Anyone working in pharmaceuticals, especially with specialty intermediates, knows (R)-Boc-3-Hydroxypyrrolidine by its functional role. This molecule, C9H17NO3, with a molecular weight of 187.24 g/mol, stands out during both discovery and scale-up phases. Off-white solid or powder, density typically close to 1.1 g/cm³, forms the backbone of much peptide chemistry. China-headquartered manufacturers provide this pyrrolidine derivative in bulk or by liter solution—flaked, powdered or crystalline forms—making it practical for both small pilot runs and full commercial batches. The HS Code used for import and export remains steady: 2933399090. Out in the field, quoting CIF or FOB prices can shift with raw material volatility, yet the large China-based base keeps prices competitive, helping offset market uncertainty.
Working in a GMP-certified facility, I’ve handled substances like (R)-Boc-3-Hydroxypyrrolidine in both kilo labs and production suites. Buyers always ask for data: MSDS, COA, Reach registration, and up-to-date ISO and SGS certifications. GMP, halal, and kosher certificates, too, if the product will enter regulated drug or food chains. Hazard statements highlight respiratory and eye risks, so proper labeling and SDS (often shipped with every drum or bag) protect workers from incident. Any reputable China manufacturer or factory includes traceability: batch numbers and specifications (assay >99%, melting range around 60–62°C, water content under 0.5%). It’s easy to spot which supplier takes quality and documentation seriously—their paperwork submits early, amendments arrive on time, and they respond quickly to technical questions. In market practice, full transparency on material origin and supply chains drives international trust, especially with ongoing global supply chain concerns.
The (R)-Boc-3-Hydroxypyrrolidine structure carries a Boc-protected secondary alcohol on the pyrrolidine ring; this blocking group stays stable under ambient storage (sealed, away from moisture), enabling direct use in peptide-coupling reactions, asymmetric synthesis, and chiral pharmaceuticals. Reactivity depends on the protection/deprotection steps and the molecule’s solid state, so ease of handling ranks high for factory users. Chemists appreciate its consistency in color, flow (free-flow solids or dense crystalline powder), and easy dissolution in organic solvents. As a raw material, (R)-Boc-3-Hydroxypyrrolidine shows up in market demand reports, mainly for its use in high-value intermediates and APIs—especially newer drugs. Factory-scale production from a China supplier means MOQ is flexible; purchasing 1kg samples or tons for multistep syntheses both get swift quotes. Larger pharmaceutical companies often ask for OEM or custom synthesis, and the active China manufacturing sector adjusts plant policy to handle custom grades or ramp up at short notice.
In my work purchasing and specifying materials, inquiries often start with requests for factory price, free samples (100g to 500g is common for initial R&D), and batch production. The real story behind supply pricing involves both raw material swings and how many distributors sit between the manufacturer and end user. Direct-from-China routes, with solid logistics and customs support, save cost, especially when shipping bulk by sea or express by air for urgent timelines. Every purchase order ties to clear payment terms—30% upfront, balance against B/L—and certifications (ISO, GMP, REACH, halal, kosher) must match the client’s requirements to pass both import checks and in-house QA. Market demand, as I’ve watched across years, spikes especially after new drug filings or policy changes. New regulations drift market share toward certified, transparent suppliers in China offering direct factory pricing, especially when local resellers can't match lead time or batch traceability.
With hazardous or harmful chemical raw materials, real-world safety beats policy on paper. I always check for safe handling: store sealed under nitrogen, use gloves and goggles, and avoid sources of heat or moisture. Proper labeling, immediate MSDS access, and on-site spill protocols keep labs and plants out of trouble with regulators. Most batches, especially from top China-based manufacturers, ship in HDPE drums or double bags for solid forms; liquid and solution forms require UN-certified barrels. I’ve seen labs shift entirely to certified suppliers to meet standards like REACH and ISO. Application-wise, the product’s stable boc-protected group widens its use: small molecule innovation, peptide fragment assembly, and custom intermediates for innovator and generic drugs alike. In my own experience, switching to reliable, certified China-based supply solves both compliance and cost headaches while keeping R&D on pace.
From distributor networks to direct manufacturers, buyers want fast turnaround on quotes, stability in lead times, and practical documentation. Most suppliers respond within 24 hours with specifications, COA, and competitive pricing—even offering wholesale and bulk discount terms. Minimum order quantity (MOQ) can be as low as 100g for samples or hundreds of kilos for pilot and full-scale runs. Reliable Chinese manufacturers ship with supporting technical data, export license, safety declarations, halal/kosher or special market certifications, often beating global peers on both price and response speed. Any delays in delivery, missing certificates, or gaps in hazard disclosure break trust—repeat business goes to those who ship on time, answer technical queries, and support regulatory filings without excuse. For active buyers and R&D groups, these daily realities matter more than any sales pitch.
