Looking at (S)-Pyrrolidine-2-Carbonitrile, you spot a five-membered saturated ring and a nitrile group tagging off the second carbon. The formula goes as C5H8N2, and its specific density sits close to 1.06 g/cm3. Depending on production, you run across it as a white crystalline solid, sometimes as flakes or fine powder, rarely in anything that looks like pearls. Molecular structure, with the cyano substituent on position-2, pushes this intermediate right into the workflow for asymmetric synthesis. HS Code generally runs in the 2933 series, helping customs and logistics managers pin down tariff rates globally. Folks handling (S)-Pyrrolidine-2-Carbonitrile often check the melting point, which lives north of 45°C, and run quick NMR scans to prove batch identity, staying alert for the specific S-configuration marker. Whether you’re ordering bulk from a factory in Jiangsu or picking up a sample from a European distributor, it pays to confirm a MSDS copy, REACH registration, and TDS with a breakdown of molecular property and hazard classification.
Chinese manufacturers handle a big slice of (S)-Pyrrolidine-2-Carbonitrile global output. Factory clusters built around Suzhou, Nanjing, and Shanghai combine ISO and GMP facilities under one roof, toggling between pilot and large-lot production with tight attention to quality. Buyers exploring direct supply routes usually ask for OEM options, review GMP certificates, and look for halal and kosher badges, especially for pharmaceutical applications. It gets competitive on raw material sourcing — acetonitrile, pyrrolidine, and the right catalysts steer the final CFR or FOB price, and traders keep an eye on fluctuations in upstream chemicals for clues on where bulk prices go next. CIF terms out of China pack in hazard-class packaging, handling requirements, and full SDS documentation as part of the export process. Some Chinese suppliers open free-sample programs with MOQs dipping to 100 grams, letting R&D labs across North America and Europe run real-world application checks before launch.
(S)-Pyrrolidine-2-Carbonitrile holds steady application in chiral intermediates and as a key step in the manufacture of specialty APIs — sitagliptin is the classic example, where the S-enantiomer is non-negotiable for regulatory approval. Buyers for this material usually scan a distributor’s offer for REACH, ISO, SGS compliance, and certification matching the intended final use. Over-the-counter market reports peg global demand at a steady climb of 8% annually, with a surge in peptide synthesis and agrochemical research. News from European regulators shows tightening requirements for TDS and GMP trail, pushing manufacturers in China, India, and the EU to extend quality manuals to include everything from trace metals to UV-Vis spectra. With policies tightening, especially post-Brexit and with new flavorings rules in the US, manufacturers have to think about kosher, halal, and even vegan certification to keep doors open with global buyers juggling risk and compliance.
Digging through the latest MSDS sheets, (S)-Pyrrolidine-2-Carbonitrile slots under hazardous class; harmful on inhalation and contact with skin. Direct ingestion or inhalation gets flagged as dangerous, pushing warehouse and logistic teams to rely on UN-approved drums, lined bags, and secondary containment. Operators wear gloves, goggles, and, in the event of a spill, fast-action spill kits come right off the wall. Proper air exchange and negative pressure storage keep vapor risks in check. Not every lab corners the same volume, so safe stacking and temperature checks — often below 25°C and well away from acids — matter, especially for material in flake or powder form. Logistics partners value clear labeling and streamlined customs documentation, as delays over incomplete SDS checklists or missing hazard pictograms can trigger fines and expensive reshipping. Exporters use labels with HS codes, hazard diamonds, and manufacturer traceability, keeping everyone, from shippers to end users, in the clear.
Buyers focused on securing a new source of (S)-Pyrrolidine-2-Carbonitrile weigh factory pricing against the reliability of shipment and batch consistency. It’s common to see offers with MOQ breakpoints and price discounts in larger bulk lots — get over 100 kg, and the per kilo price often drops by 15–25%. Some distributors, especially those integrating their supply chains from China, open up three-tiered pricing: sample, R&D, and production lot. Bulk buyers, especially API makers, pull lab samples and request current market reports, sizing up spot prices and demand swings quarter by quarter. A solid purchasing team keeps both CIF and FOB quotes on the table, comparing transit risks and total landed cost. International buyers stay tuned to policy shifts, such as hazardous raw material import bans or ISO certification updates, before signing off on larger contracts. Practical buyers always factor in supply interruptions — COVID-era blockages taught everyone to value a robust network of certified and alternative producers, running parallel quotes even if the first line is a trusted supplier.
Applications for (S)-Pyrrolidine-2-Carbonitrile reach far outside mainline APIs. It has made its way into catalyst design, molecular ligands research, and high-value chemical raw material blends. Even with strong market competition, wide access to technical data — full specification sheets, structural diagrams, molecular property documentation — and ISO-backed QA programs allows end users to make tough calls between price and traceability. Market news cycles lately highlight raw material supply swings and surges in freight rates (especially sea-to-air transitions), prodding buyers and suppliers alike to push for certificates (SDS, REACH, TDS) with each lot, regardless of volume. Distributors answering inquiries now bundle technical support, supplying density curves, storage advice, or even reference spectra for batch-to-batch verification. Buyers face new complications from evolving local laws, making it crucial to select manufacturers with up-to-date halal, kosher, or even OEM-certifiable documentation, so that material shifts from the warehouse to production floor without compliance headaches.
