1-Cbz-3-Pyrrolidinecarboxylic acid appears on my desk more often than expected lately. Its use in pharmaceuticals, peptide synthesis, and fine chemicals puts this material squarely in the search history of buyers, distributors, and R&D teams across the world. With a molecular formula of C13H15NO4, HS Code 2922491990, white-flake or crystalline powder form, and true density around 1.23 g/cm³, even a glance at its technical datasheet says this molecule does serious work. Markets tracing cost trends in China see bulk kilo and ton offers quoted CIF or FOB, prices fluctuating depending on GMP-certified batches, ISO, SGS, and stricter quality certifications. Every chemist I spoke with mentions ordering detailed MSDS, TDS, and COA reports. Purity rates above 99% get praise during quality audits. Several labs in Shanghai and Shandong supply tailor-made samples as 1L or 2L solutions for rapid prototyping. Purchasing managers keep close watch on supply chain disruptions, raw material costs, and logistics policy changes as risks linger globally.
Walking the factory floor in Zhejiang, certification flags catch my eye: REACH, ISO9001, Halal, Kosher – the whole lineup. Authentic suppliers lay out a host of purchasing options: single gram samples, MOQ of 100g or 1kg, bulk orders quoted by email with up-to-date market news. Safety always stays in focus; the MSDS spells out chemical hazards, transport labeling for UN number 2811 points to potential toxicity, and storage at room temperature in sealed containers keeps quality up. Responsible manufacturers ship out each batch with an SDS, technical specification sheet, and in some cases a sample for quality testing. For distributors in Europe and North America, REACH and GMP compliance drive approval. A Chinese partner who knows international certification and documentation standards can cut weeks out of an import timeline. Chemists in purchasing prefer suppliers who disclose their synthesis process, batch testing, and impurity profile as a sign of transparency.
Every time I visit pharmaceutical development labs, teams talk up the use of 1-Cbz-3-Pyrrolidinecarboxylic Acid as an intermediate. It supports effective peptide bond protection during solid-phase synthesis, which feeds into research for anti-viral, anti-cancer, and CNS drug candidates. Some cosmetic brands in Japan and South Korea report using its derivatives for active ingredient stabilization. With the global drive for complex chiral drugs, this compound’s supply chain sits firmly on buyers’ watchlists. Trading data from 2023 shows an uptick in China-sourced raw material, thanks in part to competitive factory pricing driven by lower labor and energy costs. Some European suppliers push for “green” synthesis routes and work closely with Chinese partners to document every material input. Clients from pharma and specialty chemicals look for certificates like SGS, Halal, and Kosher due to strict end customer requirements. Inquiries for OEM and private label production grow as more buyers seek custom quantities and unique packaging for downstream manufacturing.
1-Cbz-3-Pyrrolidinecarboxylic Acid stands out with its carboxylic acid and benzyloxycarbonyl-protected pyrrolidine structure, making it valuable for peptide and small molecule API synthesis. Buyers demand detailed certificates listing physical state—flaky to solid, sometimes off-white powder—with full melting point, density, and solubility profile. This chemical’s safety profile means downstream users push for full hazard paperwork: GHS labeling, UN transport status, and specific shelf-life controls. REACH-registered batches give European buyers peace of mind, while TDS and SDS help formulators determine if it suits their needs. Flammability risks remain low, but ventilation and PPE during production line use add certainty. Environmental reporting becomes stricter year by year; buyers increasingly ask about waste solvent treatment and emissions records from Chinese suppliers. Insurance companies now mandate audit trails for every transfer, especially if products cross multiple borders under CIF or DDU terms.
A procurement manager might start with a free 10g–20g sample or liter-solution sample before any real commitment. Price negotiations span phone, email, and WeChat, with rates swung by purity certification, lead time, and shipping risk. China-based manufacturers post promotion prices for monthly contracts; some buyers in India and Europe push for wholesale deals or annual supply contracts to lock in a lower per-kilo rate. Expect to field quote requests for 5kg, 20kg, and even 200kg drum lots, with most bulk contracts shipping FOB Shanghai or Qingdao. Smaller distributors lean on local partners to provide customs documents, HS Code clarity, SGS and ISO certificates, and up-to-date market demand reports. The real action sits in the fine print: test batch acceptance, non-GMP bulk pricing, and option for free sample before the full order. Market demand fluctuates, so buyers review annual policy updates on precursor chemical controls, duty changes, and export restrictions.
Personal experience with sourcing this compound in 2023 taught me there’s no replacement for responsive supplier communication. Buyers reduce headaches by working with manufacturers who put out regular policy updates, clear quote breakdowns (CIF vs. FOB), and rapid safety data sheet uploads. Some of the most successful distributors run live compliance checks for each shipment, combining TDS, SGS testing, REACH certificates, and Halal/Kosher proof before goods leave the warehouse. A few Chinese suppliers have started offering quality guarantee periods, where unwanted or off-spec material can be returned for a partial refund or replacement. Industry insiders recommend building backup supplier relationships with at least two certified partners in case of factory shutdowns. Open, documented communication helps avoid delays from vague order terms or incomplete paperwork. Bulk buyers now ask for monthly market news and regulatory compliance summaries to keep risk down. As with most specialty materials, knowledge and careful planning at the quote and sampling stage build trust and speed up the whole process.
