(S)-1-Boc-2-Pyrrolidinecarbonitrile carries a lot of weight for those in pharmaceutical R&D, agrochemicals, and advanced chemical synthesis. Its structure features the pyrrolidine ring fused with a nitrile group, outfitted with a tert-butoxycarbonyl (Boc) protection—a backbone hard to replace in many chiral synthesis protocols. The molecular formula comes in handy for chemists: C10H16N2O2. The HS Code used internationally for customs clearance draws a line around 2933399090, flagging this as an organic compound under specialty intermediates. Form-wise, it appears as a solid—usually powdered, sometimes arriving as crystals or flakes depending on the batch and storage condition. The material stays stable at ambient conditions with a density that hovers around 1.1 g/cm³. Water solubility runs low, but (S)-1-Boc-2-Pyrrolidinecarbonitrile dissolves in many common organic solvents, offering options for labs tuning reaction conditions or scaling for plant use.
Experience shows that the growth of the Chinese chemical industry means choices for buyers chasing quality and scale. Over fifteen years, the range of (S)-1-Boc-2-Pyrrolidinecarbonitrile manufacturers in China matured from only a handful of local enterprises to dozens delivering product with international documentation. GMP certification stands as a non-negotiable for serious pharma buyers, but ISO9001, SGS, TDS, and SDS present a full picture of quality management. OEM order support, usually with robust REACH pre-registrations and compliance, lets buyers land custom volumes to fit demand. Distributors ask about HALAL and KOSHER—these certifications are available upon inquiry, answering food and specialty sector needs. Each shipment usually includes MSDS, a certificate of analysis, and a quality statement. Buyers expect a clean document trail, and China’s bulk suppliers know it saves headaches down the road, especially when shipments pass through ports under CIF or FOB terms.
Pricing for (S)-1-Boc-2-Pyrrolidinecarbonitrile tracks the wider market for protected pyrrolidines—driven by the price of raw materials like Boc anhydride, labor, and environmental rules that rise or slacken with policy rollouts in key Chinese provinces. Factory prices, posted FOB Shanghai or CIF Rotterdam, typically beat Western counterparts. Minimum order quantity (MOQ) sits around 1 kg for small R&D work, but bulk buyers requesting 100 kg or more get lower pricing tiers. Genuine suppliers move quick on sample requests, with free samples for regular clients and stock available for spot buying. Distributors looking for market report trends find periodic updates; market demand continues strong for enantiomeric purity and trace impurity profiles, both of which impact regulatory clearance for downstream drugs. Direct-buy channels and trading platforms offer competitive quotes, but working directly with a top manufacturer streamlines negotiations, certification requests, and post-sale support—an approach learned the hard way by international buyers stung by gray-market traders.
Safety turns on good knowledge of the compound’s hazards. (S)-1-Boc-2-Pyrrolidinecarbonitrile stays classified as hazardous for skin and eye contact—so workers need gloves and eye shield at the loading dock and in the lab. The MSDS references base chemical hazards, safe storage between 2 °C and 8 °C, and transport labeling under UN number guidance. Chemical buyers push for a full SDS, not only because regulation requires it, but because experience shows that overlooked details—specific density, vapor risk, storage compatibility—matter once scaled-up or transferred between facilities. Shipments handled under IATA, IMDG, and DOT/Mexico regulations, flagged by compatible packaging, keep insurance and customs right. Several factories in China support video audits and batch-level traceability, which builds trust from overseas clients and tightens the supply loop.
Experts in contract manufacturing and custom synthesis will spot (S)-1-Boc-2-Pyrrolidinecarbonitrile’s primary use as a chiral building block. Pharmaceutical users rely on it for the synthesis of advanced intermediates, such as chiral amines, sometimes leading up to active pharmaceutical ingredient (API) targets. Recent literature in major chemistry journals highlights its role in both small-scale lab prep and industrial kilo-lab production, especially for CNS-active drugs and other fine chemicals. Global demand for this molecule trends upward, fed by rising generic drug development and newly patented small molecules. Chemical buyers, especially from European and US markets, increasingly push for documents meeting REACH, ISO, and extra specs: proof of non-animal origin, third-party impurity checks, and risk matrixes for critical control points. Feedback from power users: reliable delivery and batch consistency matter more than promotional talk; supply chain lessons learned during COVID-19 pushed many companies to dual-source—China factories stayed on-line while Western suppliers stalled.
Supply contracts now unfold with a series of inquiry, quote, and sample phases. Buyers unfazed by previous delays request pre-shipment samples for onsite QC before contract sign-off. Top Chinese suppliers keep sample stock under 500 g per batch, ready for overnight air freight up to three samples per customer. Quotes delivered by email define price per kg, lead times, QC certifications, and shipping terms—sometimes with options for increased flexibility if buyer forecasts shift or demand surges. Bulk buyers and distributors favor secure contracts with fixed price windows, direct support lines, and clear TDS, SDS, and COA delivery. Spec sheets cover melting point, solubility, physical form, and trace metals—details once overlooked but now flagged as key by pharmaceutical compliance departments. Clients purchasing for custom synthesis projects comment on the value of quick OEM modification—adjusted purity, altered particle size, and certified bulk packaging. More distributors in 2024 report interest from food sector and specialty material clients, bringing the question of HALAL, KOSHER, and other certifications into greater focus.
Markets shift, but (S)-1-Boc-2-Pyrrolidinecarbonitrile holds a firm spot due to new policies in both China and main import regions. Recent clampdowns on pollution and waste emissions have led factories near Zhejiang and Jiangsu to raise their game, offering tighter controls, electronic batch records, and waste treatment plans. China’s position as a key supplier stands reinforced by investment in GMP plants and faster customs processing for declared chemical raw materials. Industry policy now rewards exporters with a track record of environmental safety and international certification. Global buyers push for a clearer view of capacity, and direct-from-factory news helps cut rumor and uncertainty. Benchmarking against the US and European chemical supply records, China now matches or bests delivery on time, even at high-volume and short-lead production cycles.
Speaking from years buying and qualifying material from China, trust in (S)-1-Boc-2-Pyrrolidinecarbonitrile supply comes down to open communication, solid third-party certification, and a willingness to provide extras like free samples and full batch documentation. Cost savings from buying direct run high, but only work if the documents arrive with the container and the QC spec checks out in the lab. Quality means less rework, faster project turnaround, and a smoother audit when regulators or clients come calling. Bulk buyers, familiar with the learning curve, compare suppliers by their follow-through on key certifications—REACH, ISO, SGS, HALAL, KOSHER—and the technical depth in COA and SDS, not just price per kilo. Real experience—backed by a working email thread, rapid response to inquiry, and transparent quote—matters more than a flashy website or marketplace banner. Newcomers to this field can save both money and time by reading market reports, checking supply policy updates, and digging into product specifications, all of which now arrive in real-time from top-tier Chinese manufacturers.
