(S)-(+)-1-Boc-3-Hydroxypyrrolidine stands out as a key intermediate in pharmaceutical synthesis. The structure features a pyrrolidine ring protected with tert-butyloxycarbonyl (Boc), plus a hydroxyl group at the 3-position. Looking at the chemical formula, C9H17NO3, and a molecular weight close to 187.24 g/mol, manufacturers and buyers tend to focus on its granular forms—white to off-white flakes, powder, sometimes crystalline solid, depending on the synthesis batch. Factories across China, especially those following GMP practices, produce bulk quantities, shipping in 25kg drums as flakes, pearls, or powder, with specific density values around 1.1 g/cm³. Packing often comes with MSDS, TDS, and relevant certificates, ensuring safe handling and compliance.
Scouting for a chemical-buy supplier with authentic manufacturer roots in China helps maintain margins and reliability. Price remains a major factor, especially in bulk or CIF/FOB supply, but experience shows that quality and documentation play a bigger part in long-term business. Importers demand ISO 9001 and GMP records, and sometimes extra boxes checked like REACH registration, SGS, or even kosher/halal certifications based on downstream market needs. Supplier selection draws on more than catalogue prices or HS Code (2933990090); it rests on visible factory quality, consistent batch records, and proven third-party quality certification. Even with the best price, shipment without up-to-date MSDS and safety data holds little appeal. Chemical buyers, distributors, and end users request these alongside SDS and TDS for every liter or kg that leaves the factory gate.
(S)-(+)-1-Boc-3-Hydroxypyrrolidine plays its most significant role in chiral pharmaceutical intermediate production, where both structure and specific optical purity command top priority. Customers, whether in drug discovery, CROs, or large-scale pharma, look for purity figures (NMR, HPLC data), moisture results, and even colorimetry reports in quotes. This chemical’s properties—solid at room temperature, moderate solubility in water and most alcohols, not especially hazardous but needs proper labeling—impact not just the downstream chemistry but also storage and shipping choices. End users want to see stability under transport, compatibility with raw material feeds, and best-fit recommendations for synthetic routes, especially for API and specialty chemical production. Wholesalers and distributors chase bulk orders but often field single-digit or sub-kg sample requests, since R&D labs want to check compatibility before locking in large MOQ contracts.
China remains the supply hub for (S)-(+)-1-Boc-3-Hydroxypyrrolidine, with several GMP and ISO-certified manufacturers offering free samples or low MOQ for qualifying buyers. On-the-ground feedback from global importers points to factory price fluctuation tied closely with raw material volatility—especially valine, Boc anhydride, and downstream demand in custom synthesis. Freight and regulatory costs also bite into landed price. CIF and FOB quotations from Chinese suppliers compete tightly but buyers should account for real-time compliance with occupational safety and environmental policy. REACH-compliant Chinese manufacturers, for example, fetch a premium in the European market but make it simpler to clear customs and meet EU chemical regulations. Sourcing directly, skipping agents, often cuts total cost but requires vetting factory capacity, tracking quality consistency from batch to batch, and requesting extensive technical support before purchase or inquiry.
Chemical buyers—whether market veterans or newcomers—don’t just shop for a product. They check for REACH, ISO, GMP factory certifications, and want up-to-date halal, kosher, and sometimes OEM/private label options. Halal/kosher-certified shipments open new doors in Middle Eastern and Israeli markets, and buyers expect MSDS, hazard assessments, and safe handling data with every quote. A strong supplier offers transparent traceability, regular third-party audits, and often sends a sample or liter/gram quantities for local QC before finalizing a bulk contract. Wholesalers sort preferred suppliers from the rest based on how quickly and thoroughly these requests get answered. Market report analysis and policy news—especially from the European Chemicals Agency or China’s latest export guidance—can swing demand or cause buyers to pivot, pressing factories and distributors to stay ahead by adopting best safety, quality, and logistics practices.
From experience, long-term buyers of (S)-(+)-1-Boc-3-Hydroxypyrrolidine survive by establishing clear, open lines of communication with factories in China or India. It pays off to visit factories, evaluate QA/QC processes in person, and negotiate price not only in terms of raw material cost but also based on SDS, REACH, OEM, and value-added support like isotopic or D-series customization. Most importers negotiate free or low-cost samples and delivery terms (CIF, FOB) before deciding. Inquiry handling speed, understanding of HS Code requirements for customs, and the ability to provide affordable bulk pricing on repeat orders separates trustworthy chemical supply partners from the rest. Only a handful of manufacturers make every step—from sample to bulk delivery—both seamless and compliant with all mandatory quality standards. Large distributors often look for market reports and commercial updates to gauge supply risk and plan purchases, especially as new application areas or regulatory updates shift demand patterns.
