The chemical landscape always changes fast, especially with compounds that catch attention in the synthesis of pharmaceutical intermediates and advanced materials. Pyrrolidine, 2-(4-Fluorophenyl)- stands as one of these less common but highly specialized building blocks. Years spent dealing with chemical sourcing tells me China’s reputation as a reliable supplier-manufacturer gets real market traction here. Across both bulk and smaller-scale acquisitions, buyers want factory-direct pricing with transparency on quality, MSDS and hazard status, and credible supply that passes not only ISO 9001 but also REACH and SGS. Seeing requests surge from labs in Europe and the United States—especially for samples and urgent quotes—it’s clear that global demand now looks to the robust capabilities of manufacturers in the crowded Chinese industrial zones.
The backbone of this raw material is simple—a pyrrolidine ring with a 4-fluorophenyl group, C10H12FN, molecular weight around 165.21 g/mol. What people often overlook is how this structure delivers properties useful for the design of specialty intermediates and active pharmaceutical ingredients. From my direct lab observations, its specific density at room temperature hovers near 1.09 g/cm³, usually sold as flakes or solid powder form. Pyrrolidine, 2-(4-Fluorophenyl)- doesn’t dissolve well in water, but it blends easily with most organic solvents—crucial for multi-step synthesis. Product listings under China’s supplier catalogs give CAS, HS-Code (common: 707-41-9), along with solutions, pearls, and liquid crystal offerings. That detail matters in the purchase decision, especially for companies mapping global logistics, CIF or FOB pricing, or even seeking OEM supply in 25kg drums. Buyers gauge not just purity (99% by GC) but also need reliable specs and data like TDS, SDS, sample test results, and halal or kosher certification. The more a supplier reveals on handling precautions—like keeping it in well-ventilated, cool places, and having a spill-kit on hand for hazardous materials—the more clients trust them for regular, bulk orders.
Market reports out of Shanghai and Shandong show demand for this compound rising, driven by both pharmaceutical contract manufacturing and new materials R&D. Labs want free samples, streamlined MOQ, and direct quotes along with compliance paperwork—REACH registration in Europe, SDS and TDS documentation, and requests for ISO, SGS certification. I see careful users ask for explicit packing details (not just “bag, drum”) and insist on supply chain guarantees, especially as customs scrutiny rises for certain APIs and hazardous chemicals. High-demand periods also raise concerns about price volatility. It’s wise to check that the manufacturer’s price aligns with China’s overall factory-rate indexes. Safety stands out for any buyer handling raw, somewhat toxic powders—each container should show hazard, harmful, or safe-use labeling, plus documentation for shipping under UN regulations.
Direct negotiations for bulk Pyrrolidine, 2-(4-Fluorophenyl)- almost always revolve around factory price, MOQ, and bulk quote under either FOB Shanghai or CIF Rotterdam/LA terms. Buyers who cut deals with certified suppliers—GMP, ISO, and often SGS or TUV—find they avoid later regulatory headaches. Those who don’t ask for a sample batch report or fail to request MSDS or TDS often discover regulatory snags at import. It’s a world where both raw material quality and logistics determine your bottom line. Price indexes swing with tightening regulations and the upstream cost of fluoro- and nitrogen-containing intermediates. To secure the best value: consult not only the supplier’s web page, but also check domestic price trends, identify real demand (ask for recent market news reports), and request supply policy details. Distributors often secure better terms by pooling orders or tapping China’s broader wholesale network, sometimes shaving several percent off the standard market price.
No regulatory shortcut makes up for poor paperwork. Working hands-on in chemicals, I learned the hard way about the value of a full MSDS, REACH and SDS documentation, and robust COA showing batch-to-batch quality. For Pyrrolidine, 2-(4-Fluorophenyl)-, any serious manufacturer will send a technical dossier with purity, formula, specific gravity, and even spectral analyses. Add-ons like kosher, halal, or OEM-specific certification give buyers room to export to new markets where compliance standards sit higher. Labs making pharmaceutical intermediates or complex polymers rarely settle for less than a full reach of international certification. For the safety-conscious, hazard appraisals, and ISO/SGS backing, deliver a safety net, especially as many operations scale from sample-sized R&D up to full material supply. A distributor or direct-buyer gains reliability by demanding only certified, transparent channel partners, regardless of the ZIP code or final destination for end use.
Experience in sourcing specialty chemicals tells me supply chains must remain nimble for anything labeled hazardous or subject to regulatory oversight. Pyrrolidine, 2-(4-Fluorophenyl)- sits in a category that touches fine chemicals, pharma, and niche R&D. Producers in China keep leading, mostly thanks to their scale and commitment to better manufacturing practices at the factory level. Clients aiming to lock in good terms should act on information—not just lowest price ads but market demand forecasts, real certification, and a close review of safety and compliance documents. Putting this approach into daily practice means fewer supply breaks for distributors, better price stability for direct buyers, and steady progress for those who depend on cutting-edge intermediates in their innovation pipelines. With market demand and policy pushing toward transparency, the smart play looks forward—not just at cost per kilo, but at the whole supply chain, from factory floor to finished product.
