2(S)-2-Trifluoromethylpyrrolidine draws attention in pharmaceutical synthesis and specialty chemical manufacturing. This chemical, also recognized by its CAS number 1289795-17-6, features a trifluoromethyl group bound to a pyrrolidine ring, imparting unique reactivity. Its molecular formula, C5H8F3N, and structure containing a five-membered ring give it advantages in chiral compound synthesis, especially for developing intermediates in advanced drug molecules. Its HS code falls under roganic intermediates, often handled as a solid powder or flakes within dry, airtight containers. I have seen synthetic chemists demand strict molecular property data, so labs and companies rely on the MSDS (Material Safety Data Sheet) for hazardous chemical handling guidance.
2(S)-2-Trifluoromethylpyrrolidine's appearance usually ranges from off-white powder to solid pearls, depending on batch purity and manufacturing process. Its density sits near 1.32 g/cm3, and the melting point typically falls between 63-67°C. Solubility and stability data matter to customers and factory procurement teams; for instance, it holds up under common organic solvents and resists hydrolysis in neutral pH. Suppliers provide both TDS (Technical Data Sheet) and SDS/MSDS, detailing hazards such as irritant properties and requirements like gloves and goggles. Factories ensure compliance with REACH, quality (ISO 9001), SGS, HALAL, and KOSHER certifications so buyers worldwide meet local compliance. GMP (Good Manufacturing Practice) status attracts pharmaceutical buyers seeking traceability from raw material to finished product record.
My experience in international procurement steers me toward Chinese suppliers for niche organofluorine compounds. China’s chemical parks offer both bulk quantities and sample packaging, supporting everything from laboratory trials (MOQ of 1g-10g) to commercial lot scale (25kg, 200kg). Factory-direct marketing ensures that buyers obtain the best manufacturer price, with negotiation often possible on large shipments. Purchase options include CIF, FOB, and EXW, but most buyers opt for CIF, especially when supply and market trends lead to volatile raw material cost increases. I’ve seen supplier chains manage bulk shipments as well as OEM/private label production, allowing end clients to brand and distribute in local markets.
Global market demand for 2(S)-2-Trifluoromethylpyrrolidine follows innovation in active pharmaceutical ingredient (API) research and new material science. Growth in the generic drug sector multiplies requests for purity, with advanced intermediates requiring over 98% chiral selectivity. Reports from industry sources indicate price volatility based on seasonal supply and restricted export policy in some Chinese provinces. Distribution strategies include authorized agent programs and reseller incentives covering North America, Europe, South Korea, and India, which I compare before setting up long-term sourcing for project teams. Free samples and competitive quotes from reputable factories lower barriers for international buyers, letting them evaluate consistency before purchase.
Primary application comes in asymmetric synthesis of key pharmaceutical building blocks. Research teams look for low MOQ and liter-scale solutions, optimizing yield and chiral purity for custom development projects. End-users in chemical and R&D sectors demand structure confirmation, backed by NMR, HPLC, and MS data with every lot dispatched. Beyond pharma, it occasionally appears in agrochemical and advanced material development, where safety and environmental risks heighten awareness for MSDS compliance. Material managers expect distributors to provide all certification documents upfront, and to coordinate REACH/TSCA pre-registration, especially for bulk or recurring supply agreements.
B2B platforms from China collect daily inquiries on this product with buyers seeking bulk and wholesale access. I know first-hand the value of rapid response: suppliers who confirm stock, quote, and arrange same-day sample dispatch, win business over those who hesitate. Buyers want factory video, supply chain transparency, and a fast route to TDS, SDS, and spec confirmation, sometimes for custom modifications (purity adjustment, particle size, packaging). New distributors enter markets by offering custom quotes on MOQ, letting nascent research groups test material without committing to full-scale order.
Handling hazardous chemicals like 2(S)-2-Trifluoromethylpyrrolidine demands commitment to safety protocol. Chemical buyers in Europe, North America, and India focus on SDS/MSDS review before releasing purchase orders, especially when substances carry ‘harmful’ or ‘hazardous’ labels. Logistics teams work with qualified freight forwarders for DG (Dangerous Goods) shipment, using UN-approved drum and sample bottle packaging. China manufacturers update buyers on regulatory changes—it helps both sides avoid customs delay. Industry also emphasizes sustainable disposal and shelf-life adherence, shaping market practices around safety and compliance.
Choosing a reliable supply source for 2(S)-2-Trifluoromethylpyrrolidine gives buyers better control over cost, quality, and regulatory compliance. Manufacturers and distributors in China offer bulk, sample, and OEM solutions, with market-driven pricing and full document sets that meet end-user and regulatory demands. Access to quick technical support, reliable MSDS/TDS files, and flexible quote options sets leading suppliers apart in this evolving specialty chemical market.
