(R)-(-)-1-Cbz-3-Aminopyrrolidine stands out in the world of chemical intermediates, especially for pharmaceutical synthesis and fine chemical production. It carries the CAS number 117365-95-8 and falls under the molecular formula C12H16N2O2, a configuration that supports a broad spectrum of applications. Its structure features a pyrrolidine ring protected with a benzyl carbamate (Cbz) group, offering a chiral building block required for complex API development. As a solid, it can present itself as flakes or crystalline powder, generally appearing white to off-white. Typical HS Code categorization sits under 2933399090, which supports seamless export and import activities for global supply chains. Density plays a critical role in shipping and formulation parameters; (R)-(-)-1-Cbz-3-Aminopyrrolidine demonstrates specific density values around 1.18 g/cm³. Purity guidelines usually exceed 98%, confirmed by HPLC, which means technicians or procurement specialists can rely on consistencies in pre-formulation blending. Solubility profiles and melting points also offer helpful steps for material blending or safe handling. Buyers and scientists dislike surprises hidden in physical properties, so Material Safety Data Sheet (MSDS) and REACH dossiers carry detailed instructions for safe storage, transport, PPE requirements, and proper disposal steps. Hazardous classification, usually flagged on the MSDS, highlights if a compound requires extra attention due to toxicity or reactivity.
Looking at the chemical wholesale market, especially in pharma and advanced organics, most buyers look for a reliable and cost-effective link to manufacturers operating at GMP, ISO, SGS, and often halal or kosher certification standards. Right now, China’s manufacturers supply a high percentage of global (R)-(-)-1-Cbz-3-Aminopyrrolidine, offering both bulk factory-price purchase and flexible solutions like OEM, OEM-label, or customized packaging to suit regional regulations. CIF, FOB, and courier-based incoterms dominate, allowing purchasing teams to compare rates or request sample shipments before confirming a full-scale order. MOQ inquiries (minimal order quantities) are common, since pilot project validation usually comes before a long-term supply contract. From personal experience brokering raw material deals, pharma buyers prize suppliers who handle registration with REACH compliance and support documentation like TDS, SDS, COA, and third-party ISO certifications. These details smooth over most cross-border paperwork headaches.
Bulk pricing shifts quickly with international demand spikes or upstream raw material price surges, so connections to current market reports become necessary. Indonesia, South Korea, and India ramped up demand last year, and several R&D labs in Europe have asked for kilo-grade and even multi-ton shipments. This uptick led to more transparent quote responses and faster sample turnaround times from major Chinese manufacturers. In a purchasing manager’s day, that kind of speed and reliability makes a difference—every day of delay costs money. Large buyers often use distributor networks to spread risk and secure contingency supply. Free sample policies, lab-scale trial lots, and real-life application use cases (for peptide coupling, chiral auxiliary synthesis, or API intermediates) help technical teams verify the utility and trustworthiness of the source. Halal and kosher certificates also play a bigger role as more end-market pharma clients expect ethical sourcing that matches their consumer base.
(R)-(-)-1-Cbz-3-Aminopyrrolidine serves in a host of advanced syntheses, notably in targeted drugs and chiral building blocks that interface in peptide chemistry. Chemists working with this compound appreciate the predictable molecular reactivity of the protected amine, the crystalline stability, and scalable purity that factory synthesis methods—particularly in China’s FDA-inspected sites—can ensure. The market continues to grow as more pharmaceutical companies require complicated intermediates or stepwise synthesis for custom analogs. Reviewing published literature, this molecule has featured as a synthon in antihypertensive, anti-inflammatory, and antiviral research, supporting how critical high-availability and high-purity supplies are. For new chemistries, scientists sometimes request a liter solution of the compound in DMSO or ethanol, giving flexibility for automated recipes. Accurate material specification sheets support hassle-free customs clearance and minimize the risk that shipments get delayed due to mislabeling or incomplete hazard declarations. Even though many buyers focus on price, a company that delivers consistent specifications and responsive compliance data—like SDS, REACH, or quality certification forms—becomes worth the investment. Issues with hazardous labeling or transport documentation bring costly delays. With China leading supply, producers focus on safety, environmental protection compliance, and GMP traceability for each batch. Some producers offer customized solutions to meet evolving EU and U.S. regulatory frameworks as those rules grow stricter. Another trend has surfaced as innovative peptide and biopharma projects need customized packing forms: flakes, pearls, powders, or even pre-solubilized solutions. Bulk users working in closed reactors or automated setup lines want convenience and safety—less handling risk, fewer spills, and tighter weight tolerances. Specialist suppliers handle these needs by maintaining a series of certifications, from SGS to ISO 9001 and even on-demand halal or kosher paperwork, depending on the end-user’s requirements.
Many manufacturers have adopted self-auditing and third-party inspection practices, building confidence with global buyers. Experience suggests that seamless buying interactions depend on pre-negotiated sample policies, prompt sales support, and robust tracking of regulatory paperwork. Customers expect both market-competitive pricing and traceability for every lot—especially with complex intermediates like (R)-(-)-1-Cbz-3-Aminopyrrolidine. Typical buyer questions now concern impurity profiles, reproducibility run-to-run, and direct technical support. R&D customers press for specific density, melting range, and molecular formula documentation, so that switching from lab to pilot scale doesn’t create new risks or unknown variables. Market analysis shows that while demand grows for chiral intermediates, key concerns center on regulatory compliance, M&A activity among large producers, and the ability to quickly adapt supply policy to global events—like logistic bottlenecks or new GMP requirements from regulators. Manufacturers that combine real-time price updates, frequent technical literature releases, and rapid sample shipment options gain a market edge. Research teams appreciate not just the product, but a partner who shares news updates or trends about downstream API and material demand shifts. Newsletters, policy changes, and certification updates keep commercial teams ahead of the game, reducing delays or missed opportunities due to regulatory changes. Greater transparency also comes through clear application guidance. For example, TDS and technical bulletins describe how to process (R)-(-)-1-Cbz-3-Aminopyrrolidine in bulk reactors, preventive action for dust or vapors, and strategies for long-term freezer storage to avoid degradation. SGS, REACH, and ISO registration numbers matter to both procurement teams and end-user QAs, who review each batch before unlocking it for site use. In the field, safe-handling instruction often sits right on multi-language labels—data that avoids confusion on material hazards or handling in multi-user labs.
(R)-(-)-1-Cbz-3-Aminopyrrolidine will remain a mainstay for companies looking to support next-generation APIs, specialty chemical manufacturing, and expanded R&D pipelines. Forward-thinking buyers and manufacturers both watch regulatory trends and market demand closely. With China cementing its position as a supply powerhouse, international buyers prioritize certifications, technical transparency, fast response to quote and sample requests, and real-time policy updates as critical factors. Distributors expand reach, while manufacturers focus on compliance and application support. The value chain benefits from open communication, proven quality controls, and responsiveness—qualities that ultimately lead to safer, more reliable, and innovative products meeting the world’s growing pharmaceutical needs.
