N-Cbz-3(R)-Hydroxypyrrolidine holds a unique structure in the organic chemistry landscape. Known for its molecular formula C12H15NO3, this compound delivers a molecular weight of 221.25 g/mol and falls within the pyrrolidine class of chemicals. The ‘Cbz’ stands for carboxybenzyl protection—widely recognized in peptide synthesis. In terms of its structure, the N-Cbz group shields the nitrogen, while the hydroxyl group rests on the third carbon of the pyrrolidine ring, which itself comprises five atoms. Most often, N-Cbz-3(R)-Hydroxypyrrolidine is found as a solid in pure form, sometimes appearing as a white crystalline powder, and its exact density depends on purity and manufacturing origin. The HS Code for this chemical varies by jurisdiction, but in China, a major exporter, customs classification helps clarify duties and reporting for global shipments. I’ve noticed manufacturers list both specific gravity and melting point on technical data sheets, reflecting the demand for detailed information about solid-state and bulk material handling, which matters in both lab and plant settings.
Over the past decade, China has asserted itself as a central hub for N-Cbz-3(R)-Hydroxypyrrolidine manufacturing. Chinese suppliers have dominated the market by offering factory-direct prices, typically ranging from small MOQ (minimum order quantity) purchases to bulk orders shipped CIF or FOB, as customers prefer. Many production lines in China operate under GMP (Good Manufacturing Practice) conditions, which assures buyers of regulated standards during synthesis, packaging, and storage. From personal experience working with international procurement teams, I’ve seen the strength of a reliable China-based partner, since they tend to provide updated COA, SDS (Safety Data Sheet), and third-party test results (SGS or ISO) without hesitation, reducing approval time for new projects. It’s not just the price point—having instant access to up-to-date MSDS and TDS means safety officers can assess hazard risks (health, environment, fire) and cleanroom managers can check for compliance with REACH, Halal, Kosher, and food or pharma certifications in one go.
Getting N-Cbz-3(R)-Hydroxypyrrolidine from the factory to a distributor or direct end-user calls for more than just competitive rates. Freight forwarders and chemical suppliers often rely on robust packaging, essential for this solid powder or crystalline compound. Double-layer bags, sealed drums, and external labeling detail all the critical handling properties. Buyers frequently request specific density, particle size, and phase information, since material handling on-site (tipping from barrel to reactor, dissolving in solvent) can become a safety or process bottleneck if not matched. Exact CAS registration—alongside up-to-date hazard statements—not only eases customs clearance but helps plant safety teams tally up hazardous raw materials for their own regulatory filings. Reporting in China often syncs with evolving policy—especially for export control—and official clearance relies as much on HS Code accuracy as on robust batch documentation. I’ve seen cases where a delay in supply chain links back to missing REACH or GHS-compliant labeling, highlighting just how critical information transfer remains in this sector.
There’s a steady global demand curve for this compound, sitting heavy in research labs as well as contract manufacturing organizations producing pharma intermediates and specialty chemicals. Market reports for the last few years pin Asia-Pacific—driven by China and India—as both the source and the biggest user of bulk material. N-Cbz-3(R)-Hydroxypyrrolidine often figures in peptide drug development, agrochemical research, and even some newer advanced material explorations. Sourcing teams have learned to leverage China-supply for more agile project schedules; direct relationships with manufacturers reduce wait times for inquiry turnarounds and sample requests. OEM options, along with custom synthesis, let end-users specify purity, functional tests, and even packaging preferences, all part of modern supplier flexibility.
End buyers trust suppliers that put quality systems front and center. In practice, this means full access to a chemical’s Certificate of Analysis (COA), confirming purity and physical characteristics batch by batch. Growing numbers of Chinese factories have won ISO 9001 and 14001 certifications, and some also certify Halal and Kosher standards for global customers spanning life sciences and food tech. OEM/ODM clients pay close attention to whether the factory upholds environmental standards—a point that matters more today, given supply chain transparency demands. Buyers need complete documentation packages: REACH certificates for Europe, FDA registration for pharmaceutical work, SGS or third-party lab test summaries for added security. Market demand, spurred on by new chemical entities and shorter development cycles, means suppliers can’t just point to price; they have to prove quality and compliance from inquiry to shipment.
Working in chemical sourcing, I’ve seen project teams run into supply problems ranging from shipping delays to shifting environmental policies. The best way forward comes from mutual transparency—sharing batch records, safety information, and clarifying product specification (form, flakes, powder, solid, pearl-grade, and even solution stock when possible). Proactive suppliers show updated policy news and material market reports, so both buyer and seller avoid nasty surprises on cost or compliance. In the long run, better supplier communication and digital traceability not only smoothen trade but also allow for safer handling and reduced operational risk. With new rules rolling out worldwide, keeping a sharp eye on SDS, hazard labeling, and real-time pricing helps buyers and manufacturers alike react fast—delivering quality, safety, and steady supply for high-value applications.
