3-Boc-Aminopyrrolidine, sometimes listed under the HS Code 2933990099, stands out as a reliable N-protected pyrrolidine for pharmaceutical R&D and intermediate synthesis. Its chemical formula registers as C9H18N2O2 with a specific density close to 1.04 g/cm3. The structure — a pyrrolidine ring shielded with a tert-butoxycarbonyl (Boc) group — grants unique reactivity when working on peptide coupling or pipeline molecule assembly. Plenty of researchers look for this solid white powder in flakes, pearls, or refined granules. Moisture sensitivity calls for sealed containers, cool dry storage, and a careful reading of its SDS/MSDS. Multiple suppliers in China and India ship this molecule globally, offering TDS, COA, and ISO/SGS certifications to meet customer audits.
The chemical-buy landscape changed rapidly as more buyers hunt for cost efficiency without losing track of GMP production and REACH compliance. Top Chinese manufacturers control the largest facilities certified with ISO 9001, ISO 14001, and GMP. Large-scale reactors pump out metric tons of 3-Boc-Aminopyrrolidine every quarter, ensuring both affordable factory prices and continuous supply. Factory-direct sales slash distributor markups, giving buyers the most transparent CIF or FOB quotes. Customer demand still points to HACCP-certified and halal/kosher options for wider market access. For buyers, documentation remains critical — supplier reputation grows from their technical data, COA, SDS and REACH registration, all made available for easy regulatory submission in Europe or North America.
Many procurement managers used to rely on local distributors, but most now source directly from manufacturers in China for large MOQs and bulk shipments. Prices fluctuate on raw materials and logistics inputs, but direct quotes frequently undercut older channels by nearly 35%. Vendors push for full-container orders — 200kg drums or 1-ton totes — but sample packs and free trial lots help R&D labs sidestep budget hurdles. Distributors bundle 3-Boc-Aminopyrrolidine with DCM, DMF, and other synthesis materials, simplifying customs clearance and shipment tracking. Market research reports flag rising demand as pharmaceutical innovation speeds up and specialty intermediates feed new drug pipelines. Policy shifts — such as China’s strengthened chemical export controls — add volatility, so buyers lock in contracts early using formal inquiries and bulk purchase agreements.
Medicinal chemists and process engineers recognize the Boc group as indispensable for protecting amines during molecule assembly. 3-Boc-Aminopyrrolidine enables stepwise syntheses, masking nucleophilic groups until final deprotection. Proprietary route design depends on stable intermediates, so both purity and batch-to-batch consistency matter as much as cost. This material frequently appears in the supply chains for API development, custom peptides, and advanced agrochemical R&D. It fits well with other raw materials, like Fmoc-protected amino acid derivatives and macrocyclic building blocks. Experienced users study the SDS before scale-up, since dust can irritate—personal protective equipment and fume extraction prevent exposure, especially in process labs and pilot plants. Batch validation, NMR, and HPLC analyses confirm compliance to specifications every time.
Importers in the US, EU, and Southeast Asia now insist on meeting REACH, K-REACH, or Taiwan TCSCA for every bulk shipment. Sample documentation typically includes TDS, updated SDS, USP/EP/ChP test reports, ISO and GMP certificates, and audit records for traceability. More customers ask for halal and kosher certificates — not just for dietary markets, but to meet multinational audit requirements. Many factories also prep TSE/BSE and allergen statements together with origin details and HS Codes. Digital tracking from production to warehouse gives clients peace of mind, with batch numbers scannable up to shelf-life expiry. Factory visits can reveal the degree of automation, QA practices, and EHS compliance, separating experienced suppliers from unreliable traders.
Recent years turned pricing into a moving target. Increased competition among Chinese and Indian suppliers led to aggressive discounting, volume rebates, and spot-market offers, especially for long-term partners. Market intelligence firms publish monthly updates on chemical intermediate prices, tracking input costs (lithium, DMF, solvents), logistics fees, and currency swings between USD and RMB. Many large buyers split contracts across multiple suppliers to hedge risk, holding rolling RFQs on e-commerce platforms and auditing market rumors through direct WhatsApp or WeChat contacts. Supplier consolidation gave top-tier factories more leverage, but nimble buyers use smaller traders for urgent fill-in lots. For those new to advanced intermediates, upfront sample orders, third-party HPLC testing, and ISO/SGS verified audits help validate new sources.
