(S)-(+)-2-Hydroxymethylpyrrolidine has earned an important role as a specialty intermediate, especially in pharmaceutical and fine chemical synthesis. Chemically, it presents as C5H11NO, bringing a density close to 1.03 g/cm3 and generally appears as a solid or oily liquid crystal at room temperature. Its HS Code falls under 293399 with customs, and the structure—a pyrrolidine ring bearing a chiral hydroxymethyl group—offers distinct stereochemistry for enantioselective synthesis or chiral pool approaches. Factories and manufacturers, particularly those in China holding GMP, ISO, SGS, TDS, and REACH certifications, often link their quality control directly to its safe distribution both in bulk and lab-scale solution. As a raw material, this compound appears in forms that include flakes, solid powder, and solution, aligning with typical packaging seen across the chemical supply chain.
Chemical manufacturers and R&D organizations lean on (S)-(+)-2-hydroxymethylpyrrolidine for its market-proven use in asymmetric catalysis, peptide synthesis, and as a crucial building block in active pharmaceutical ingredient (API) development. My colleagues in fine chemical labs often mention its use when synthesizing intermediates for antihypertensive APIs and in projects related to selective enzyme inhibition. Other uses have spread into flavor and fragrance spheres, where the chiral amine backbone influences reaction outcomes for natural analogues. The push for regulatory-compliant chemicals means buyers ask for not only MSDS, but also quality and certification reports like halal and kosher. Newcomers investigating its use often request a liter solution for initial assessment, then scale up to bulk or CIF/FOB inquiries. In the last two years, its market demand report signals a steady climb in global applications, especially among clients expecting verified compliance and tight batch-to-batch consistency.
Distributors and manufacturers handling (S)-(+)-2-hydroxymethylpyrrolidine keep hazardous goods protocols in mind. The MSDS outlines potential irritation or health risks upon contact, urging the use of PPE such as gloves and goggles. My previous experience ordering from China suppliers often required me to confirm if OEM packing or factory labeling aligns with local policy and end-user requirements—especially for international shipping under REACH, TDS, and SDS protocols. This approach ensures that every raw material supply, whether handled as powder, crystal, or solution form, carries proper hazard identification and storage advice directly to labs and production floors. Batch-specific COA, halal, kosher, and quality certifications need to be on-hand for every OEM or distributor to pass regulatory audits and meet international client standards.
Factory prices in China drive most inquiries for (S)-(+)-2-hydroxymethylpyrrolidine today. Buyers in Europe, North America, and Southeast Asia compare supply policy, sample offers, and bulk purchase MOQs before closing deals. Suppliers with GMP manufacturing status and ISO or SGS certification often win repeat business, not only for reliability but for their ability to supply with traceable documentation fast. Many customers prefer deals based on CIF ports or FOB terms, especially when projects require substantial volume. Sample requests, quotes, and OEM labeling have become standard in distributor negotiations; the more transparent the supplier with pricing, logistical details, and documentation, the better the buyer-supplier relationship survives in a market shaped by strict regulatory changes.
Anyone entering this market faces volatile raw material costs and regulatory hurdles. In recent years, the China supply channel offers stability and lower factory prices, yet market watchers notice stricter policy enforcement regarding REACH registrations and hazardous labeling. To avoid shipment holdups or import issues, businesses lean on suppliers who maintain up-to-date MSDS, REACH, and TDS files and can guarantee production through certified GMP plants. Some buyers work with multiple distributors to hedge against sudden price hikes or export bans. For those setting up new projects, ordering a free sample or requesting a liter solution for R&D testing can clarify chemical properties—stability, melting point, or solubility—prior to commitment. To match shifting demand, more suppliers streamline inquiry and quoting through instant online portals, helping ease bulk purchase and market entry for new distributors.
Through trusted supply relationships, clear safety protocols, and accurate certification, (S)-(+)-2-hydroxymethylpyrrolidine stays available for API manufacturing, R&D synthesis, and specialty chemical projects worldwide. Maintaining up-to-date MSDS, REACH, and ISO certifications supports safe and consistent access. Buyers benefit from transparent price quotes, sample policies, and distributor support from GMP or ISO-certified Chinese factories. As market demand and regulatory complexity rise, choosing experienced chemical partners equipped for compliance ensures reliable, risk-managed sourcing in today’s global supply network.
