Among all the pyrrolidines shaping the chemical market, (S)-2-Methyl-Pyrrolidine, HCl stands out for its sharp utility in pharma research and as a precursor in specialty chemical synthesis. Most of the demand pivots on its chirality and unique structure—C5H12ClN, molecular weight 137.61, HS code 2933399990. Buyers in medicinal chemistry value its consistency, whether as a crystalline solid, fine powder, or occasionally flakes. Density sits around 0.99 g/cm3; melting point drifts nominally near 197°C (HCl salt). Its CAS number lands at 21410-53-5, which matters for any customs brokerage or REACH registration. Checked the MSDS and REACH docs myself, and safe handling guidelines show up as vital daily reading for anyone weighing bulk purchases; don’t skip these when you compare suppliers.
In my routine procurement work, inquiries for (S)-2-Methyl-Pyrrolidine, HCl mostly aim straight to China suppliers, given their volume advantage and aggressive factory pricing. The trick is always sorting those who offer genuine GMP, ISO, and SGS certification from the horde of middlemen. Demand for supplier traceability—to know you’re not buying cut corners—climbs higher every year, especially post-COVID. Reliable chemical-buy networks favor factories that put up full TDS, SDS, and product certificates. Even halal and kosher certification pop up as key requirements for certain markets, so I’ll check those boxes on a supplier profile sheet before even considering a sample. Quotes usually come CIF, FOB, and sometimes DDP—makes life easier for us on logistics, but freight policies can shift with new regulations. Talking with distributors, I keep hearing about how MOQ policies keep changing: one year, it’s drums only, next year small-lot solutions and free-sample options become the new hook for bulk negotiations. It pays to stay in touch with market report newsletters, because raw material trends—like the price of 2-methylpyrrole or HCl—impact spot prices hard in the chemical-supply chain.
Most users I know in R&D and fine-chem production lean on this chemical for asymmetric synthesis and chiral auxiliary roles. Some see it as a material for alkaloid work. It comes formulated as either a solid or sometimes in liter-solution if the equipment setup calls for it. I’ve checked enough batch records to know labs prefer specs that spell out particle size, assay above 99%, and a clear measure of chloride content. Application segments often demand ISO and REACH-compliant certification, not just for paperwork but to meet the expectations of major multinationals in the drug intermediate business. Strict REACH, SDS, and TDS requests get rehashed in almost every request-for-quote. In my own talks with factory QC managers, I keep hearing about the push for peer-reviewed standards—those that can be certified as “quality raw materials” by both big pharma and OEM partners alike. Hazard statements on the MSDS matter in real time: local regs flag this as both harmful and hazardous, triggering extra requirements for shipment and storage, including locked cabinets, fire-resistant labeling, and trace logs for every transfer.
Requesting a sample is still the best way to sort out reliability. I’ve dealt with enough suppliers trying to balance MOQ with customer demand to know that the best partners toss in a free sample or at least a starter kit with short lead times. Policy on sample size varies by the month—some factories offer 100g free of charge, no shipping, while others keep a strict minimum tied to their current production run. Quality certifications like GMP, ISO, or specific halal-kosher labels often tip decisions for buyers in regulated spaces. Factories using new solution-processing keep touting their molecular property and density data; these numbers matter most when end-users want consistent flakes, powder, pearls, or even a custom liquidcrystal suspension. Any distributor picking up market slack spots which manufacturers give a prompt quote—usually under 24 hours—and who keep their CIF, FOB, and local delivery policies crystal clear. I found reports from the last year flagging fluctuations in market demand tied to export policies, especially from China and Southeast Asia; tariffs, bulk discount rates, and even packaging fees now make or break a deal more than just the base price.
Having tracked hundreds of shipments and certificate papers, transparency makes procurement work smoother for buyers and distributors alike. A factory’s willingness to deliver a coherent TDS, SDS, ISO certificate, and cross-checkable supply history means less friction with quality audits. Product news sometimes gives quick warnings whenever supply bottlenecks pop up—like if HCl feedstock tightens up, or new GMP-factory price routings spur a round of price recalculations. I’ve seen suppliers in China and India race to update their paperwork and certification trails every quarter, just to keep up as audits grow more intense. Reports and demand forecasts, both from government agencies and bulk traders, help buyers time their purchases—especially now, with more news focused on chemical raw materials as dual-use or flagged for strategic review.
End-users and procurement teams who overlook the specifics of sourcing (S)-2-Methyl-Pyrrolidine, HCl deal with more pushback from inbound QC teams and regulators. Customers want to see measurable physical properties—density by specific protocol, batch-to-batch structural integrity, confirmed shelf-life evidence, and absence of dangerous byproducts. I’ve had to return entire container lots after missing a single MSDS or discovering inconsistencies in a molecular formula certificate. For new buyers reading distribution market reports, the safest bet involves drilling into every part of the supply history before hitting “buy”—a full audit, traceable production log, and a certificate chain that starts at the GMP-certified plant and ends in your own warehouse. I keep files updated with examples showing which chemical-buy suppliers hold up their quality claims every time, not just on big orders but for samples, OEM picks, and even custom formulation requests. In procurement, trust is less about words than paperwork, reliable documentation, and seeing your order land in perfect condition, every single drum or liter at a time.
