(S)-3-Hydroxypyrrolidine shows up in plenty of chemical processes, both in labs and at industrial scales. Chemists recognize this molecule’s structure: a solid or crystalline powder, sometimes flakes, marked by a single chiral center. The chemical formula, C4H9NO, and specific density around 1.1–1.2 g/cm³, point out its value as a building block for pharmaceuticals and specialty chemicals. HS Code 2933990099 usually batch-registers this item for international shipment. Molecular property and CAS registry number (109431-24-7) feature on all documentation, which is crucial for customs clearance or technical review. Looking at the MSDS, (S)-3-Hydroxypyrrolidine sits in the safe-to-handle range, though, as with all raw materials containing nitrogen, one works with gloves and eye protection in a well-ventilated area. It rarely shows up as an isolated product in markets outside China; most requests for samples and bulk quantities go directly to Chinese manufacturers.
Over the past five years, inquiries for (S)-3-Hydroxypyrrolidine from European and North American distributors focus on three things: GMP-certified manufacturing, competitive CIF/FOB price for bulk orders, and reliable third-party lab certificates—ISO9001, SGS, REACH, Halal, or Kosher. Chinese factories dominate the supply chain, with OEM contract options for formulation or packaging. Due to rising demand in pharma—intermediates for chiral drugs or catalysts—MOQ on quotation rarely dips below 1–5 kg for lab grade and 10–50 kg for industrial batches. Getting a sample involves clearing customs advice (even free samples must come with SDS, COA, TDS, or technical data sheets confirming batch consistency). Global policy changes sometimes affect REACH registration for European Union imports, so suppliers often list updated supply-chain flexibility. For those in the business of chemical-buy and distribution, bulk delivery by sea (FOB/CIF) or air ex-works from China’s main ports usually sets the market price lower than any domestic alternatives. When policies shift, experienced teams in procurement scan the real-time supply news and market-demand reports for updates, using quotes from half a dozen factories to settle on one with solid QC practices.
Most people buying (S)-3-Hydroxypyrrolidine look for a raw material that suits APIs, specialty polymers, or agrochemical intermediates. As a chiral auxiliary or ligand, it shapes asymmetric syntheses, saving months in process development. In pharmaceutical companies across the US and Europe, R&D chemists leverage this compound for enantioselective drugs, treating everything from hypertension to neurological disorders. Material science teams in Japan or Korea sometimes adapt it for advanced polymer applications, chasing thermal stability or optical properties in liquid crystals. Sometimes, small manufacturers tweak the manufacturing process—swapping out more expensive precursors for this molecule—because of its cost efficiency and stable supply. Generally, people go for the solid powder form, though custom solutions in liter quantities do emerge if formulations require it.
Staying compliant means picking a supplier who sends a full suite of documentation. Most global buyers ask for GMP status and supply chain audits. ISO and SGS certification, plus COA and SDS on every batch, nail down safety and consistency, while Halal and Kosher certificates let buyers access broader markets or meet strict regulatory demand. If a customer needs liter-solution or pearl form for a novel formulation, documentation tracks not only purity, but also specific density, melting point, and hazardous material status for downstream safety. Distributors often check that the supplier’s quality certifications match end-user needs, because regulatory policies shift fast. REACH registration counts, especially for Europe-bound shipments. OEM or custom-pack services usually mean buyers request original factory paperwork, to eliminate the risk of substitution or counterfeiting along the supply chain.
Global demand for (S)-3-Hydroxypyrrolidine has moved past academic laboratories into full-scale pharma and material science production. Price competition, though, hits hardest in procurement. Factory price from a GMP manufacturer in China usually undercuts European or American re-seller quotes, yet delays appear if documentation or custom import paperwork fail QC checks. Dealing with a reputable distributor who already moves bulk product through customs can save weeks. Safety stock planning for key customers—especially those on blanket purchase agreements—demands tracking raw material supply policy in Asia. Some buyers hedge, splitting bulk orders between two suppliers, to smooth out border or logistics delays. The safest route blends open communication—MOQs, their latest policy changes, technical support, and transparent final invoices. Factory audits through third-party inspection teams keep quality high, reduce counterfeiting risk, and ensure the material you receive is what you ordered. With every market report suggesting chiral intermediate expansion, the right supplier relationship keeps your R&D and production schedule stable. Newcomers looking to buy in China save effort by asking about REACH, SDS, TDS, and both quality and certificate coverage before requesting a quote or free sample.
