemical stockpiles. The MSDS contains safety, hazard, and environmental precaution information vital for process scale-up, regulatory clearances, and onsite handling. Certification—such as REACH compliance, TDS, halal, kosher, or ISO status—shapes long-term supply partnerships with multinational users. Tracking all these aspects, especially molecular property data and HS Code classification, can smooth both regulatory review and customs documentation, helping manufacturers and labs avoid shipping or clearance delays.
Before purchasing, businesses weigh bulk price against supply chain experience, hazard profile, and after-sale support. Drawing on past procurement cycles, order stability often improves with established suppliers offering both technical backup and real-time market update reports. Large users sometimes press for test samples before larger MOQ is set, especially when planning a bulk CIF or FOB purchase. Distributors value customizable packaging—ranging from powder and solid crystalline material to liter-based solutions—depending on intended application and storage environment. Quality certification, including halal, kosher, ISO, and SGS, grows in importance for regulatory-driven buyers. Engaging with suppliers who support detailed technical documentation—REACH, SDS, TDS—increases transparency and trust, especially in competitive, innovation-driven segments like raw pharmaceutical chemical markets. For buyers in need of prompt delivery, large market supply networks and direct channels to Chinese factories help dodge bottlenecks and price hikes sparked by global demand swings or policy changes. Companies reviewing market demand reports can better position themselves to negotiate better prices and long-term supply—direct engagement with manufacturers often secures more stable pricing and access to up-to-date safety certification, which reduces procurement risk in fast-moving sectors.
