N-T-Boc-(R)-3-Hydroxypyrrolidine has become a crucial building block in pharmaceutical and fine chemical research. Anyone working in the sector has probably come across it, especially if involved with chiral intermediates or synthesis routes that demand precision and consistent molecular properties. This compound, with its CAS number and HS Code documented under official Chinese export data, stands as a reference sample for precise chemical research. Its structure—a five-membered pyrrolidine ring, featuring a tert-butoxycarbonyl (Boc) protecting group at the nitrogen and a hydroxyl group at carbon 3—lends unique reactivity and stereoselectivity in complex synthesis. The chemical formula, C9H17NO3, puts its molecular weight at about 187.24 g/mol, which might not stand out until you compare cost, shipping, and regulatory details, especially when considering CIF or FOB bulk orders from China. Physical state matters: N-T-Boc-(R)-3-Hydroxypyrrolidine usually shows up as a solid, sometimes as flakes or powder, with occasional batches in crystalline or micro-pearl forms, thanks to different Chinese factories’ process conditions. Density hovers near 1.11 g/cm³. Stability at ambient temperatures keeps the material useful for a broad window of storage and handling protocols, but thorough review of SDS and TDS files reveals that moisture, open air, and heat prompt degradation or risk for hazardous decomposition, especially during containerized shipping or liter-scale solution blending.
China has long cemented its role as the main supplier and manufacturer for this compound. The export ecosystem—composed of GMP-certified factories, ISO-audited quality inspection teams, and multiple supply lines—keeps pricing competitive, even for buyers outside the region. Sourcing agents and distributors in cities like Shanghai, Wuhan, and Hangzhou help drive down transaction friction, so international labs and commercial buyers can quote CIF, FOB, or bulk-quantity rates based on real-time market demand reports. Seasoned buyers, including myself, keep an eye on this region’s output whenever new supply policies or customs taxes shift. Prices drop the most when capacity goes up post-Chinese New Year. If product purity matters, sellers offer batch-by-batch COA, SGS, or even kosher and halal documentation. These details become decisive for pharmaceutical producers who must meet ISO standards or REACH compliance for export to the EU and the US. N-T-Boc-(R)-3-Hydroxypyrrolidine is often available with a comprehensive MSDS, REACH registration for EU, and additional quality certifications like OEM production licenses to ensure a buyer in Germany or the US isn’t left in regulatory limbo.
Safety comes first in handling this compound. Chemical buyers know the importance of an updated MSDS, especially with new REACH and GHS requirements. The substance carries some health and environmental hazards: skin and respiratory irritation risks, flammability under certain storage, and potential as a hazardous chemical raw material. To sidestep compliance headaches, reputable suppliers always include a sample SDS, TDS, and confirmation of shipment containers that meet international standards. Labs focused on API development regularly inquire about not only the product’s specific density, melting point, and molecular structure, but also transportation safety protocols—right down to UN numbers for air or sea shipping. A responsible distributor will share information about sample packages, minimum order quantities (MOQ), and whether their plant’s output is halal/kosher/SGS/ISO-certified. These factors mean that professors, startup founders, and procurement chiefs with actual experience on buying from China avoid future headaches with customs or cross-border payments.
Pharma and biotech markets drive most of the global demand for N-T-Boc-(R)-3-Hydroxypyrrolidine. Research teams crave high-purity material for synthesizing key APIs, enantiomeric drug candidates, and new molecular entities (NMEs). Investment in new capacity among Chinese GMP manufacturers keeps international supply chains resilient, even when raw material prices fluctuate. In the past year, I tracked several market demand reports: new patents for neuroactive drugs, the rise of CRO/CDMO platforms in Shanghai, and a surge in inquiry volumes before regulatory deadlines in Europe, all affecting how buyers quote MOQ, request free samples, and plan for long-term bulk purchases. Past experience reminds me that choosing a manufacturer with a transparent production process not only saves money, but also cuts down procurement cycle times and avoids the pain of substandard batches or shipping delays. Online distributor listings now often include a section for free sample applications, CIQ and customs codes, and even market insights for niche uses—such as biologic adjuvant development or research into new chiral catalysts.
Anyone facing the complex challenges in this part of the chemical industry needs more than a price comparison. Buyers working on a research grant, a startup scale-up, or contract manufacturing need to demand documentation—COA, batch HPLC, NMR spectra, and tracking of all REACH, SDS, ISO, and OEM certifications from the supplier before payment. For unknowns in pricing: always request at least three independent quotes and check seasonal supply cycles. Early sample requests from leading China suppliers build trust and let buyers test batch consistency and safety before committing to a distributor. Invest in suppliers with real market reputation, as smart social proof often beats empty claims in technical forums or anonymized PDF catalogs. Long-term, the chemical trading market for N-T-Boc-(R)-3-Hydroxypyrrolidine will keep shifting as regulations tighten, new certification standards roll out, and niche application reports surface. Smart buyers and manufacturers who keep up with these changes will stay ahead, and contribute to cleaner, safer, and more innovative products in pharmaceuticals and specialty chemicals alike.
