(2R)-2-(Trifluoromethyl)Pyrrolidine always draws attention among specialty chemicals for its unique molecular structure and application potential. The compound delivers a molecular formula of C5H8F3N, placing three fluorine atoms on a pyrrolidine ring and shaping investment decisions across the global chemical market. Its specific structure boosts reactivity and introduces specialty properties, such as substantial chemical stability, resistance to harsh reaction conditions, and compatibility with custom synthesis. The molecular weight clocks in at 143.12 g/mol. As for appearance, most batches come as a clear to pale yellow liquid, carrying a relatively high specific density compared to traditional non-fluorinated pyrrolidines. This density—typically near 1.18 g/cm³ at 20°C—holds steady, supporting reliable transport and storage in bulk quantities. In terms of safety, users should consult the MSDS for data on flammability, toxicity, and environmental hazards; trifluoromethyl-containing compounds often require controlled handling, while SDS and REACH documents ensure compliance across European and Asian markets. HS Code allocation for this compound often falls under 2933399990, covering a broad range of organo-nitrogen compounds, which simplifies customs and shipping logistics for distributors in China and worldwide.
Procurement discussions for (2R)-2-(Trifluoromethyl)Pyrrolidine nearly always point to China as the dominant supply base, thanks to its established infrastructure, competitive factory pricing, and large-scale production capacity. Leading manufacturers operate GMP-certified factories and often provide ISO and SGS quality certifications, appealing to buyers requiring high assurance of consistency and compliance. It’s not uncommon to request quotes on both CIF and FOB terms, with suppliers quick to send MSDS, TDS, and test reports along with sample offers—even free in some cases for qualified bulk buyers. Many buyers chase not only the lowest price per kilogram or liter but also the shortest lead time, traceable batch records, and solid after-sale technical support. Distributors operating out of China usually offer shipment options catering to both hazardous and non-hazardous transport regulations, working with verified export policies and efficient documentation channels for international sale. Specialist suppliers frequently showcase flexible MOQs to accommodate lab-scale, pilot, or full industrial runs, enabling a smoother navigation from research chemicals to commercialized active ingredients. Applications often drive the scale: pharma intermediates, advanced agrochemical synthesis, and even liquid crystal material innovation draw on big batch supply and sampling from these top manufacturers.
Market demand for (2R)-2-(Trifluoromethyl)Pyrrolidine lies mainly in pharmaceutical synthesis and fine-chemical research. Trifluoromethyl groups serve as prized building blocks when developing new NCEs (new chemical entities), pushing medicinal chemistry efforts forward by enhancing metabolic stability, increasing bioactivity, and tuning solubility profiles. Medicinal chemists repeatedly turn to this compound in asymmetric synthesis, chiral ligand design, and active pharmaceutical intermediates. Beyond pharma, the material occasionally enters the agrochemical sector, where its unique structure enables selective herbicide and fungicide development, boosting crop protection efficiency. Liquid crystal developers have also experimented with similar pyrrolidines for phase tuning, though bulk adoption calls for enhanced cost control. Recently, application notes from top suppliers highlight additional demand from specialty polymers and electronics sectors, though most orders concentrate on pharma and fine chemical applications. Wholesale orders follow the global pulse—growing R&D in Europe and North America, solid uptake in Indian generic pharma manufacturing, and steady supply from Chinese manufacturers that balance global fluctuations in market price.
Detailing product specifications gives clarity to buyers and supports confident sourcing. Buyers receive full chemical structure diagrams along with certificates listing purity levels (often >98% by GC, HPLC), impurity profiles, melting/range, specific density, and detailed particle forms—choices between solid, flakes, powder, or concentrated solutions. These specifications help decide which supplier can meet rigorous input standards for regulated sectors. Key documentation includes not just MSDS and REACH certification, but also TDS, COA, ISO, FDA DMF filings for pharma, and kosher/halal certificates for global distribution. As global trade becomes more interconnected, buyers demand more from each batch: comprehensive lab safety sheets, shipping labels matched to dangerous goods requirements, and full traceability for raw material origins. Large distributors often publish their own market reports, analyzing pricing trends, world demand, and future policy updates. Such transparency benefits procurement managers, who can benchmark supplier performance and compare actual delivered quality—not just company promises. Increasingly, buyers compare free sample policies, OEM/private label opportunities for bulk customers, and even bespoke contract manufacturing deals targeting new API development.
Handling (2R)-2-(Trifluoromethyl)Pyrrolidine brings practical challenges—mainly ensuring consistent safety procedures across different regulatory regions, from local labeling rules to strict European REACH policy. In my own purchasing experience, partnering with suppliers who share up-to-date SDS, highlight hazardous properties, and offer technical support makes a tangible difference in plant safety and loss prevention. Investing in qualified hazardous material storage, regular team training, and ongoing compliance checks often saves time and money long term—far more than any theoretical cost reduction from cheaper, poorly documented sources. Certification systems like GMP and ISO back up supplier claims and facilitate regulatory approval on both sides of the import/export chain. The push for greener synthesis routes and safer handling procedures will soon drive innovation, as factories in China and abroad consider new solvents, recyclable packaging, and tighter digital tracking for each batch. End users can encourage progress by insisting on these improvements as part of their next purchase order, shifting market demand toward partners who treat both chemical innovation and safety as linked priorities.
