Talking chemistry and production, (R)-(-)-2-Hydroxymethylpyrrolidine has built its place as an essential raw material for both small research labs and large scale pharmaceutical manufacturers. This compound, often supplied as a colorless to pale solid or sometimes a liquid, shows a molecular formula of C5H11NO and a specific density of about 0.99 g/cm³ at room temperature. With a CAS number of 13344-20-2 and HS Code often classified under 29333999, this chemical draws serious attention among users looking for chiral building blocks and intermediates in the synthesis of active pharmaceutical ingredients. That matters for anyone striving for purity and high yield in the finished product. Chinese suppliers and factories have stepped up to produce consistent, GMP-grade batches, giving buyers access to affordable factory price and bulk inquiry solutions.
Applications for (R)-(-)-2-Hydroxymethylpyrrolidine stretch beyond research and into pharmaceuticals, flavors, specialty chemicals, and advanced materials. Its strong performance as a chiral auxiliary makes it a favorite for demanding synthesis, as it helps drive selectivity in reactions. You've got chemical suppliers offering different package sizes, ranging from small sample bottles to 25-liter drums, meeting the needs of small labs and bulk buyers. The supply chain in China covers not only local demand but also ships globally under export CIF or FOB terms. Most reputable manufacturers ensure products come with MSDS (Material Safety Data Sheet), TDS (Technical Data Sheet), and ISO, SGS, REACH, and GMP certifications; some even provide halal and kosher certificates for clients with strict regulatory or ethical guidelines. Quality certifications have become a real factor in choosing suppliers these days. The industry demands trusted partners who not only promise market-competitive factory pricing, but also back it up with audit-ready documentation and traceability.
On the lab bench, (R)-(-)-2-Hydroxymethylpyrrolidine stands as a versatile secondary amine with an attached primary alcohol group. These functional groups explain its widespread use as a resolving agent and catalyst precursor. Pure form arrives as flakes or powder, although some suppliers offer solutions or liquid-crystal forms for easier mixing. Molecular structure directly impacts its performance in asymmetric syntheses, which is why many buyers look for a detailed structural report or NMR analysis before purchase. The compound remains sensitive to moisture and should get sealed tight to prevent degradation. Storage advice sticks to cool, dry, well-ventilated conditions, away from strong oxidants and acids, a detail that matters for lab safety and compliance with hazardous materials protocols.
The global market for (R)-(-)-2-Hydroxymethylpyrrolidine has shown steady demand growth, driven by new drug development pipelines and a tightening regulatory focus on enantiomeric purity. Chinese manufacturers lead with cost-effective production and robust export channels. As a buyer or distributor, pricing structure depends heavily on MOQ (Minimum Order Quantity), whether you buy samples, order by the kilo, or go for a 200-kg drum. Some suppliers can provide quick quotes or even free samples for qualified buyers. Market reports place this chiral secondary amine in a mid-to-high demand tier, often reflecting changes in pharmaceutical policy and tech upgrades inside Chinese supply chains. Import/export trends reflect opportunities for bulk purchase at consistently competitive rates, with policy compliance and REACH status impacting access in the European market.
Handling (R)-(-)-2-Hydroxymethylpyrrolidine in the lab or factory puts safety at the front of the process. The MSDS covers risk factors, such as hazardous classification and first aid steps. Inhalation or accidental contact involves strict PPE and fume hood use, with details about proper disposal of spills and contaminated material. Companies serious about GMP standards run regular in-house audits and third-party checks to make sure each batch meets the relevant specifications. Labels must include clear hazard symbols and precautionary statements, helping all workers, from material handlers to process chemists, maintain ISO and SGS best practice. Supply policy in leading Chinese factories now ties safe handling training and documentation to product release, making safety and traceability a single streamlined process.
Long years in the chemical trade show that buyers care about more than the chemical’s price per kilo. More want transparency—batch-specific COA, updated SDS, verifiable GMP manufacturing, and proof of third-party certification, including halal or kosher when needed. Direct conversations with factory sales teams and a willingness to negotiate—MOQ, discounts, shipping terms—make trusted supplier relationships. Inquiries about purity, specific density, and appearance (flakes, powder, pearls) tell you who knows their product and stands behind their quality. As demand for chiral building blocks increases, buyers must sort through many offers, choosing only those that prove both compliance and consistent delivery. Distributors and bulk buyers track market supply closely, adjusting order sizes in line with reports on global demand and local policy shifts.
Right now, better transparency in testing data and certification processes would help buyers differentiate between bulk-run and high-purity batches. Online distributor channels with bundling options—paired SDS, COAs, sample packs—could speed up decision cycles. Factories that update documentation regularly and push ongoing training in safe hazardous chemical handling gain trust and keep repeat buyers. Increasing demand for chiral intermediates sets the scene for more rigorous audits, more thorough documentation, and clearer application case studies in news and reports. Tailored, real-time MOQ and quotation systems through web portals could ease client inquiry and build trust between batches. Factories with a track record for responsive communication, knowledge about molecular structure and properties, and a readiness to help on compliance score high in a marketplace where product reliability matters as much as price.
