N-T-Boc-(S)-3-Hydroxypyrrolidine, also recognized under its CAS number 143900-44-1, has gained momentum as both a crucial intermediate and a specialty raw material for pharma-grade synthesis. In the world of chemicals, sourcing matters. Pricing and supplier reliability often make or break a development timeline. Manufacturers in China churn out impressive volumes of this product with GMP and ISO certifications, giving global buyers confidence about process quality. Authentic raw material always brings a batch-specific Safety Data Sheet (MSDS/SDS) and Technical Data Sheet (TDS); working with certified suppliers—especially those offering SDS, TDS, REACH, SGS, ISO, even Halal or Kosher certifications—removes plenty of anxiety for downstream chemists and regulatory compliance managers.
Market demand for N-T-Boc-(S)-3-Hydroxypyrrolidine continues to rise, especially as synthesis needs in the pharmaceutical and fine chemical industry expand. Suppliers out of China, such as bulk manufacturers in Jiangsu or Shandong, routinely negotiate prices based on CIF, FOB, and EXW Incoterms. Minimum order quantities (MOQ) often start at one kilogram, yet scale-up orders and wholesale arrangements shift price points. International distributors recognize that buyers demand more than just a quote: they need documentation, quick sample response, and real-time inquiry channels. Free sample offers or MOQ samples allow buyers to run purity checks using certificates of analysis and confirm that material meets internal specifications before scaling up. Transparent pricing and a willingness from factories to discuss bulk or OEM custom projects gives buyers more bargaining power. Bulk volumes destined for Europe, North America, or Southeast Asia typically depend on the stability of the supply chain in China, pricing policies, and real-time demand fluctuations for chiral intermediates. One poorly-timed logistics hurdle can upend everything from factory lead times to raw material availability downstream.
Chemically, N-T-Boc-(S)-3-Hydroxypyrrolidine belongs to the family of pyrrolidines, featuring a tertiary butoxycarbonyl (Boc) protecting group and a chiral S-hydroxy functionalization at the 3-position. Structure-wise, buyers look for purity up to 99%, confirmed by H-NMR, GC-MS, and sometimes chiral HPLC analysis. Its typical formula, C9H17NO3, leads to a molecular weight close to 187.24 g/mol, usually packed as a solid or crystalline powder. Its density, specific for shipment and formulation, typically clocks in around 1.10 g/cm3. Whether as a solid, flakes, or pearls, consistent handling matters—the product stays safe under nitrogen and in cool, dry conditions. Buyers must read the MSDS closely: while not pyrophoric or shock-sensitive, this chemical counts as a hazardous substance in some jurisdictions and requires proper chemical raw material handling protocols to keep staff safe. Many manufacturers proactively provide packing in double polyethylene bags or UN-certified fiber drums, reducing the risk during transport, especially for bulk or liter-scale solution shipments.
Diving into the details, a factory or supplier selling N-T-Boc-(S)-3-Hydroxypyrrolidine in China must comply with international regulations, which sometimes means working with OEM, private-label, or distributor-buy schemes. Bulk buyers want to know they can order under specific HS-Codes—either for customs classification, R&D tax credits, or DEKRA-inspected traceability—streamlining import and export processes. Pricing evolves week by week, so industry veterans track the CIF/FOB rates and market demand reports to stay ahead of the curve. Competitive edge comes not only from the lowest price, but also from reliability: rapid quote generation, sample availability, and post-sale technical support increasingly drive market share. Manufacturers field questions about specifications—particle size, polymorph, and solubility profile—and expect to provide molecular structure images or batch-specific certificates for large-scale customers.
Sales teams focus heavily on customer access: buyers often want to place an inquiry or quote request directly through the website or distributor portal. Routine requests for TDS, MSDS, COA, and detailed photos or spectra of the actual production batch build trust. Inquiries span a full range—from sample MOQ for laboratory-scale synthesis to hundreds-of-kilo contracts for pharmaceutical suppliers. Factories that understand market needs—especially regarding new GMP plant certifications or updated REACH registrations—tend to keep strong, long-term partnerships. More factories look for OEM opportunities, allowing international brands to offer a “local” line with all the benefits of bulk China supply chains and ISO-audited safety.
Key buyers, especially those in pharmaceutical or agrochemical sectors, often ask about the application use and safety profile of N-T-Boc-(S)-3-Hydroxypyrrolidine. It's widely employed as a core building block in active pharmaceutical ingredient (API) synthesis, especially for chiral drugs, peptidomimetics, and advanced material science. Safe storage hinges on a clean, moisture-free warehouse, as the Boc group is prone to hydrolysis under acidic or wet conditions. Transport policy highlights—such as UN packing standards or mandatory SGS/ISO documentation—keep regulatory agencies satisfied and prevent shipment downtime at customs. Multinationals sometimes require certificates for Halal or Kosher standards, especially for finished dosage forms entering specialty markets in the Middle East, Southeast Asia, or Europe. Quality certification forms part of the minimum tender requirements for major brands, pushing smaller manufacturers to invest in rigorous QA and batch traceability systems.
Practical solutions for buyers focus on strong due diligence in supplier selection. Experienced procurement teams request comprehensive documentation up front: MSDS/SDS, TDS, COA, ISO certificates, and details about the manufacturing process. Even small discrepancies in molecular specification—like a minor variance in density measurements or an unlisted impurity—can derail a production run. Secure supply comes from clear, upfront communication and a willingness to pilot new batch solutions. Manufacturers and distributors that invest in supply chain transparency and customer-facing digital tools make it easier for global buyers to review literature, request instant quotes, and track shipments from factory gate to warehouse door.
