Every chemist has a story about searching for a reliable source of high-purity intermediates. (S)-1-N-Boc-2-Cyano-Pyrrolidine frequently stands out in those stories. So much pharmaceutical innovation depends on building blocks like this. With China driving bulk production, reliable supplier networks have opened up. Chinese manufacturers now often deliver consistent GMP-grade materials at keenly competitive factory prices, whether you order as a tonne-scale distributor, a start-up researcher buying a sample, or a procurement manager chasing the best CIF or FOB rates for global delivery. You get detailed MSDS (material safety data sheet), TDS (technical data sheet), and even REACH-certified safety records, which helps ensure compliance and project continuity. The best suppliers openly offer bulk purchase solutions, free samples, MOQ negotiation, OEM services, and market reports. For many, OEM and private label opportunities enable boutique brands to tap into pharmaceutical and fine chemical supply lines, broadening access well beyond the legacy players.
This molecule tells its own story through its structure. With a pyrrolidine backbone protected by a Boc group and a cyano moiety at the two-position, it stands as a classic chiral intermediate. Molecular formula C10H16N2O2, specific density near 1.145 g/cm³, usually on offer as a brilliant white to off-white powder or crystalline solid. HS Code typically carries 2933399090, so customs paperwork gets easier. Most buyers will want to see not just COA, but ISO and SGS third-party certifications, Halal and Kosher status for global production needs, and purity specs >98% or 99% HPLC, as well as melting point (usually between 40–50°C). These concrete details mean no confusion at customs and easier validation for process chemists exploring new API syntheses, especially with bulk CIF inquiries.
Few intermediates offer lever-like importance in so many routes for pharma, biopharma, or agricultural chemistry. (S)-1-N-Boc-2-Cyano-Pyrrolidine forms a key part of structure-activity relationships in modern drug discovery, especially in research pushing for improved stereoselectivity. It’s widely used as a core fragment in the manufacture of protease inhibitors, peptidomimetic drugs, and specialty fine chemicals. One current trend is to see start-up labs ordering samples for SAR screening at sub-gram scale, scaling up fast when a lead compound hits. No-nonsense MOQ and flexible supply options matter—nobody wants to wait for a half-year contract negotiation to try a new scaffold. A European client last season spent weeks pinned down by a customs holdup due to missing HS code and density paperwork—the right supplier delivers all regulatory docs up-front, including REACH, SDS, and solution data, making these headaches disappear.
Everyone’s always tracking swings in raw material costs. Over the last three years, most chemical policy analysts have seen the market stabilize for this intermediate as more GMP-approved Chinese factories have come online. There’s real value in the quote process now—suppliers give CIF quotes, especially for European and US buyers, and will often ship sample lot as required. Price per kilogram fluctuates mainly due to cost of Boc anhydride and cyano source feedstocks, not due to scarcity of pyrrolidine. Bigger buyers like to see locked-in pricing, with OEM and halal/kosher certifications for international pharmaceutical protocols. Bulk supply support keeps research pipelines running, especially for those scaling from gram- to kilogram-scale for preclinical synthesis and commercial launch. Factory-price deals now often accompany distribution support, and wise buyers track e-ports on updated supply, regulation, and export rules—regulatory policy shifts like China’s “white list” can actually impact lead times and inventory flow.
Handling (S)-1-N-Boc-2-cyano-pyrrolidine demands respect. The MSDS lists possible skin and respiratory irritation. Most labs enforce strict PPE policy—gloves, goggles, chemical-resistant coats, and fume hoods standard issue. Many in-house protocols include secondary containment and on-site first-aid response for any hazardous chemical. The cyano group brings acute toxicity risk, so waste disposal follows hazardous material rules, never down the drain. Warehouses secure bulk drums, often in cool, dry, ventilated areas, as humidity can degrade Boc protection. ISO and SGS labels help here: third-party validation cuts corners for no one, building trust for even the most risk-averse procurement team. GMP sites log every handoff, tracking raw material to produced lot, connecting batch to batch, and provide a safety record with every shipment, meeting the expectations of regulators and downstream buyers.
There’s a reason why the market for this intermediate keeps growing. While some see it only as a “commodity”, drug discovery groups treat it as a path to unlock new molecular scaffolds, especially as regulatory agencies like the FDA and EMA keep pushing for innovative new drugs. That sparks a hunger for chiral building blocks—ones that offer specificity, stability, and compatibility with a broad menu of synthetic methods. Market demand reports show a double-digit rise in inquiries from biotech and pharmaceutical researchers, especially as more move toward green chemistry and continuous flow production. Safe, reliable, quality supply means fewer stoppages in R&D. The best suppliers stake reputations on supporting these projects, making sure purchase orders, MSDS, REACH, TDS, EOQ and application paperwork are provided the day you need them—not after another week of email ping-pong.
It’s not just about price anymore. The surge in demand for REACH, ISO, SGS, Halal, Kosher, and TDS support mirrors tougher rules in new markets. Supply chain managers want traceability—not just a “made in China” label, but audit-ready GMP tracking from raw material to finished lot, with every MSDS and COA in the cloud, accessible before an order ever leaves the port. The best distributors and manufacturers now invest in digital system upgrades, so buyers download any data sheet alongside a real-time batch spec. That level of transparency suits every regulatory regime, keeping production lines steady from Asia to Europe to North America, whether you need powder, solution, solid, or specialized flakes. Modern chemical buying means more than procurement: it brings together safety, quality, compliance, and traceability, offering options once found only at the “big six”—now spread across agile new makers in the global market.
