Talking about (R)-1-Boc-3-hydroxylpyrrolidine, you find a product that often draws real interest from fine chemical buyers and pharmaceutical manufacturers. Structurally, it features a pyrrolidine core with a protected nitrogen through a tert-butoxycarbonyl (Boc) group and a hydroxyl at position 3. The molecular formula reads C9H17NO3, delivering a molecular weight of around 187.24 g/mol. Physical state can take the form of white to off-white powder, solid, or crystalline flakes, with a density typically listed near 1.1 g/cm³. It remains stable under recommended storage but always check the MSDS for specific handling guidance and safe-keeping temperature. The product HS Code for global trading frequently appears as 2933990099, opening up straightforward customs and logistics routing for importers and exporters.
Several qualities make (R)-1-Boc-3-hydroxylpyrrolidine a core building block in API intermediate pipelines. It dissolves well in many organic solvents, including dichloromethane, THF, and ethyl acetate, which improves compatibility for process chemists scaling up from gram to bulk liter solution stages. The raw material stands as non-volatile, but not all hazards disappear—always run a search through the safety data sheet (SDS) for REACH, GHS, or local compliance before handling. You spot no hazardous or carcinogenic rating in most country lists, but gloves, eye protection, proper ventilation, and GMP protocol remain a must. If you’re asking about certifications, many suppliers share ISO9001, SGS, Kosher, Halal, and OEM documentation on request, tightening up the confidence around product quality.
Interest keeps climbing year by year. With ever-tightening requirements for asymmetric synthesis, chiral intermediates like this one find strong use in peptidomimetic, CNS drug, and antiviral molecule development. Chemists value the Boc-protected nitrogen, which holds up under multiple synthetic steps before deprotection, and the stereospecific configuration allows easy access to single-isomer drug candidates. Large companies shine their focus on reliable, repeatable specs—so having a precise proton NMR, purity above 98%, and individual enantiomeric excess (ee) data matters to every buyer. The market for (R)-1-Boc-3-hydroxylpyrrolidine runs global, though I see most bulk shipments tracked out of China-based GMP-certified manufacturing hubs, making those factories the backbone of industrial supply.
Major chemical suppliers, notably in China, dominate the manufacture of (R)-1-Boc-3-hydroxylpyrrolidine, carrying most of the volume from city-scale facilities with GMP certification and ISO standards in production and QA. Customers usually ask for kilo to ton-scale order volumes, negotiating either CIF or FOB terms based on their internal logistics setup. The price per kilogram varies, influenced by raw material cost swings, demand from multinational API houses, and transport surcharges. If you plan to run a new project, sampling remains straightforward—reputable companies provide free sample or small MOQ (often 1-5g) for initial verification. Secure a full technical data sheet (TDS), and make sure the supplier provides an up-to-date MSDS covering storage (room temp), air/moisture sensitivity, and necessary PPE.
Importers, lab owners, pharmaceutical buyers, and distributors all put a premium on specifics: validated certificates, batch reproducibility, and secure packaging. From direct API synthesis through specialty chemical research, (R)-1-Boc-3-hydroxylpyrrolidine fills a gap where high optical purity and selective reactivity count the most. Companies purchase not only for their R&D benchwork but for ongoing pilot-to-bulk production runs, making MOQ flexibility essential for early phases. Distribution usually flows through a combination of direct supplier relationships in China and established global chemical distributors, who keep up stocks in North America, Europe, and India. Quality certifications—REACH registration, Halal, Kosher, TDS, and OEM/white-labeling—go a long way in building trust across borders, cutting down procurement risk and delivery time.
Over my years on the supplier–buyer side, supply consistency stands as one of top demands, but regulatory compliance sits right next to it. Many buyers now request annual quality audits at the factory level, alongside intermittent spot tests on incoming shipments for critical items like (R)-1-Boc-3-hydroxylpyrrolidine. With new policies for raw material controls and green chemistry incentives, manufacturers double down on sustainable production processes, entrenching their market lead. Some Chinese suppliers run in-house QC labs with full traceability for every order, linking every drum or lot with a COA. In terms of safety, the chemical, though not classed as highly hazardous, still calls for trained handling staff and robust waste disposal, since organic residues can create environmental touchpoints. MSDS and TDS documents, sometimes supplied in English and Chinese, guarantee easier onboarding for import compliance and internal EHS audits.
If you jump into the market for (R)-1-Boc-3-hydroxylpyrrolidine, most suppliers respond fast to inquiries, quote requests, and sample orders. You can reach out for pricing—usually in USD—for spot CIF, FOB, or DDP trade terms, and expect replies within at least 24 hours. After confirming specs, certificates of analysis, and pilot sample tests, buyers move forward with small lot orders or even bulk tanker dispatches depending on project stage. Some global distributors accept OEM labeling, batch-specific documentation, and handle groupage shipments for small buyers, smoothing out customs and insurance. Market reports predict steady or climbing demand moving into the next few years, especially as more new chemical entities line up in drug discovery pipelines. Monitoring import/export policies, tracking shifting price points, and gathering buyer feedback on purity and logistics reliability all play their part in making sure your procurement lines stay alive and well.
