(R)-3-Pyrrolidinemethanol, sometimes referenced by researchers and manufacturers under CAS 33415-64-0, stands out among pyrrolidine derivatives for its unique molecular structure and utility in pharmaceutical synthesis. With the molecular formula C5H11NO, this compound appears as a white to off-white solid powder and is often supplied as flakes, pearls, or crystalline forms, according to specific production and handling needs. The specific density commonly reported hovers around 1.03 g/cm³ at 25°C, signifying its consistency in both R&D and industrial settings. Industry catalogs in China, Europe, and North America classify (R)-3-Pyrrolidinemethanol as both a raw material and an intermediate, owing to its role in synthesizing active pharmaceutical ingredients, chiral compounds for agrochemicals, and specialty chemical materials. Structural analysis shows a pyrrolidine ring with a single hydroxymethyl substitution, giving rise to chirality and making the “R” enantiomer critical where molecular asymmetry impacts downstream activity. The HS Code often listed—2942000090—groups it under other heterocyclic compounds, which affects logistics and customs classification for bulk shipments.
Factories in China supplying (R)-3-Pyrrolidinemethanol typically provide full sets of documents such as Material Safety Data Sheets (MSDS/SDS), Certificates of Analysis (COA), TDS (Technical Data Sheet), REACH registration status, and ISO 9001, SGS, or even GMP certificates. This level of transparency spells confidence for buyers and distributors dealing in hazardous chemicals. The MSDS highlights hazards associated with solid and flake/powder forms: eye and skin irritation risk, plus mild toxicity on inhalation or ingestion—nothing out of the ordinary for organic intermediates, but responsible suppliers outline all risks, emergency procedures, and appropriate PPE standards. Many manufacturers now boast halal, kosher, or cGMP-certifications, in response to customer demand in food, pharma, and cosmetic supply chains. The use of proper packaging—fiber drums lined with plastic, sealed double PE bags, or liquid containers for solution grades—features prominently in logistics, ensuring stability during transit and storage under normal supply routes: CIF, FOB, DAP.
The production base for (R)-3-Pyrrolidinemethanol leans heavily toward Chinese cities with developed fine chemical parks and export infrastructure. These manufacturers maintain a competitive edge on factory price, able to offer low MOQs for custom synthesis or kilos-to-ton orders for bulk trade. Factory quotation requests often involve detailed batch specifications, timelines, purity requirements (often ≥99%), and end-use application disclosures, as global markets demand full traceability under tightened chemical regulations. Direct distributor partnerships cut cost points, as buying directly from manufacturer or supplying via trusted trade partners, sometimes grants free samples or technical support, all included in the initial inquiry to help buyers troubleshoot formulation or scale-up. The CIF/FOB quotes reflect global sea freight realities, though many buyers arrange spot-market pickup if located near port-based warehouses in China.
(R)-3-Pyrrolidinemethanol serves specialty segments where chirality makes a difference. Pharmaceutical developers look for this compound as a chiral building block or intermediate for complex drug molecules. Whether a company runs GMP lines or R&D scale-ups, the demand continues, underscored by generic manufacturer expansion in Asia and Latin America, where cost effect and quality compliance go hand in hand. Custom blend makers and biotech start-ups in the United States and Europe keep the market dynamic, running short and long-term trials with isomer-pure material. On the agrochemical front, new molecules for pest control often require pyrrolidine rings, boosting volume sales for fine chemical factories, especially those able to quickly adapt synthesis lines or scale according to seasonal demand. Tech application, such as specialty materials and electronics, always seek high purity and batch-to-batch consistency. The market pushes suppliers to evolve, reporting that regulatory milestones like REACH and third-party audits often decide which manufacturers make it to preferred vendor lists for global giants.
Multi-tiered end-user demands drive suppliers to adapt forms: some customers favor solid flakes or powders for integration into solid-state reactions, while others request (R)-3-Pyrrolidinemethanol in solution—usually as a liter or drum—suited for liquid-phase chemistry. The right form reduces process risk and waste, cutting cycle times in an industry where time equals profit. The liter solution finds favor for small- to mid-scale pharma labs; large chemical plants invest in ton-level drums or composite IBC containers for continuous production. Logistics and material handling teams check labels, batch numbers, and MSDS for proper storage: dry, cool, ventilated warehouses, away from direct sunlight and incompatible chemicals. Good suppliers run internal audits, making sure every shipment meets customer and Customs expectations from specific density checks to container sealing and accurate HS code labeling.
Factory price trends for (R)-3-Pyrrolidinemethanol depend on feedstock fluctuations, energy costs, and shifts in supply chain routes. COVID-19 taught procurement managers to look past the 'lowest price only' model, asking for day-to-day market price reports, supply forecasts, and commitment to on-time delivery. My own experience dealing with chemical purchases tells me that customers judge a supplier as much by the speed of response to technical questions as by the clarity of their quote: MOQ, price per kilo, bulk discounts, or OEM/private label options. The market tilts to buyers who value not just 'for sale' banners but live verification—site audits, batch sample shipment, COA, halal, kosher, and ISO certification scans sent together with trial orders. Larger buyers in pharma and biotech insist on REACH/SDS/ISO documentation before even paying a deposit; in real-world deals, both safety and compliance get checked long before the container leaves a factory in Zhejiang, Anhui, or Shandong for ports headed to Europe or North America.
Policy and compliance changes shape this market in real time. As governments debate stricter rules on hazardous and harmful chemical supply, factories adapt—switching production lines, updating safe handling practices, and running frequent employee MSDS workshops. Supply is not just about filling an order but staying ahead of new regulations on chemical raw materials, from Europe’s ECHA REACH restrictions to stricter U.S. FDA import controls. Experienced chemical buyers monitor these issues using vendor news updates, audit findings, and China supply policy announcements, since regulatory gaps can trigger delivery slowdowns or expensive compliance upgrades. A robust supplier ensures their product always comes with a full MSDS/SDS, full suite of lab reports, and application/demand/market insights so that downstream users face no setbacks from new border policies, formulation rule shifts, or unexpected market shocks.
